Feboric

Febuxostat 40mg Tablets Complete Product Profile

Description Febuxostat 40mg Tablets contain Febuxostat, a xanthine oxidase inhibitor used to manage chronic hyperuricemia in gout patients. It works by inhibiting the enzyme xanthine oxidase, reducing the production of uric acid, which forms painful crystals in joints, particularly in the big toe. This oral tablet effectively alleviates gout symptoms like severe pain, tenderness, and redness in adults with elevated uric acid levels, typically used when lifestyle changes alone are insufficient. It is not a painkiller but addresses the root cause of gout flares.

Ingredients Febuxostat 40mg.

Drug Class Xanthine Oxidase Inhibitor / Antigout Agent.

Dosage Form Tablet (1 pack = 20 tablets).

Uses Febuxostat 40mg Tablets are prescribed for:

• Managing chronic hyperuricemia in gout patients with symptomatic flares.
• Reducing pain, tenderness, and redness in joints caused by uric acid crystals.
• Preventing recurrent gout attacks in patients with high serum uric acid levels.
• Supporting long-term uric acid control alongside dietary modifications.
• Adjunct therapy in gout not controlled by allopurinol or other measures.

Doctor’s Review Dr. Faisal Ahmed, a leading rheumatologist in Karachi, endorses Febuxostat for its targeted uric acid reduction: “Febuxostat 40mg is highly effective for gout management, lowering uric acid levels to prevent painful flares. It’s a great option for patients intolerant to allopurinol, but regular liver and uric acid monitoring ensures safe, long-term use.”

Dosage (Follow physician’s instructions — typical guideline)

• Adults: Start with 40mg once daily, with or without food; may increase to 80mg daily after 2-4 weeks if serum uric acid remains >6mg/dL.
• Maximum: 120mg daily (rarely used); adjust in mild hepatic/renal impairment.
• Not for children or asymptomatic hyperuricemia.
• Continue even during gout flares with NSAIDs or colchicine as prescribed.
• Aim for uric acid levels <6mg/dL; monitor every 2-4 weeks initially.

In Case of Overdose Overdose may cause nausea, dizziness, or elevated liver enzymes. Seek immediate medical attention. Treatment is supportive, including monitoring liver function and vitals; no specific antidote exists. Dialysis is ineffective for Febuxostat removal. Contact a poison center if symptoms like severe fatigue or abdominal pain occur.

Missed Dose Take as soon as remembered unless close to the next dose. Do not double up to avoid side effects like liver irritation. Resume your regular schedule and consult your doctor if misses are frequent to ensure consistent uric acid control.

How to Use

• Swallow tablet whole with a glass of water, with or without food.
• Take at the same time daily (e.g., morning) for steady levels.
• Pair with a low-purine diet (e.g., avoid organ meats, shellfish) and hydration.
• Do not crush or chew tablets to maintain proper release.
• Monitor for gout flares during early treatment—use prescribed anti-inflammatories.

When Not to Use Avoid Febuxostat if:

• Allergic to Febuxostat or any excipients.
• Taking azathioprine or theophylline (serious interaction risk).
• Severe hepatic or renal impairment without dose adjustment.
• History of significant cardiovascular events (e.g., recent heart attack, stroke) unless benefits outweigh risks.
• Pregnant, breastfeeding, or planning pregnancy—consult your doctor.
• Asymptomatic hyperuricemia without gout symptoms.

Side Effects Common:

• Nausea, throat irritation.
• Joint pain (gout flares during initial treatment).
• Rash, headache, fatigue.

Uncommon / Severe (Stop and seek medical help):

• Liver dysfunction (yellowing skin, dark urine, abdominal pain).
• Allergic reactions (rash, swelling, breathing difficulty).
• Cardiovascular events (chest pain, shortness of breath).
• Severe skin reactions (blistering, peeling).

Precautions & Warnings

• Monitor liver function tests (LFTs) before and during treatment; stop if enzymes rise significantly.
• Gout flares may increase initially—use NSAIDs or colchicine as prescribed, do not stop Febuxostat.
• Use cautiously in heart disease or stroke history—higher cardiovascular risk reported.
• Check uric acid levels regularly to confirm target <6mg/dL.
• Stay hydrated (2-3L water daily) to prevent kidney stone formation.
• Avoid in severe kidney/liver disease without specialist oversight.

Drug Interactions

• Azathioprine, theophylline: Risk of severe toxicity—contraindicated.
• Mercaptopurine: Increased levels; avoid or adjust dose.
• CYP2C8 substrates (e.g., repaglinide): Potential increased levels—monitor closely.
• Warfarin: Monitor INR for bleeding risk changes.
• Diuretics: May reduce uric acid clearance—adjust as needed.
• Inform your doctor of all medications, including OTC and herbals.

Food Interactions

• Can take with or without food; no major restrictions.
• Follow a low-purine diet (avoid red meat, alcohol, sardines) to enhance efficacy.
• Limit alcohol, especially beer, to reduce uric acid production.
• Avoid grapefruit juice—may affect Febuxostat metabolism.
• Drink plenty of water (2-3L/day) to support kidney health and uric acid excretion.

Storage/Disposal

• Store at room temperature (15-30°C), in a cool, dry place away from direct light and heat.
• Keep in original packaging, out of reach of children and pets.
• Do not use past expiration date; check package for details.
• Dispose via pharmacy take-back programs; do not flush or trash to prevent misuse.

Quick Tips

• Drink 2-3L of water daily to prevent kidney stones.
• Monitor uric acid and liver function tests as advised.
• Expect initial gout flares—use prescribed pain relief, don’t stop Febuxostat.
• Avoid purine-rich foods like liver or anchovies.
• Report chest pain or severe fatigue immediately.
• Carry a medical alert card for gout and heart history.

Disclaimer This information is provided for educational purposes only and does not replace medical advice. Use only under the supervision of a licensed physician. Do not self-medicate.