Dowtor

Dowtor is a fixed-dose combination of Amlodipine (a calcium channel blocker) and Valsartan (an angiotensin II receptor blocker). Together, these medicines help relax and widen blood vessels, which lowers blood pressure and improves blood flow. This combination is widely used in Pakistan to manage hypertension and reduce cardiovascular risks.

Primary Uses

Dowtor is commonly prescribed for:

• Hypertension (high blood pressure) management.

• Reduction of cardiovascular risks. (such as stroke or heart attack)

• Support in controlling blood pressure in patients not managed by single-drug therapy.

• Relief of symptoms related to heart strain or left ventricular hypertrophy.

Side Effects

Some people may experience:

• Dizziness or headache.

• Fatigue or weakness.

• Nausea, constipation, or abdominal discomfort.

• Swelling of hands, feet, or ankles. (due to Amlodipine)

Less common but serious effects:

• Sudden weight gain or swelling. (fluid retention)

• Severe allergic reactions. (face, lip, or throat swelling)

• Kidney function changes. (linked to Valsartan)

• Rare liver-related problems.

Precautions & Warnings

• Not suitable for patients with allergy to Amlodipine, Valsartan, or related medicines.

• Avoid use in pregnancy, as Valsartan may cause harm to the fetus.

• Use cautiously in patients with liver or kidney disease.

• Elderly patients should be monitored closely due to increased sensitivity.

• Avoid combining with medicines that affect potassium levels (e.g., potassium supplements, certain diuretics).

• Alcohol may enhance blood pressure-lowering effects.

Contraindications

• Severe liver impairment.

• Advanced kidney disease without close supervision.

• Low blood pressure. (hypotension)

• Known hypersensitivity to either active ingredient.

Drug Interactions

Dowtor may interact with:

• Other antihypertensives. (enhanced BP-lowering effect)

• NSAIDs. (may reduce kidney function when combined with Valsartan)

• Potassium supplements / potassium-sparing diuretics. (risk of high potassium)

• Certain antifungal or antibiotic medicines that interfere with metabolism.

Storage & Handling

• Store at room temperature (20–25°C).

• Protect from moisture and direct sunlight.

• Keep out of reach of children.

• Do not use after expiry date.

FAQs

Q: What is Dowtor used for?
A: It is prescribed for controlling high blood pressure and lowering cardiovascular risks.

Q: Can Dowtor be taken with food?
A: Yes, it can be taken with or without food.

Q: Is it safe during pregnancy?
A: No, Valsartan may cause fetal harm; it should not be used during pregnancy.

Q: Does it affect kidney function?
A: In some patients, long-term use may affect kidney function, so periodic monitoring is advised.

Doctor’s Review
Dr. Hassan Raza, MBBS, FCPS – Cardiology

“Dowtor combines Amlodipine and Valsartan to help manage high blood pressure, particularly in patients whose condition is not controlled with a single medicine. Amlodipine works by relaxing blood vessels, while Valsartan helps reduce strain on the heart through its effect on the renin-angiotensin system. Together, they support blood pressure control and long-term cardiovascular protection. Common side effects may include dizziness or ankle swelling, and ongoing monitoring of kidney function and electrolytes is important for safe, long-term use. Overall, Dowtor is considered an effective and well-tolerated option for hypertension management.”

Disclaimer
This information is provided for educational and product awareness purposes only. It is not a medical prescription. Always consult a qualified physician or cardiologist before starting or adjusting any medication.