Bofalgan 1gm

Description Bofalgan IV Infusion 1g/100ml contains Paracetamol (1g), an analgesic and antipyretic used for rapid relief when oral administration isn’t feasible. It exerts a central analgesic effect via descending serotonergic pathways and possibly by inhibiting prostaglandin synthesis or influencing cannabinoid receptors. This sterile solution is administered intravenously for mild to moderate pain and fever reduction, ideal for postoperative settings or when patients can’t swallow. Manufactured by Bosch Pharmaceuticals (Pvt) Ltd, it’s a clear, preservative-free infusion in a 100ml vial.

Ingredients Paracetamol 1g (10mg/ml).

Drug Class Non-Opioid Analgesic / Antipyretic.

Dosage Form IV Infusion (1 box = 1 vial of 100ml).

Uses Bofalgan IV Infusion is prescribed for:

• Relief of mild to moderate pain (e.g., postoperative, headache, dental).
• Reduction of fever in acute conditions.
• Adjunct in fever and cough associated with infections or inflammation.
• Management in patients unable to take oral forms (e.g., nausea, surgery).
• Short-term symptomatic treatment in adults and children over 33kg.

Doctor’s Review Anesthesiologists and general physicians favor Bofalgan for its quick onset and safety profile. As one expert states: “Bofalgan IV delivers fast pain and fever relief without opioid risks, peaking in plasma within 15 minutes. It’s a staple post-op, but dose vigilance prevents rare liver issues, especially in at-risk groups.”

Dosage (Follow physician’s instructions — typical guideline)

• Adults & adolescents over 50kg: 1g (1 vial) every 4-6 hours, max 4g/24 hours.
• Children 33-50kg: 15mg/kg (1.5ml/kg) every 6 hours, max 60mg/kg/24 hours.
• Infuse over 15 minutes; minimum 4-hour interval.
• Severe renal impairment (CrCl ≤30ml/min): Extend to 6 hours between doses.
• Do not exceed 4 doses in 24 hours; switch to oral when possible.

In Case of Overdose Overdose (>7.5g adults; >140mg/kg children) risks severe liver damage, including necrosis, metabolic acidosis, or coma. Symptoms appear 24-48 hours post-ingestion: nausea, vomiting, abdominal pain, jaundice. Seek emergency care immediately. Treatment: Activated charcoal if recent, N-acetylcysteine antidote within 8 hours, supportive liver care. Monitor liver enzymes and prothrombin time.

Missed Dose IV infusions are typically scheduled by healthcare providers, so misses are rare. If delayed, administer promptly without doubling. Consult your doctor to reschedule and avoid exceeding daily max to prevent accumulation.

How to Use

• Administer by slow IV infusion over 15 minutes via dedicated line.
• Dilute if needed in compatible fluids (e.g., 5% dextrose); do not mix with other drugs.
• Use aseptic technique; inspect for particles before use.
• For patients under 50kg, calculate dose by weight and discard excess.
• Transition to oral paracetamol once feasible for ongoing management.

When Not to Use Avoid Bofalgan if:

• Hypersensitive to paracetamol or excipients (e.g., previous rash or anaphylaxis).
• Severe hepatocellular insufficiency (e.g., active hepatitis).
• Chronic severe alcoholism or malnutrition (depleted glutathione).
• Concurrent use of other paracetamol-containing products.
• Neonates or premature infants without medical oversight.

Side Effects Common:

• Dizziness, headache.
• Nausea, vomiting, constipation, diarrhea.
• Injection site pain or reaction.

Uncommon / Severe (Stop and seek medical help):

• Serious skin reactions (SJS, TEN, AGEP: rash, blistering, peeling).
• Liver toxicity (jaundice, dark urine, abdominal pain).
• Blood disorders (anemia, hemorrhage).
• Allergic reactions (swelling, breathing difficulty).

Precautions & Warnings

• Discontinue at first sign of rash or hypersensitivity; educate on severe skin reaction risks.
• Higher liver damage risk in hepatic insufficiency, alcoholism, malnutrition, or dehydration—monitor LFTs.
• Use cautiously in Gilbert’s syndrome, anorexia, or cachexia (low glutathione).
• Avoid in severe renal/hepatic impairment; adjust intervals.
• Does not contain sodium >1mmol/100ml—suitable for low-sodium diets.

Drug Interactions

• Probenecid: Reduces paracetamol clearance, increasing levels.
• Enzyme inducers (barbiturates, isoniazid, carbamazepine, phenytoin, rifampicin): Enhance metabolism, reducing efficacy.
• Zidovudine, busulfan: Paracetamol may increase toxicity.
• Warfarin: May prolong INR; monitor coagulation.
• Amoxicillin/clavulanic acid, ethanol: Heighten liver risk.
• Salicylamide: Alters metabolism—avoid combinations.

Food Interactions

• None significant, as it’s IV; no dietary restrictions.
• Avoid alcohol during treatment to minimize liver strain.
• Maintain hydration to support renal clearance.

Storage/Disposal

• Store at room temperature (15-30°C), away from direct light and heat.
• Keep vial sealed until use; discard unused portions after opening.
• Out of reach of children; use within 6 hours at room temp post-reconstitution if diluted.
• Dispose via medical waste protocols; do not flush.

Quick Tips

• Track doses to avoid overlap with other paracetamol sources.
• Report abdominal pain or yellowing skin immediately.
• Stay hydrated to ease GI side effects.
• Use sunscreen if photosensitivity occurs (rare).
• Switch to oral form ASAP for convenience.

Disclaimer This information is provided for educational purposes only and does not replace medical advice. Use only under the supervision of a licensed physician. Do not self-medicate