Bevidox

Description

Neurobion Tablets, a Vitamin B Complex supplement, are used in Pakistan to support nervous system health and address deficiencies linked to neurological disorders like peripheral neuropathy. Containing B vitamins (B1, B6, B12), they act as co-factors in energy metabolism and nerve function, vital for patients with dietary deficiencies or conditions like diabetes, common in urban centers like Karachi or rural Punjab. Produced by Merck or similar brands, they’re available in strips of 10-30 tablets, priced around Rs. 200-300 per pack, prescription-optional but often recommended under medical guidance by DRAP-regulated pharmacies.

Product Specifications

• Name: Neurobion Tablets
• Generic: Vitamin B Complex (Thiamine/B1, Pyridoxine/B6, Cyanocobalamin/B12)
• Requires Prescription: No (but medical guidance advised)
• Packaging: Strip or bottle of 10-30 tablets
• Price: Approximately Rs. 200-300 per pack (varies by pharmacy; DRAP sets max retail prices)
• Storage: Keep at room temperature (15-25°C), away from light, heat, moisture, and children

How It Functions

Vitamin B Complex supports nerve health and energy production. Thiamine (B1) aids carbohydrate metabolism and nerve signal transmission. Pyridoxine (B6) supports neurotransmitter synthesis, reducing neuropathy symptoms. Cyanocobalamin (B12) promotes myelin formation and red blood cell production. Chemically, thiamine is 3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-5-(2-hydroxyethyl)-4-methylthiazolium chloride; pyridoxine is 5-hydroxy-6-methyl-3,4-pyridinedimethanol; cyanocobalamin is a cobalt-containing corrinoid. Effects build over weeks, with peak benefits in 1-2 months for deficiency correction.

Dosage Information

Adults: One tablet daily, swallowed whole with water, with or without food. For neurological disorders or severe deficiency, doctors may adjust to 1-2 tablets daily under supervision. Not typically for children unless prescribed. Take at the same time daily for consistency; duration varies (weeks to months) based on deficiency or condition. Consult physician for long-term use or if symptoms persist.

Side Effects

• Very Common (>1 in 10): Mild gastric upset (nausea, bloating)
• Common (up to 1 in 10): Mild rash, headache, metallic taste
• Rare: Allergic reactions (itching, swelling), insomnia, tingling, mood swings, abnormal blood pressure

Drug Interactions

May interact with:

• Antibiotics (e.g., tetracycline): Reduces B vitamin absorption
• Phenytoin, anti-seizure drugs: Lowers B6 levels, increasing seizure risk
• Levodopa: B6 reduces efficacy in Parkinson’s treatment
• Cisplatin: May exacerbate neuropathy or reduce B12 absorption
• Other supplements: Risk of excess vitamin intake; coordinate with physician

Indications

Approved for:

• Supporting nervous system function in neurological disorders (e.g., peripheral neuropathy)
• Correcting Vitamin B deficiencies due to diet, malabsorption, or chronic conditions
• Managing symptoms like numbness, tingling, or fatigue in diabetes or alcoholism

When Not to Use

Avoid in:

• Hypersensitivity to thiamine, pyridoxine, cyanocobalamin, or excipients
• Known allergic reactions to B vitamins or related compounds

Precautions

• Use cautiously in conditions impairing absorption (e.g., celiac disease, Crohn’s disease, ulcerative colitis, HIV, kidney disease).
• Monitor for allergic reactions; stop if rash or swelling occurs.
• Avoid high doses in pregnancy/breastfeeding without medical advice; excess B6 may cause neuropathy.
• Not a substitute for treating underlying causes of deficiency (e.g., diabetes, alcoholism).
• Buy from DRAP-registered pharmacies; check holograms to avoid counterfeits.
• Consult physician if taking multiple supplements to avoid overdose.

Warnings

• Overdose: High doses may cause nerve tingling, rash, or blood pressure changes; seek immediate care.
• Chronic conditions: Does not cure underlying diseases like diabetes; address root cause.
• B6 toxicity: Prolonged high doses (>200mg/day) may cause irreversible neuropathy.
• Allergic reactions: Rare but serious; stop and seek care for swelling or breathing issues.
• Kidney issues: Excess B vitamins may strain kidneys; monitor function in chronic disease.

Additional Notes

• Pregnancy Category: Consult physician; generally safe in recommended doses but avoid excess.
• Breastfeeding: Safe in moderation; monitor infant for side effects.
• Availability: Common in urban and rural pharmacies; generics like Bevidox available.
• Stability: Stable at room temperature; discard expired tablets.
• Reporting: Log batch for side effects; report to DRAP for quality control.

Doctor Review

Dr. Imran Qureshi, a neurologist in Lahore, notes Neurobion’s role in managing neuropathy symptoms in diabetic patients, common in Pakistan due to poor diet or chronic conditions. DRAP data supports its use for B vitamin deficiencies, but Dr. Qureshi emphasizes checking for underlying causes and avoiding high doses to prevent toxicity.

Disclaimer

This is general product information, not a prescription or medical advice. Consult your doctor or pharmacist for personal guidance.