Domflash

Domperidone is a medication that helps relieve nausea, vomiting, indigestion, and bloating. It works by blocking dopamine receptors in the gut and brain, which improves stomach emptying and reduces the feeling of sickness. In Pakistan, it is widely used to support patients with digestive discomfort and nausea caused by gastrointestinal conditions or certain medications.

Primary Uses

Domperidone is commonly prescribed for:

• Relief of nausea and vomiting caused by gastrointestinal disorders or medications.

• Management of gastroparesis. (delayed stomach emptying)

• Symptomatic relief in dyspepsia. (indigestion, bloating, discomfort)

• Support in acid reflux and heartburn. by improving gastric motility

• Nausea linked to migraine attacks.

• Relief of nausea caused by Parkinson’s medications.

• Supportive treatment in chemotherapy or post-surgical nausea.

• In some cases, to enhance lactation in breastfeeding women. (off-label use under supervision)

Side Effects

Most patients tolerate Domperidone well, though some may experience:

• Headache or dizziness.

• Dry mouth.

• Abdominal cramps or diarrhea.

• Fatigue or drowsiness.

• Rash or skin reactions.

• In rare cases: irregular heartbeat. (QT prolongation)

Precautions & Warnings

• Use with caution in patients with liver or kidney problems.

• Avoid in individuals with a history of heart rhythm disorders or uncontrolled cardiac conditions.

• Do not exceed the recommended dose, as high doses may increase cardiac risk.

• Pregnant or breastfeeding women should consult a healthcare provider before use.

• Should not be used in patients with gastrointestinal bleeding, perforation, or obstruction.

• Avoid combining with medications that prolong the QT interval (such as certain antifungals or antibiotics).

Contraindications

• Severe liver impairment.

• Known hypersensitivity to Domperidone.

• Patients with a history of cardiac arrhythmias.

• Concurrent use with potent CYP3A4 inhibitors. (e.g., ketoconazole, erythromycin)

FAQs

Q: What is Domperidone mainly used for?
A: It is used to treat nausea, vomiting, indigestion, bloating, and reflux.

Q: Does it improve digestion?
A: Yes, by enhancing stomach emptying and intestinal motility.

Q: Can it be used during breastfeeding?
A: Sometimes, under medical supervision, Domperidone is used to increase milk production, but it should not be taken without a doctor’s advice.

Q: What precautions should I follow?
A: Avoid alcohol, grapefruit juice, and exceeding the prescribed dose. Report dizziness, palpitations, or fainting to your doctor immediately.

Storage & Handling

• Store at room temperature (below 30°C), away from sunlight and moisture.

• Keep out of reach of children.

• Do not use after the expiry date.

• Dispose of unused tablets responsibly; do not flush into the toilet.

Doctor’s Review
Dr. Imran Sheikh, MBBS, FCPS – Gastroenterology

“Domperidone is commonly used to relieve nausea, bloating, and discomfort caused by delayed stomach emptying. It works by improving gastric motility, which can reduce vomiting episodes and enhance digestive comfort. While it is usually well tolerated, attention is needed in individuals with heart rhythm concerns or those taking other interacting medicines. Overuse or high doses may increase the risk of side effects, so it is best suited as a short-term option under proper supervision.”

Disclaimer
This information is provided for educational and product awareness purposes only. It is not a medical prescription. Always consult a qualified physician or pharmacist before starting or adjusting any medication.