Clamoxin 625mg Tablet: Uses, Side Effects, Price, Dosage & More

When a bacterial infection strikes whether it is a nagging sinus infection, a persistent ear problem, or a urinary tract infection that just will not quit your doctor may prescribe a medicine that combines two powerful agents in one tablet. Clamoxin 625mg is exactly that. It is a widely recognized combination antibiotic available across pharmacies in India and beyond.

What Is Clamoxin 625mg?

Clamoxin 625mg is a prescription-only combination antibiotic tablet manufactured by Bliss GVS Pharma Ltd., Mumbai, India. Each tablet contains:

• Amoxycillin — 500mg
• Clavulanic Acid (Potassium Clavulanate) — 125mg

Together, these two compounds form what is medically known as Co-Amoxiclav the same combination sold globally under names like Augmentin and Clavulin. This medicine is available only with a valid doctor’s prescription and should never be used for self-medication.

How Does Clamoxin 625mg Work?

Each ingredient in Clamoxin plays a separate but teamwork-dependent role.

Amoxycillin — The Antibiotic

Amoxicillin is a broad-spectrum beta-lactam antibiotic. It kills bacteria by attacking their cell wall. Bacteria depend on a layer called peptidoglycan to keep their cell wall intact. Amoxicillin binds to penicillin-binding proteins (PBPs) the enzymes that build this layer and shuts them down. Without a functional cell wall, the bacteria collapse and die, a process called lysis. (StatPearls — Amoxicillin, NCBI Bookshelf)

The Resistance Problem:

Many bacteria have evolved a clever defense: they produce enzymes called beta-lactamases that chemically break apart amoxicillin before it can work. Once destroyed, the antibiotic becomes useless. This is one of the most common drivers of antibiotic resistance worldwide. (StatPearls Amoxicillin Clavulanate, NCBI Bookshelf)

Clavulanic Acid — The Shield:

Clavulanic acid is a beta-lactamase inhibitor. On its own it has virtually no antibacterial effect, but it permanently disables beta-lactamase enzymes by locking onto their active site a process scientists call “suicide inhibition.” With those enzymes neutralized, amoxicillin can do its job freely. (StatPearls Clavulanic Acid, NCBI Bookshelf; Wikipedia Clavulanic Acid)

The bottom line: amoxicillin kills the bacteria, and clavulanic acid makes sure the bacteria cannot fight back.

What Is Clamoxin 625mg Used For?

Clamoxin is indicated for bacterial infections caused by beta-lactamase-producing organisms across multiple parts of the body.

Respiratory Tract Infections:

This covers community-acquired pneumonia (CAP), acute bronchitis, and lower respiratory tract infections. The Infectious Diseases Society of America (IDSA) and the American Academy of Otolaryngology’s Head and Neck Surgery guidelines both recommend amoxicillin-clavulanate over amoxicillin alone for acute bacterial rhinosinusitis. (StatPearls — Amoxicillin Clavulanate, NCBI Bookshelf)

Ear Infections (Otitis Media):

Acute middle ear infections caused by bacteria are a primary indication for Clamoxin.

Sinus Infections (Sinusitis):

Bacterial sinusitis where the sinus cavities become infected and inflamed responds well to this combination.

Urinary Tract Infections (UTIs):

Clamoxin is prescribed for UTIs caused by beta-lactamase-producing strains of Escherichia coli, Klebsiella species, and Enterobacter species. (DailyMed — FDA Prescribing Information, U.S. National Library of Medicine)

Skin and Soft Tissue Infections:

This includes boils, abscesses, cellulitis, bite wounds, and surgical wound infections caused by resistant strains of Staphylococcus aureus and related organisms.

Dental and Oral Infections:

Tooth abscesses and other oral cavity bacterial infections are commonly treated with Co-Amoxiclav.

Bone and Joint Infections:

Bacterial osteomyelitis and joint infections may be treated with Clamoxin as part of a broader management plan.

Tonsillitis:

Bacterial tonsillitis caused by susceptible organisms also falls within the indications. (1mg.com Clamoxin 625 Tablet)

One thing worth repeating clearly: Clamoxin has zero effect on viral infections the common cold, flu, and COVID-19 will not respond to it. Using antibiotics for viral illnesses only contributes to the growing global problem of antibiotic resistance. (Mayo Clinic Amoxicillin and Clavulanate)

Dosage and How to Take Clamoxin 625mg

Always follow your doctor’s instructions. The guidance below is based on standard prescribing information and is not a substitute for a doctor’s advice.

