Infladex

Dosage Information

Adults: Typically 20mg once daily, taken orally with or without food; swallow whole with water. For acute pain (e.g., dysmenorrhea, migraine), 40mg on day 1, then 20mg daily for up to 7-10 days. For chronic arthritis, 20mg daily long-term. Not for children. Elderly or kidney/liver patients use lowest dose (10-20mg). Monitor for side effects; consult physician if used beyond 10 days or for adjustments.

Side Effects

• Very Common (>1 in 10): Gastrointestinal disturbances (nausea, abdominal pain, indigestion).
• Common (up to 1 in 10): Skin rash/reactions, edema (swelling), malaise, brain effects (dizziness, headache), tinnitus (ringing in ears).
• Rare: Severe bleeding, allergic reactions (hives, swelling), liver enzyme elevation.

Drug Interactions

Piroxicam may interact with:

• Other NSAIDs or aspirin: Increases bleeding/ulcer risk.
• Anticoagulants (e.g., warfarin): Enhances bleeding.
• Diuretics, ACE inhibitors, ARBs: Reduces kidney function or blood pressure control.
• Lithium, methotrexate: Increases toxicity.
• Corticosteroids: Heightens gastrointestinal complications.

Indications

Approved for managing pain and inflammation in:

• Osteoarthritis.
• Rheumatoid arthritis.
• Ankylosing spondylitis.
• Dysmenorrhea (menstrual cramps).
• Toothache.
• Migraine headache.
• Post-operative pain.
• Traumatic pain.

When Not to Use

Avoid in:

• Hypersensitivity to piroxicam, aspirin, or other NSAIDs.
• Active peptic ulcers or history of recurrent ulceration.
• Severe heart, liver, or kidney failure.
• Aspirin/anti-inflammatory induced allergy.
• Third trimester pregnancy.
• Phenylketonuria (due to beta-cyclodextrin).

Precautions

• Monitor for gastrointestinal bleeding; take with food to reduce stomach irritation.
• Use cautiously in elderly, heart failure, kidney/liver impairment, or asthma patients.
• Check weight weekly; report rapid gain or swelling.
• Avoid alcohol; increases ulcer risk.
• Buy from DRAP-registered pharmacies; check holograms to avoid counterfeits.
• Limit use to shortest duration to minimize risks.

Warnings

• Gastrointestinal risk: May cause bleeding, ulcers, or perforation; stop if blood in stool or severe pain occurs.
• Cardiovascular risk: Increases heart attack or stroke chance, especially in long-term use or heart patients.
• Kidney/liver damage: Monitor function tests, especially in hot climates or fasting.
• Pregnancy: Avoid in third trimester; consult physician for earlier use.
• Overdose: Nausea, vomiting, drowsiness need urgent care.

Additional Notes

• Pregnancy Category: Consult physician; category C early, D in third trimester due to fetal risks.
• Breastfeeding: Unknown effects; avoid or consult physician.
• Availability: Common in urban and rural pharmacies; generics like Brexin available.
• Stability: Stable at room temperature; discard expired tablets.
• Reporting: Log batch for side effects; report to DRAP for quality control.

Doctor Review

Dr. Yasir Mehmood, a rheumatologist in Lahore, notes Infladex’s fast-acting relief for arthritis and menstrual pain, suitable for Pakistan’s active workforce. DRAP data supports its enhanced absorption, but Dr. Mehmood advises short-term use and gastrointestinal monitoring to avoid ulcers, especially in spicy-diet regions.

Disclaimer

This is general product information, not a prescription or medical advice. Consult your doctor or pharmacist for personal guidance.