Axifen 50mg

Diclofenac Sodium 50mg is an NSAID that works by inhibiting cyclooxygenase (COX) enzymes, particularly COX-2, thereby reducing the production of prostaglandins — chemical mediators responsible for pain, inflammation, and fever. By blocking this pathway, diclofenac provides relief from swelling, stiffness, pain, and fever in various musculoskeletal and inflammatory conditions.

Uses

Diclofenac Sodium 50mg is prescribed for:

• Relief of acute pain (e.g., post-surgical pain, injury-related pain).

• Management of arthritis-related inflammation (osteoarthritis, rheumatoid arthritis, ankylosing spondylitis).

• Treatment of migraine attacks.

• Relief in acute gout flares.

• Menstrual pain (dysmenorrhea).

• Dental and post-operative pain management.

• Pain and swelling after minor surgeries or trauma.

Dosage

• Adults: 50mg two to three times daily after meals.

• Osteoarthritis & Rheumatoid Arthritis: 50mg every 8 hours or 75mg every 12 hours.

• Menstrual cramps: 50mg three times daily (first dose may be 100mg if needed).

• Migraine: 50mg oral solution as a single dose in water.

• Children (≥3 years, juvenile arthritis): 2–3 mg/kg/day divided in 2–3 doses.

Always follow your doctor’s prescription. Do not self-medicate.

In Case of Overdose

Overdose may cause nausea, vomiting, stomach pain, gastrointestinal bleeding, dizziness, or kidney/liver impairment. Seek immediate medical attention. Activated charcoal and supportive therapy may be used in hospitals.

How To Use

• Swallow the tablet whole with a glass of water.

• Take with food or milk to minimize stomach upset.

• Do not crush or chew.

• Use exactly as prescribed.

When Not to Use

Do not take Diclofenac Sodium 50mg if you have:

• Allergy to Diclofenac, aspirin, or other NSAIDs.

• History of asthma, hives, or severe allergic reactions to NSAIDs.

• Active or recurrent gastrointestinal ulcer/bleeding.

• Severe heart failure or recent heart attack.

• Severe kidney or liver impairment.

• Bleeding disorders or on blood thinners.

• Last trimester of pregnancy.

• Recent coronary artery bypass graft (CABG) surgery.

Side Effects

Common:

• Nausea, vomiting, diarrhea

• Stomach pain, indigestion

• Headache, dizziness

• Rash, itching

Serious (seek help):

• GI bleeding (black/tarry stools, vomiting blood)

• Severe allergic reaction (swelling, difficulty breathing)

• Elevated blood pressure, heart attack, or stroke risk

• Liver dysfunction (yellowing eyes/skin)

Precautions & Warnings

• Caution in patients with heart disease, high blood pressure, kidney disease, liver disease, or gastric ulcers.

• Long-term use increases risk of cardiovascular events.

• Monitor liver function, kidney function, and blood pressure with prolonged use.

• Avoid during pregnancy (3rd trimester) and breastfeeding unless prescribed.

• Elderly patients require careful monitoring.

Food Interactions

• Avoid alcohol (increases bleeding risk).

• Avoid grapefruit (affects drug metabolism).

• High-fat meals may delay absorption.

• Limit spicy/irritating foods that worsen gastric side effects.

Quick Tips

• Always take with food or milk.

• Do not combine with alcohol.

• Report any unusual bleeding, black stools, or persistent abdominal pain.

• Do not share this medicine with others.

• Use lowest effective dose for shortest possible duration.

Laboratory Screening

• Liver function tests (LFTs) for long-term users.

• Kidney function tests (Urea, Creatinine).

• Blood pressure monitoring.

• RA factor or ESR/CRP if prescribed for arthritis.

Doctor’s Review

“Diclofenac remains one of the most widely prescribed NSAIDs for arthritis, joint pain, and inflammatory conditions. It is effective in both acute and chronic musculoskeletal disorders. However, due to potential gastrointestinal and cardiovascular risks, it should be used at the lowest effective dose and under proper medical supervision.”
— Prof. Dr. Muhammad Asif Arif, MBBS, FCPS (Rheumatology & Pain Management Specialist)

Disclaimer

This information is provided for educational and product knowledge purposes only.
It is not a substitute for medical prescription. Always consult a qualified physician before starting, changing, or stopping Diclofenac Sodium 50mg.