Avanep

Avanep (Nepafenac 0.1%) is an ophthalmic suspension used for the treatment and prevention of eye inflammation and pain, especially following cataract surgery or other ocular procedures. Nepafenac is a prodrug that is converted within the eye to its active form, amfenac, which selectively inhibits COX-1 and COX-2 enzymes, thereby reducing the production of prostaglandins — the main cause of ocular pain and inflammation.

This makes Avanep highly effective in relieving redness, swelling, pain, and irritation of the eye. It is strictly for topical ophthalmic use only.

Uses

• Post-operative eye inflammation and pain (especially cataract surgery)

• Treatment of anterior uveitis (inflammation of the front eye structures)

• Relief of ocular pain, irritation, and redness

• May be prescribed for certain allergic conjunctivitis conditions under medical supervision

Dosage

• Typical dose: 1 drop in the affected eye(s), 2–3 times daily, or as prescribed by the ophthalmologist

• Start before surgery (if indicated) and continue after procedure as directed

• Do not self-medicate — always use under eye specialist supervision

How to Use

1. Wash hands thoroughly before application

2. Shake the bottle well

3. Tilt head back, pull down lower eyelid, and instill 1 drop into the eye

4. Do not touch the dropper tip to any surface or the eye to avoid contamination

5. Gently close the eye for 1–2 minutes without blinking to enhance absorption

6. If using other eye medications, wait at least 5–10 minutes between applications

In Case of Overdose

• Accidental ingestion or excessive instillation may cause: nausea, dizziness, severe eye irritation, or blurred vision

• Seek emergency medical help immediately if overdose is suspected

Missed Dose

• Instill as soon as remembered

• Skip if it’s nearly time for next dose — do not double dose

When Not to Use

Do not use Avanep if:

• You are allergic to Nepafenac, amfenac, or other NSAIDs

• You have ocular herpes simplex, corneal epithelial defects, or severe dry eye

• You have a history of NSAID-induced asthma, urticaria, or anaphylaxis

• You are wearing contact lenses (unless directed by a doctor during treatment)

Side Effects

Common:

• Mild burning or stinging sensation

• Blurred vision immediately after use

• Eye redness or irritation

• Sensitivity to light

Serious (seek medical attention):

• Corneal thinning or delayed healing

• Severe eye pain or sudden vision changes

• Allergic reaction (swelling, difficulty breathing)

Precautions & Warnings

• Strictly for ophthalmic use only

• Use with caution in patients with bleeding disorders or those on blood thinners

• Prolonged use may delay wound healing

• Avoid use with other topical NSAIDs or corticosteroids unless prescribed

• Pregnant and breastfeeding women should only use under doctor’s advice

Drug Interactions

• Other topical NSAIDs or corticosteroid eye drops → may increase corneal side effects

• Systemic NSAIDs → additive effect, increasing bleeding risk

• Anticoagulants (e.g., warfarin) → increased risk of bleeding

Storage & Disposal

• Store at 20–25°C (room temperature)

• Keep away from heat, light, and moisture

• Do not freeze

• Discard bottle 4 weeks after opening

• Keep out of reach of children

Quick Tips

• Shake well before each use

• Do not wear contact lenses during treatment unless approved by your doctor

• Apply drops at consistent times daily for best results

• Do not share eye drops with others

• Attend regular follow-up eye examinations

Laboratory Screening

Your ophthalmologist may recommend:

• Eye examination: to check healing, corneal clarity, and intraocular pressure

• Kidney and liver function tests in long-term therapy or systemic absorption risk

Doctor’s Review

“Nepafenac eye drops are highly effective in controlling post-surgical inflammation and pain, particularly after cataract procedures. They provide targeted relief and reduce recovery time. However, because these are NSAID-based drops, patients must use them strictly under supervision to avoid corneal complications. Self-medication is not advised.”
— Prof. Dr. Naeem Akhtar, MBBS, FCPS

Disclaimer

This information is provided for educational and product knowledge purposes only.
It is not a prescription. Always consult a qualified ophthalmologist or healthcare professional before starting, changing, or stopping Avanep (Nepafenac).