Neoglip

Description

Metformin 1000mg + Sitagliptin 50mg Tablet is a dual-action oral antidiabetic medication formulated to improve glycemic control in adults with type 2 diabetes mellitus. Metformin, a biguanide, works primarily by suppressing hepatic gluconeogenesis (glucose production in the liver) and enhancing insulin sensitivity in peripheral tissues such as muscles and adipose tissue. It also inhibits mitochondrial respiratory complex I, reducing ATP production and lowering glucose output.

Ingredients

Metformin 1000mg, Sitagliptin 50mg.

Drug Class

Biguanide + DPP-4 Inhibitor.

Dosage Form

Film-coated Tablet.

Uses

Metformin 1000mg + Sitagliptin 50mg Tablet is prescribed for:

• Improving glycemic control in adults with type 2 diabetes mellitus.

• Reducing hepatic glucose production and enhancing insulin sensitivity.

• Promoting glucose-dependent insulin release.

• Preventing progression from prediabetes to type 2 diabetes.

• Supporting weight management and preventing weight gain associated with diabetes.

• Lowering cardiovascular risks in diabetic patients when used long-term.

• Preventing diabetic complications when combined with diet and lifestyle modifications.

Doctor’s Review

Dr. Ayesha Karim, Consultant Endocrinologist, states:

“The combination of Metformin and Sitagliptin offers an effective and well-tolerated approach to managing type 2 diabetes. It targets insulin resistance and enhances insulin secretion without causing significant hypoglycemia. Consistency in use and dietary control are key to achieving optimal results.”

Dosage (Follow Physician’s Instructions)

• Typical Dose: Metformin 1000mg + Sitagliptin 50mg once daily.

• Swallow whole with water, preferably with food to minimize gastrointestinal discomfort.

• Your doctor may adjust the dose based on kidney function, tolerance, and glucose levels.

• Never modify or discontinue the medication without consulting your healthcare provider.

In Case of Overdose

Overdose may cause:

• Severe nausea, vomiting, abdominal pain.

• Hypoglycemia (dizziness, sweating, confusion).

• Lactic acidosis (fatigue, rapid breathing, muscle pain — seek emergency care immediately).

Treatment is supportive; gastric lavage or activated charcoal may be administered in a hospital setting.

Missed Dose

• Take as soon as remembered if within the same day.

• Skip if it’s close to the next scheduled dose.

• Do NOT double the dose

How to Use

• Swallow whole with a full glass of water.

• Take with or after meals.

• Maintain consistent daily timing for best glycemic stability.

• Do not split, crush, or chew.

When Not to Use

Avoid use if:

• Allergic to Metformin, Sitagliptin, or similar medications.

• Diagnosed with diabetic ketoacidosis.

• Suffering from severe kidney impairment or failure.

• History of pancreatitis or gallbladder disease.

• Recent heart attack or uncontrolled heart failure.

• Scheduled for surgery requiring fasting or anesthesia.

• Dehydrated or with a history of heavy alcohol intake.

Side Effects

Common:

• Nausea, diarrhea, stomach discomfort.

• Loss of appetite or metallic taste.

• Headache or fatigue.

Uncommon / Severe (Seek Medical Help):

• Skin rash, itching, or allergic swelling.

• Signs of lactic acidosis (muscle pain, breathing difficulty, chills).

Precautions & Warnings

• Use cautiously in patients with kidney or liver issues.

• Monitor glucose levels during illness, fasting, or surgery.

• Avoid alcohol consumption — increases risk of lactic acidosis.

• Report symptoms like abdominal pain or persistent nausea (may indicate pancreatitis).

• Stop medication and consult doctor if signs of lactic acidosis develop.

Drug Interactions

• Contrast agents (used in imaging scans) — may increase risk of lactic acidosis.

• Alcohol — avoid excessive intake.

• Sulfonylureas / insulin — increased risk of hypoglycemia.

• Corticosteroids, diuretics, or nephrotoxic drugs — may affect glucose or kidney function.

• CYP3A4 inhibitors — may increase Sitagliptin levels.

Food Interactions

• Limit alcohol and high-fat meals.

• Be cautious with grapefruit or grapefruit juice.

• Avoid high-sugar diets that counteract treatment.

• Follow a balanced diet rich in fiber, lean proteins, and whole grains.

• Stay well-hydrated.

Lifestyle & Diet Recommendations

• Engage in 30 minutes of daily physical activity.

• Practice carbohydrate monitoring or portion control.

• Maintain adequate hydration.

• Get regular sleep to stabilize insulin sensitivity.

• Manage stress through breathing exercises or meditation.

Storage / Disposal

• Store in a cool, dry place away from light.

• Keep tightly sealed in original container.

• Keep out of reach of children.

• Do not use past expiration date.

• Dispose via pharmacy take-back programs — do not flush or discard in trash.

Quick Tips

• Take at the same time daily

• If experiencing nausea, pair with meals.

• Never crush or split the tablet.

• Track blood glucose regularly.

• Avoid alcohol and dehydration.

Laboratory Screening

Regular monitoring may include:

Disclaimer

This information is intended for educational purposes only and does not replace professional medical advice. Use only under the supervision of a licensed physician. Do not self-medicate or adjust dosage without consultation.