Standard Adult Dose:

One tablet (500mg/125mg) every 8 hours, or one tablet every 12 hours for moderate infections. For severe infections, especially of the respiratory tract, the dose may be adjusted upward by your doctor. (Drugs.com Amoxicillin/Clavulanate Dosage Guide)

How Long to Take It:

A standard course runs 5 to 14 days. The UK Committee on Safety of Medicines recommends that treatment with amoxicillin/clavulanic acid should not normally exceed 14 days. (Wikipedia — Clavulanic Acid)

How to Take It Correctly:

• Swallow the tablet whole with a full glass of water do not crush, chew, or break it
• Always take it at the start of a meal: this improves clavulanic acid absorption and reduces stomach discomfort (DailyMed; Drugs.com — Patient Tips)
• Space doses evenly throughout the day to keep steady drug levels in your blood
• Take it at the same time each day so you do not forget a dose

Missed Dose:

Take it as soon as you remember. If your next dose is due soon, skip the missed one. Never double up. (MedlinePlus — Amoxicillin and Clavulanic Acid)

Complete the Full Course:

This cannot be stressed enough. Feeling better in two or three days does not mean the infection is fully cleared. Stopping early gives surviving bacteria a chance to come back — and next time they may be resistant. (1mg.com Clamoxin 625 Tablet)

Side Effects of Clamoxin 625mg

Not everyone experiences side effects, and many are mild and temporary. Here is what to know.

Common Side Effects

These usually improve as your body adjusts:

• Nausea
• Vomiting
• Diarrhea
• Mucocutaneous candidiasis (fungal overgrowth in the mouth or genitals, because the antibiotic also disrupts beneficial bacteria)
• Skin redness or mild rash

(1mg.com — Clamoxin 625 Tablet; Apollo Pharmacy — Clamoxin 625 Tablet)

Serious Side Effects — Stop the Medicine and Seek Immediate Help

• Severe allergic reaction (anaphylaxis): Hives, swelling of the face or throat, difficulty breathing, or sudden drop in blood pressure. At the first sign of a skin rash or hypersensitivity, stop the medication immediately. Severe cases may require epinephrine. (Drugs.com — Dosage Guide)
• Liver problems: The clavulanic acid component has been associated with cholestatic jaundice and acute hepatitis during or shortly after treatment. Warning signs include yellowing of the skin or eyes, dark urine, upper right abdominal pain, and unusual fatigue. Elderly patients on prolonged courses face a higher risk. (Wikipedia — Clavulanic Acid; Apollo Pharmacy)
• C. difficile-associated diarrhea: Bloody or persistent watery diarrhea — even weeks after finishing the course — can signal a Clostridium difficile infection, a serious gut complication possible with almost any antibiotic. (Drugs.com — Patient Tips)
• Dizziness and fits (convulsions): These can occur, especially with high doses or kidney impairment, and can affect your ability to drive or operate machinery safely. (PharmEasy — Clamoxin 625mg; 1mg.com)
• Tooth discoloration in children: Brown, yellow, or gray staining may occur in pediatric patients. Professional dental cleaning can reduce or eliminate this. (Drugs.com — Patient Tips)

Drug Interactions

Always give your doctor a complete list of every medicine, supplement, or herbal product you are taking before starting Clamoxin.

Notable interactions:

• Warfarin / anticoagulants: Increased bleeding risk. Regular PT-INR monitoring is advised. (PharmEasy — Clamoxin 625mg)
• Methotrexate: Clamoxin can reduce methotrexate clearance by the kidneys, increasing its toxicity. Watch for unusual tiredness, bruising, or fever. (Apollo Pharmacy — Clamoxin 625 Tablet)
• Allopurinol: Combined use raises the risk of skin rash significantly.
• Probenecid: May raise blood levels of amoxicillin by slowing its elimination.
• Oral contraceptives: The combination can reduce the effectiveness of hormonal birth control. Use an additional contraceptive method during the course. (MedlinePlus — Amoxicillin and Clavulanic Acid)
• Mycophenolate mofetil: Used in organ transplant patients — use with caution.
• Live bacterial vaccines (BCG, cholera): Antibiotics may reduce vaccine effectiveness. Inform your doctor if you have received or are about to receive a live bacterial vaccine within 14 days. (Apollo Pharmacy — Clamoxin 625 Tablet)
• Doxycycline: May reduce Clamoxin’s therapeutic effect when taken simultaneously.

Who Should NOT Take Clamoxin 625mg?

Clamoxin is contraindicated if you:

• Are allergic to amoxicillin, clavulanic acid, penicillin, or any beta-lactam or cephalosporin antibiotic
• Have previously developed liver problems or jaundice while on a penicillin or cephalosporin
• Have been diagnosed with hepatitis
• Have a history of severe allergic reactions to any antibiotic

(PharmEasy — Clamoxin 625mg; 1mg.com — Clamoxin 625 Tablet)

Use with caution in:

• Kidney disease: Dose adjustments are required. The drug is not recommended in severe kidney disease, and patients with creatinine clearance below 30 mL/min should not use the 875mg tablet. (Drugs.com — Dosage Guide)
• Liver disease: Liver function should be monitored regularly throughout treatment. (Drugs.com — Dosage Guide)
• Elderly patients: Prolonged use in older adults has been associated with an increased risk of jaundice. (Apollo Pharmacy — Clamoxin 625 Tablet)

Pregnancy and Breastfeeding

Pregnancy

The safety of Clamoxin in pregnancy has not been firmly established in human studies. Your doctor will weigh the benefits against potential risks. Do not take this medicine during pregnancy unless your doctor has specifically directed you to do so. (1mg.com — Clamoxin 625 Tablet)

