Zaclazide

Zaclazide (Gliclazide) is an oral anti-diabetic medicine used to manage Type 2 Diabetes Mellitus (T2DM) when diet and exercise alone are insufficient. It belongs to the sulfonylurea class, which helps lower blood sugar by stimulating insulin release from the pancreas and improving the body’s response to insulin.

Key Benefits

• Controls high blood sugar in adults with Type 2 diabetes

• Helps prevent diabetic complications (neuropathy, nephropathy, retinopathy)

• Improves glycemic control and energy levels

• Reduces risk of microvascular damage

• Supports long-term HbA1c reduction when used consistently

How It Works

Gliclazide stimulates pancreatic beta cells to release insulin and enhances tissue glucose utilization. This helps maintain balanced blood sugar levels throughout the day. Regular dosing and meal timing are essential to prevent hypoglycemia.

How to Use

• Take before meals, usually once or twice daily as directed by your doctor.

• Swallow whole with water; do not crush or chew.

• Take at the same time daily to maintain stable blood sugar.

• Maintain regular meal times to avoid low sugar levels.

Doctor Review

Dr. Sameena Arif, MBBS, FCPS – Consultant Diabetologist:
“Gliclazide remains a dependable sulfonylurea for glycemic control in Pakistani T2DM patients. Its modified-release profile provides smoother insulin secretion with lower hypoglycemia risk compared to older agents like glibenclamide. Monitoring fasting glucose and HbA1c is key for dose optimization. Avoiding missed meals is crucial to prevent hypoglycemia.”

Primary Uses

• Type 2 Diabetes Mellitus (non–insulin dependent)

• Combination therapy with metformin or other oral agents for glycemic control

Side Effects

Common: Nausea, mild diarrhea, headache, dizziness, or skin rash
Less Common: Hypoglycemia (sweating, shakiness, hunger), weakness, blurred vision
Serious (rare): Liver enzyme elevation, jaundice, or allergic skin reaction

If symptoms of low blood sugar occur (sweating, confusion, tremors), take sugar or a sweet drink immediately.

Warnings & Precautions

• Pregnancy: Contraindicated; consult doctor for insulin-based alternatives.

• Lactation: Not recommended; may pass into breast milk.

• Kidney/Liver Disease: Use cautiously; dose adjustment required.

• Alcohol: Avoid—may trigger or worsen hypoglycemia.

• Driving: Avoid driving if experiencing dizziness or blurred vision.

• Infection/Surgery: May require temporary switch to insulin.

Contraindications

• Type 1 diabetes or diabetic ketoacidosis

• Severe renal or hepatic impairment

• Known hypersensitivity to sulfonylureas

• Severe infection, trauma, or surgery requiring insulin support

Drug Interactions

• NSAIDs, Beta-blockers, Thyroid meds: May alter blood sugar response

• Alcohol and antifungal drugs: Increase hypoglycemia risk

• Always inform your physician about all medications and supplements in use.

Expert Tips from CureCart Direct

• Take before breakfast for consistent action.

• Never skip meals after dosing to avoid low sugar.

• Keep glucose tablets or sweets accessible.

• Maintain routine blood glucose and HbA1c testing.

Storage

Store below 25°C, in a cool, dry place away from light and moisture. Keep out of children’s reach.

Disclaimer: This information is for educational purposes only and not a medical prescription. Use only under supervision of a qualified physician or diabetologist. CureCart Direct provides verified drug data but does not replace professional advice.