Prothiaden

Dosulepin: Description, Uses, and Information for Pakistan

Dosulepin hydrochloride, the active ingredient in Prothiaden tablets, is a tricyclic antidepressant used across Pakistan. It blocks the reuptake of serotonin and norepinephrine, boosting their levels in the brain to improve mood and reduce anxiety. Its formula also interacts with muscarinic and histamine H1 receptors, providing sedative effects that help with restlessness or sleep difficulties.

Ingredients Dosulepin Hydrochloride.

Drug Class Tricyclic Antidepressant.

Dosage Form Tablet.

Uses Pakistani doctors prescribe dosulepin for:

• Moderate to severe depression.
• Anxiety disorders with ongoing worry.
• Mood disorders causing emotional swings.
• Emotional imbalance, like persistent sadness or irritability.

It’s often selected for patients needing mood stabilization and relief from sleep issues or agitation.

Doctor’s Review Dr. Rabeya Tufail, MBBS from Ziauddin University and Managing Editor at CureCartDirect, states: “Dosulepin effectively treats depression and anxiety, particularly in patients with sleep disturbances or agitation. It stabilizes mood and promotes calmness, making it suitable for chronic stress or depressive conditions when used under medical supervision.”

Dosage Dosage aligns with Pakistan Medical Association guidelines, customized by your doctor:

• Adult Dosage: Start with 75 mg daily (one 25 mg tablet three times daily or three tablets at night, two hours before bed). Maximum is 225 mg daily (nine tablets).
• Child Dosage: Not recommended.

Swallow tablets whole with water at the same time daily. If you miss a dose, take it when remembered unless it’s close to the next dose—don’t double up.

In Case of Overdose Overdose symptoms include dry mouth, drowsiness, seizures, fast heart rate, low blood pressure, or breathing problems. Seek immediate medical care in Pakistan. Treatment may include gastric lavage, activated charcoal, or ECG monitoring. Protect airways if unconscious. Bedrest is advised post-recovery.

How to Use Take tablets whole with water at a consistent time daily, as directed by your doctor.

When Not to Use Avoid dosulepin if you have:

• Hypersensitivity to dosulepin or excipients.
• Allergy to peanut or soya (contains soya lecithin).
• Recent heart attack or cardiac arrhythmias.
• Mania or severe liver disease.
• Narrow-angle glaucoma or high eye pressure.

Side Effects Possible side effects:

• Drowsiness.
• Dry mouth.
• Dizziness, especially when standing.
• Weight gain.

Contact your doctor if these persist.

Precautions & Warnings Pakistani medical guidelines advise:

• Use cautiously with bipolar disorder or psychosis—monitor closely.
• Not for severe heart conditions or those at risk for QTc prolongation.
• Monitor patients with suicidal thoughts.
• Be careful with glaucoma, urinary retention, or prostate issues.
• Taper off slowly to avoid withdrawal.
• Elderly, pregnant, or breastfeeding patients should consult their doctor.

Drug Interactions Inform your doctor about all medications. Interactions include:

• SSRIs (risk of serotonin syndrome—use cautiously).
• MAOIs like phenelzine (avoid due to hypertension risk).
• Alcohol or benzodiazepines (increase sedation).
• Anticholinergics like atropine (worsen dry mouth, constipation).
• CYP450 inhibitors like ketoconazole (raise dosulepin levels).
• CYP450 inducers like rifampin (lower dosulepin efficacy).
• Beta-blockers (enhance low blood pressure).
• Warfarin (increase bleeding risk).
• Antiepileptics like phenytoin (may reduce dosulepin levels).

Storage/Disposal Store at 15–30°C in a cool, dry place, away from heat, light, and moisture. Keep containers tightly closed, out of reach of children and pets. Avoid humid areas like bathrooms. Consult your doctor or pharmacist for disposal guidance.

Disclaimer This is product information on dosulepin, not a medical prescription. Consult a qualified Pakistani doctor for diagnosis, treatment, or dosing. Do not self-medicate based on this content.