Hydroxyzine
is an antihistamine used to treat severe allergies such as pruritus and chronic urticaria. as well as works well to treat anxiety and tension associated with psychoneuroses.
The H
1
histamine receptor is responsible for hypersensitivity and allergic reactions. Hydroxyzine is a inverse agonist of histamine H
1
-receptors. Hydroxyzine is not a cortical depressant, its sedative properties are at subcortical level of CNS, due to these properties it has anxiolytic effects as well.
CONTRAINDICATIONS:
Its use is contraindicated in patients with chronic liver disease, heart rhythm issues, and asthma patients with a history of previous serious antihistamine-induced adverse effects on the lungs.
SIDE-EFFECTS:
Side-effects include drowsiness, headache, dry mouth, fatigue and disturbance in heart rhythm.
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