Persch 4mg

Description
Persch contains Risperidone, an atypical antipsychotic medication. Its therapeutic action in schizophrenia is believed to result from combined antagonism of dopamine (D2) and serotonin (5HT2) receptors. Its clinical effects arise from both Risperidone and its active metabolite, 9-hydroxyrisperidone (Paliperidone).

Ingredients (Generic Name)
Risperidone

Drug Class
Atypical Antipsychotic (Second-Generation Antipsychotic)

Dosage Form
Oral Tablet

Requires Prescription
Yes

Uses / Indications
Indicated for the treatment of:

• Schizophrenia

Dosage
Risperidone — dose is individualized based on clinical assessment.

In Case of Overdose
May cause excessive sedation, tachycardia, low blood pressure, or extrapyramidal symptoms. Supportive medical care is required.

Missed Dose
Take as soon as remembered unless close to the next scheduled dose. Do not double dose.

How to Use
Swallow whole with water, with or without food. Follow dosage schedule as directed by a healthcare provider.

When Not to Use

• Known hypersensitivity to Risperidone, Paliperidone, or formulation excipients.

Side Effects

Serious and commonly reported effects include:

• Increased mortality in elderly patients with dementia-related psychosis.

• Cerebrovascular events (e.g., stroke) in elderly patients.

• Neuroleptic Malignant Syndrome (NMS).

• Tardive dyskinesia.

• Metabolic changes: hyperglycemia, dyslipidemia, weight gain.

• Hyperprolactinemia.

• Orthostatic hypotension and risk of falls.

• Leukopenia, neutropenia, agranulocytosis.

• Seizures.

• Dysphagia.

• Priapism.

• Temperature dysregulation.

Precautions & Warnings

• Elderly patients with dementia-related psychosis have an increased risk of death when treated with antipsychotics.

• Risk of NMS — monitor for rigidity, fever, or altered mental status.

• Tardive dyskinesia may become irreversible with prolonged use.

• Metabolic monitoring advised due to weight, glucose, and lipid alterations.

Drug Interactions

Interactions may occur with:

• Fluoxetine, Paroxetine.

• Carbamazepine.

• Ranitidine, Cimetidine.

• Erythromycin.

• Amitriptyline.

• Levodopa, Dopamine agonists.

• Ketoconazole, Verapamil.

• Furosemide.

• Paliperidone (active metabolite).

• Rifampicin.

• Anticholinergics.

Food Interactions
No major food restrictions, but consistent intake is advisable.

Storage / Disposal
Store at room temperature, away from direct heat, moisture, and light. Keep out of reach of children.

Control Drug
No

Quick Tips

• Can impair alertness — avoid high-risk activities until response is known.

• Regular monitoring of metabolic parameters is generally advised.

• Report involuntary movements or muscle stiffness immediately.

Doctor’s Note
Reviewed by Dr. Ayesha Khalid, Consultant Psychiatrist:

“Risperidone remains widely used in schizophrenia management, but long-term monitoring for metabolic and neurological effects is critical.”

Disclaimer
All information provided is for reference purposes only and should not replace professional medical guidance. Treatment decisions must be made by licensed healthcare practitioners.