Description
Leflunomide 10mg is a medicine used for rheumatoid arthritis. It helps by slowing down the immune system activity that causes joint pain, swelling, and stiffness. By reducing inflammation, it helps protect the joints from further damage and improves daily movement.
Ingredients
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Leflunomide 10mg
Drug Class
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Immunosuppressant
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DMARD (Disease-Modifying Antirheumatic Drug)
Dosage Form
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Tablet
Uses
Doctors may prescribe Leflunomide 10mg for:
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Reducing pain and swelling in rheumatoid arthritis
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Slowing down joint damage
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Improving movement and daily activities
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Long-term control of autoimmune arthritis
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As an option when other arthritis medicines are not suitable
How to Use
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Swallow with a glass of water
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Can be taken with or without food
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Take at the same time every day
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Always follow your doctor’s instructions
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Do not stop on your own
Dosage
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Adults: Usually started with a higher dose for a few days, then reduced to a daily dose.
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Children: Only if prescribed by a doctor.
Missed Dose
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Take as soon as you remember
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If it’s almost time for the next dose, skip the missed one
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Do not double the dose
Overdose
Too much Leflunomide can be harmful. Signs include stomach upset, severe diarrhea, or infections due to low white blood cells. Seek medical help immediately.
When Not to Use
Do not take if you:
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Are pregnant or planning pregnancy
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Are breastfeeding
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Have severe liver or kidney problems
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Have weak immunity or ongoing infections
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Have very low blood counts
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Have had severe skin reactions in the past
Side Effects
Some people may notice:
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Diarrhea, nausea, or stomach upset
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Rash or skin itching
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Hair thinning
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Headache or feeling tired
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Higher blood pressure
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Liver test changes
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More frequent infections
Precautions & Warnings
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Regular blood and liver tests are important
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Avoid alcohol, as it increases liver risk
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Not safe during pregnancy — effective birth control is required
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Stop and call your doctor if you notice rash, fever, or infection
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Monitor your blood pressure regularly
Drug Interactions
Tell your doctor if you are using:
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Methotrexate — increases risk of liver and blood problems
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Warfarin — may increase bleeding risk
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NSAIDs or certain antibiotics
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Seizure medicines like phenytoin
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Birth control pills — may be less effective
Food Interactions
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Avoid alcohol
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Avoid grapefruit juice
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Avoid very fatty meals, which may reduce absorption
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Ask your doctor before taking vitamin A or herbal supplements
Storage
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Keep at room temperature (below 25°C)
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Store in a dry place, away from heat and light
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Keep out of children’s reach
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Dispose of unused tablets safely — do not flush
Doctor’s Overview
Dr. Adeel Khan – Consultant Rheumatologist, MBBS, FCPS (Rheumatology)
Leflunomide 10 mg is a disease-modifying antirheumatic drug (DMARD) commonly used in the management of rheumatoid arthritis. It helps control long-term inflammation, relieves pain and swelling, and prevents further joint damage. Because it can affect the liver and blood counts, regular monitoring through blood tests is essential. Patients are generally advised to avoid alcohol and to use effective contraception while on this treatment.
Disclaimer
This overview is for educational purposes only. It is not a prescription. Always consult a qualified doctor or pharmacist before using Leflunomide 10 mg.

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