Spasmo-Cibalgin

Introduction

This combination contains two active components — Hexahydroadiphenine and Propyphenazone. Together, they are recognized in Pakistani medical practice for short-term relief of pain, fever, and inflammation. The dual action offers stronger effectiveness than single-ingredient medicines in certain acute conditions.

How it Works

• Hexahydroadiphenine: A synthetic opioid analgesic that acts on the central nervous system by binding to mu-opioid receptors in the brain and spinal cord, reducing the perception of pain.

• Propyphenazone: A non-opioid analgesic and antipyretic. It works by inhibiting prostaglandin synthesis, which reduces pain, inflammation, and fever.

Together, they provide synergistic analgesic and antipyretic effects.

Primary Uses

In medical use across Pakistan, this combination is indicated for:

• Relief of mild to moderate pain (headache, toothache, musculoskeletal pain, post-surgical pain).

• Fever reduction in cold and flu symptoms.

• Migraine relief (short-term, symptomatic).

• Abdominal or musculoskeletal discomfort.

• Minor inflammatory pain and swelling.

Composition

• Hexahydroadiphenine.

• Propyphenazone.

• Available in tablet form.

Side Effects

Possible but not experienced by everyone:

• Drowsiness or sedation.

• Nausea, vomiting, or stomach pain.

• Constipation.

• Dizziness or lightheadedness.

• Skin rash or itching (allergic reaction).

• Difficulty in urination.

• Rare: respiratory depression, seizures (in overdose).

Warnings & Precautions

• Avoid if allergic to either ingredient.

• Use cautiously in patients with liver or kidney impairment.

• Avoid alcohol, as it increases sedation risk.

• Do not drive or operate machinery if drowsy.

• Not suitable for children under 12 years.

• Elderly patients should use with caution.

• Contraindicated in pregnancy and breastfeeding.

• Inform your doctor about all other medications to avoid interactions.

Drug Interactions

• May interact with anticoagulants (e.g., warfarin) → increased bleeding risk.

• Interaction with alcohol and CNS depressants → increased sedation.

• May reduce effectiveness of contraceptive pills.

• Can enhance the effect of antihypertensives, causing low blood pressure.

• Grapefruit juice should be avoided (alters metabolism).

When Not to Use

• Severe liver or kidney disease.

• Respiratory disorders (asthma, bronchitis).

• Gastrointestinal bleeding or obstruction.

• History of seizures or epilepsy.

• History of agranulocytosis or bone marrow depression.

• Alcohol abuse or dependency.

• Porphyria patients.

Reviewed by: Dr. Ahmed Raza, MBBS, FCPS (Internal Medicine & Pain Management)

“This combination (Hexahydroadiphenine + Propyphenazone) is sometimes used in Pakistan for short-term pain and fever relief, particularly when a stronger effect is needed. However, due to the opioid component, it must be used carefully and only under strict medical supervision. Misuse or overuse carries risks of sedation, dependence, and serious side effects.”

FAQs (Frequently Asked Questions)

Q. Can this medicine be used for migraine?
Yes, it is sometimes used for short-term migraine relief.

Q. Is it safe for children?
No, it should not be given to children under 12 years.

Q. Can I take it with alcohol?
No, alcohol increases sedative effects and risk of side effects.

Q. What happens in overdose?
Overdose may cause nausea, vomiting, dizziness, seizures, or respiratory depression. Immediate medical attention is required.

Storage & Disposal

• Store in a cool, dry place away from direct sunlight.

• Keep out of reach of children.

• Do not flush expired tablets — consult a pharmacist for safe disposal.

Disclaimer:
This content is provided for educational and informational purposes only. It is not a prescription. Always consult a licensed doctor or pharmacist in Pakistan before starting or changing any medicine.