Deprel

Description

Deprel 50mg contains Trazodone HCl, an antidepressant that acts by affecting serotonin levels in the brain. It is used in the management of depression, particularly when accompanied by anxiety or sleep disturbance. Unlike some other antidepressants, it has relatively lower anticholinergic effects, which may reduce certain unwanted reactions.

Uses

• Treatment of depression.

• May also be used where depression includes anxiety or agitation.

Dosage

To be taken as prescribed by a qualified healthcare professional.

In Case of Overdose

Signs may include confusion, seizure, fainting, or heart rhythm changes. Seek emergency medical support immediately.

Missed Dose

Take when remembered unless close to next dose. Do not double.

How to Use

Swallow with water, preferably at the same time daily. May be taken after food to reduce stomach upset.

When Not to Use

Avoid in:

• Known allergy to Trazodone or its ingredients.

• Recent heart attack.

• Heavy alcohol use or concurrent use of sedatives.

• Patients under 18 years of age.

Side Effects

Reported effects may include:

• Thoughts of self-harm (requires monitoring).

• Drowsiness or dizziness.

• Irregular heartbeat.

• Anaemia-related tiredness.

• Numbness or tingling sensations.

• Shaking, sweating, confusion, or hallucinations (possible serotonin-related reaction).

• Rare: Neuroleptic Malignant Syndrome (high fever, muscle rigidity).

Precautions & Warnings

• Do not stop abruptly — withdrawal effects may include irritability or sleep disturbance.

• Elderly individuals may be more sensitive to side effects.

• Sedation may occur — avoid driving or machinery use until individual response is known.

• Initial treatment phase may temporarily increase anxiety or self-harm thoughts.

Drug Interactions

Use caution with:

• MAO inhibitors (e.g., selegiline, phenelzine).

• Other antidepressants (SSRIs, tricyclics).

• Sedatives or sleeping pills.

• Antihypertensives (clonidine, digoxin).

• Epilepsy medicines (carbamazepine, phenytoin).

• Antifungals (ketoconazole, itraconazole).

• HIV medicines (ritonavir, indinavir).

• Blood thinners (warfarin).

• Levodopa, phenothiazines, or St. John’s Wort.

Food Interactions

Alcohol should be avoided, as it may increase sedation.

Storage

Store at room temperature, away from heat, sunlight, and moisture.

Doctor Review

Trazodone is commonly regarded as useful in patients where depression coexists with poor sleep or restlessness. Clinicians generally monitor closely during early treatment due to possible mood fluctuations or sedation.

Disclaimer

This is general product information only. It should not be used as medical advice or a substitute for professional consultation.