Amotac 10mg

Azathioprine is an immunosuppressant used to control autoimmune diseases and prevent organ transplant rejection. It works by reducing the immune system’s overactivity, limiting inflammation, and preventing immune cells from attacking healthy tissues or transplanted organs.

Key Benefits

• Prevents organ rejection after kidney, liver, or heart transplant.

• Controls autoimmune disorders like rheumatoid arthritis and lupus.

• Helps manage inflammatory bowel disease (IBD) including Crohn’s disease and ulcerative colitis.

• Useful in autoimmune hepatitis, vasculitis, and dermatologic conditions such as eczema or psoriasis.

• Reduces immune-mediated inflammation safely under medical supervision

How It Works

After ingestion, Azathioprine converts into 6-mercaptopurine (6-MP) and further into active metabolites that suppress lymphocyte proliferation and interfere with DNA synthesis. This slows down the immune response, reducing inflammation and tissue damage in autoimmune conditions.

How to Use

• Take exactly as prescribed by your doctor—usually once or twice daily.

• Swallow whole with a full glass of water, preferably at the same time each day.

• Do not crush or chew.

• Continue therapy only under medical supervision; regular blood monitoring is essential.

Doctor Review

Dr. Huma Saleem, MBBS, FCPS – Consultant Immunologist:
“Azathioprine remains a cornerstone for autoimmune and post-transplant immunosuppression in Pakistan. Its balanced efficacy and tolerability make it suitable for long-term management when monitored properly. TPMT enzyme testing and routine blood counts are vital to minimize myelosuppression and liver toxicity risks.”

Primary Uses

• Organ transplant maintenance therapy.

• Rheumatoid arthritis, lupus, and autoimmune hepatitis.

• Crohn’s disease and ulcerative colitis.

• Vasculitis, myositis, and autoimmune dermatologic conditions.

Side Effects

Common: Nausea, fatigue, mild hair loss, diarrhea, and rash.
Less Common: Loss of appetite, fever, easy bruising, mouth sores.
Serious (rare): Liver toxicity, bone marrow suppression, increased infection risk, or skin cancer with prolonged use.

Seek immediate medical attention for persistent fever, yellowing of eyes/skin, or bleeding tendencies.

Warnings & Precautions

• Pregnancy: Avoid unless essential; may cause birth defects.

• Lactation: Not recommended—can pass into breast milk.

• Liver/Kidney Disease: Requires close monitoring; dose adjustment may be needed.

• Infections: Avoid exposure to sick individuals; drug suppresses immune response.

• Sunlight: Increases skin cancer risk—use sun protection.

• Vaccines: Avoid live vaccines during treatment.

• Blood Tests: Regular CBC and LFTs are mandatory to monitor safety.

Contraindications

• Known hypersensitivity to Azathioprine or 6-mercaptopurine.

• Severe bone marrow suppression.

• Active infections.

• TPMT enzyme deficiency.

• Severe hepatic or renal impairment (unless advised by specialist).

Drug Interactions

• Allopurinol: Increases Azathioprine toxicity—dose adjustment needed.

• ACE inhibitors / Cytotoxic drugs: Higher infection and bone marrow suppression risk.

• Live vaccines: May cause infection—avoid during treatment.

• Sulfonamides, TNF inhibitors, or antifungals: Increase adverse effects.

• Grapefruit and St. John’s Wort: Alter drug metabolism—avoid use.

Food & Lifestyle Advice

• Limit alcohol to protect liver health.

• Take on an empty stomach or with light food for better absorption.

• Maintain hydration and balanced diet.

• Avoid herbal immune boosters like black elderberry or green tea extracts.

• Use contraception during therapy and for 3 months after stopping medication.

Overdose & Missed Dose

Overdose: May cause nausea, diarrhea, and bone marrow suppression—seek immediate medical help.
Missed Dose: Take promptly when remembered; skip if near next scheduled dose. Do not double.

Storage

Store at room temperature (below 25°C), away from heat, moisture, and direct sunlight. Keep tightly sealed and out of reach of children. Dispose of unused tablets safely as per pharmacist’s guidance.

Disclaimer: This information is for educational purposes only and not a prescription. Always use Azathioprine under supervision of a qualified physician or specialist. Regular lab monitoring is essential during therapy. CureCart Direct ensures data accuracy but does not replace professional advice.