Breastfeeding

The drug passes into breast milk and can cause oral thrush and diarrhea in nursing infants. It is advised to avoid breastfeeding during treatment or to hold breastfeeding until the course is completed and the drug has cleared your system. (PharmEasy — Clamoxin 625mg Tablet)

Alcohol and Driving

Alcohol: Avoid alcohol during the course of treatment. It can worsen side effects such as dizziness and increase the risk of fits. (PharmEasy — Clamoxin 625mg Tablet)

Driving: Clamoxin can cause dizziness, allergic reactions, and in rare cases fits — all of which impair your ability to drive or operate machinery. Until you know how this medicine affects you, avoid driving or tasks that require full mental alertness. (PharmEasy — Clamoxin 625mg; 1mg.com — Clamoxin 625 Tablet)

Overdose

Do not exceed the prescribed dose. Taking too much increases the risk of stomach upset and convulsions. If an overdose is suspected, seek emergency medical care immediately. (Apollo Pharmacy — Clamoxin 625 Tablet)

Lab Tests to Monitor During Treatment

Your doctor may recommend certain tests during or after a course of Clamoxin, particularly for prolonged treatment or in patients with existing health conditions:

• Complete Blood Count (CBC): Monitors red cells, white cells, and platelets — useful for detecting signs of infection progression or drug-related blood changes
• Liver Function Tests (LFTs): Important given this combination’s known association with liver effects
• PT-INR: Essential for patients on warfarin or other blood thinners

(MediBuddy — Clamoxin 625 Tablet; Drugs.com — Dosage Guide)

Price of Clamoxin 625mg

Clamoxin 625mg is manufactured by Bliss GVS Pharma Ltd. and is available in strip packs.

• Strip of 6 tablets: MRP approximately ₹99, available at around ₹69–₹70 with online discounts (PharmEasy — Clamoxin 625mg Tablet)
• Strip of 10 tablets: MRP ₹190 (Apollo Pharmacy — Clamoxin 625 Tablet)

Prices vary by retailer, city, and applicable taxes. Always buy from a licensed pharmacy with a valid prescription.

Generic Substitutes for Clamoxin 625mg

Clamoxin is a branded form of Co-Amoxiclav (Amoxycillin 500mg + Clavulanic Acid 125mg). Several other brands in India contain the identical active ingredients and dosage, including Augmentin 625, Amoxyclav 625, and Mox CV 625, among others. If your doctor or pharmacist suggests switching to a generic or alternative brand, this is medically acceptable provided the salt composition matches exactly. Always confirm the switch with your prescribing doctor before making any change.

Storage Instructions

• Store in a cool, dry place at 10°C to 25°C (or below 30°C), away from direct sunlight and moisture
• Keep out of the reach of children
• Do not use after the expiry date on the pack
• Do not flush unused medicine — ask your pharmacist about proper safe disposal

(Apollo Pharmacy — Clamoxin 625 Tablet)

This blog post is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional before starting, stopping, or changing any medication.

References

• Mayo Clinic — Amoxicillin and Clavulanate (Oral Route): https://www.mayoclinic.org/drugs-supplements/amoxicillin-and-clavulanate-oral-route/description/drg-20072709
• MedlinePlus (U.S. National Library of Medicine) — Amoxicillin and Clavulanic Acid: https://medlineplus.gov/druginfo/meds/a685024.html
• DailyMed (U.S. National Library of Medicine) — Amoxicillin and Clavulanate Potassium Tablets, FDA Prescribing Information: https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=89092bb8-6a1c-e23e-e053-2a95a90aa750
• Drugs.com — Amoxicillin/Clavulanate Dosage Guide: https://www.drugs.com/dosage/amoxicillin-clavulanate.html
• Drugs.com — Amoxicillin/Clavulanate Patient Tips: https://www.drugs.com/tips/amoxicillin-clavulanate-patient-tips
• StatPearls, NCBI Bookshelf — Amoxicillin Clavulanate: https://www.ncbi.nlm.nih.gov/books/NBK538164/
• StatPearls, NCBI Bookshelf — Clavulanic Acid: https://www.ncbi.nlm.nih.gov/books/NBK545273/
• StatPearls, NCBI Bookshelf — Amoxicillin: https://www.ncbi.nlm.nih.gov/books/NBK482250/
• Wikipedia — Clavulanic Acid: https://en.wikipedia.org/wiki/Clavulanic_acid
• PharmEasy — Clamoxin 625mg Tablet: https://pharmeasy.in/online-medicine-order/clamoxin-625mg-tablet-108087
• 1mg.com — Clamoxin 625 Tablet: https://www.1mg.com/drugs/clamoxin-625-tablet-758969
• Apollo Pharmacy — Clamoxin 625 Tablet: https://www.apollopharmacy.in/medicine/clamoxin-625-tablet-10-s
• MediBuddy — Clamoxin 625 Tablet: https://www.medibuddy.in/order-medicines/clamoxin-625-tablet-1000426147
• Meldinpharma — Clamoxin 625mg Tab: https://www.meldinpharma.com/shop/gvs-06-clamoxin-625mg-tab-amoksiklav-2785