Difene

Difene 75 mg contains Diclofenac Sodium, a widely used NSAID for the relief of pain and inflammation. The “dual release” design ensures both immediate and sustained action, helping to control pain over a longer duration. It does not contain steroids.

Uses

Difene is generally used for:

• Arthritis (including rheumatoid arthritis, osteoarthritis)

• Painful swelling or inflammation of joints, tendons, and ligaments

• Back pain, sprains, strains, or sports injuries

• Acute gout attacks

• Period pain (dysmenorrhea)

• Pain and inflammation after surgery

How to Use

• Take the capsule whole with water or milk, preferably with food.

• Do not chew, crush, or break the capsule.

• The usual dose: 1–2 capsules daily, divided into morning and evening doses.

• Maximum recommended: 150 mg per day.

• Not recommended in children and adolescents.

• Elderly patients should use the lowest effective dose.

When Not to Use

Avoid Difene if you:

• Are allergic to diclofenac, aspirin, or other NSAIDs.

• Have or ever had stomach ulcers, bleeding, or perforation.

• Have heart problems (heart attack, stroke, severe heart failure).

• Suffer from serious liver or kidney disease.

• Have blood clotting or circulation problems.

• Are in the last trimester of pregnancy.

Precautions & Warnings

• Long-term or high-dose use may increase the risk of heart attack or stroke.

• May irritate the stomach — take with meals.

• Use cautiously if you have high blood pressure, asthma, diabetes, or Crohn’s disease.

• Avoid alcohol while taking Difene as it increases stomach risk.

• Tell your doctor if you are using blood thinners, steroids, or heart medications.

Possible Side Effects

Common:

• Headache, dizziness

• Nausea, stomach pain, indigestion

• Rash or skin irritation

Rare but Serious:

• Stomach bleeding (black stools, vomiting blood)

• Allergic reaction (swelling of face, lips, difficulty breathing)

• Severe skin reactions (Stevens-Johnson Syndrome)

• Liver or kidney problems

• Increased risk of heart attack or stroke

Stop use and seek medical attention if severe symptoms occur.

Storage

• Store below 25°C in a cool, dry place.

• Keep in original packaging.

• Protect from light and moisture.

• Keep out of reach of children.

Doctor’s Review

Dr. Hassan Raza, MBBS – Consultant Orthopedic Specialist
“In my practice, Difene 75 mg is highly effective for arthritis and musculoskeletal pain. The dual release form helps provide sustained relief throughout the day. However, I always remind patients to take it after meals and avoid prolonged use without medical supervision, as it may affect the stomach or heart in some cases.”

Disclaimer

This information is provided for educational and product awareness purposes only. It is not a prescription. Always consult a qualified doctor or pharmacist before starting or adjusting any medication.