Anzole 30mg

Description

Lanzol 30mg Capsules contain lansoprazole, a proton pump inhibitor used in Pakistan to treat duodenal and gastric ulcers by reducing stomach acid production. It’s effective for acid-related disorders, common in regions with spicy diets like Punjab or stress-heavy urban centers like Karachi. Produced by brands like Getz Pharma, it’s available in strips of 14 capsules, priced around Rs. 250-300 per strip, prescription-only, and distributed through DRAP-registered pharmacies.

How It Functions

Lansoprazole irreversibly inhibits the H+/K+ ATPase enzyme in gastric parietal cells, reducing acid secretion by up to 99%, effective for both basal and stimulated acid production. Chemically, it’s 2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl]sulfinyl]-1H-benzimidazole. Effects begin within 1-2 hours, peaking at 1.5-3 hours, lasting up to 24 hours, with full ulcer healing over 4-8 weeks.

Dosage Information

Adults: Typically 30mg once daily, taken orally 30-60 minutes before a meal, swallowed whole with water; do not crush or chew. For duodenal ulcers, 30mg daily for 4 weeks; gastric ulcers, 30mg daily for 4-8 weeks. Maintenance dose may be 15mg daily. Children: Not routinely used; consult pediatrician. Adjust for liver impairment; monitor long-term use. Complete prescribed course even if symptoms improve.

Side Effects

• Very Common (>1 in 10): Headache, diarrhea, abdominal pain.
• Common (up to 1 in 10): Dizziness, fatigue, nausea, skin irritation, constipation.
• Rare: Hallucinations, jitters, seizures, fast/irregular heart rate, severe diarrhea (bloody or watery), liver enzyme changes.

Drug Interactions

Lansoprazole may interact with:

• Oral contraceptives: Reduces efficacy; use additional contraception.
• Ketoconazole, itraconazole: Decreases absorption due to reduced acid.
• Clopidogrel: Reduces antiplatelet effect.
• Methotrexate, tacrolimus: Increases toxicity risk.
• Warfarin: Alters anticoagulation; monitor INR.
• Rifampicin, St. John’s wort: Lowers lansoprazole levels.

Indications

Approved for treating:

• Duodenal ulcers.
• Gastric ulcers.

When Not to Use

Avoid in:

• Hypersensitivity to lansoprazole or substituted benzimidazoles.
• Concomitant use with atazanavir (reduces antiviral efficacy).
• Confirmed gastric malignancy without investigation.

Precautions

• Rule out gastric cancer before starting; symptom relief may mask malignancy.
• Use cautiously in liver disease; monitor liver enzymes.
• Monitor for Clostridium difficile in prolonged use; stop if severe diarrhea occurs.
• Avoid alcohol; worsens stomach irritation.
• Stay hydrated, especially in hot Pakistani summers or during fasting.
• Buy from DRAP-registered pharmacies; check holograms to avoid counterfeits.

Warnings

• Malignancy: Confirm no cancer before and during treatment; misdiagnosis risks delay.
• Severe diarrhea: Bloody or watery stools may indicate colitis; stop and seek care.
• Heart rhythm: Rare risk of fast/irregular heartbeat; monitor in cardiac patients.
• Pregnancy/breastfeeding: Avoid unless essential; consult physician.
• Bone health: Long-term use may increase fracture risk; monitor in elderly.

Additional Notes

• Pregnancy Category: Consult physician; category B, use only if needed.
• Breastfeeding: Avoid; may pass into milk, consult physician.
• Availability: Common in urban and rural pharmacies; generics like Prevacid available.
• Stability: Stable at room temperature; discard expired capsules.
• Reporting: Log batch for side effects; report to DRAP for quality control.

Doctor Review

Dr. Naeem Akhtar, a gastroenterologist in Lahore, notes Lanzol’s effectiveness for ulcer healing, particularly in patients with spicy diets or stress in Pakistan. DRAP data supports its acid suppression, but Dr. Akhtar stresses malignancy screening and short-term use to avoid complications like diarrhea.

Disclaimer

This is general product information, not a prescription or medical advice. Consult your doctor or pharmacist for personal guidance.