Duride

Duride contains Isosorbide-5-Mononitrate (ISMN), a long-acting nitrate that relaxes and widens blood vessels. By improving blood flow and reducing the heart’s workload, it helps prevent chest pain (angina) associated with coronary artery disease. Unlike short-acting nitrates, Duride provides longer protection and is often used for maintenance therapy.

Primary Uses

Duride is commonly prescribed for:

• Prevention of angina pectoris (chest pain due to reduced heart blood supply)

• Long-term management of coronary artery disease

• Adjunct therapy in heart failure (under specialist care)

Side Effects

Some patients may experience:

• Headache (common at the start of therapy)

• Dizziness or lightheadedness

• Low blood pressure (hypotension)

• Flushing or warmth of the face

• Nausea

Serious but rare effects:

• Fainting spells

• Severe allergic reaction

• Very low blood pressure with high doses or drug interactions

Precautions & Warnings

• Avoid use with phosphodiesterase inhibitors (e.g., sildenafil, tadalafil) as this may cause dangerously low blood pressure.

• Use cautiously in patients with low blood pressure, dehydration, or recent heart attack.

• May impair ability to drive or operate machinery due to dizziness.

• Gradual withdrawal is advised; sudden stopping may worsen angina.

• Pregnant or breastfeeding women should consult their doctor before use.

Contraindications

• Known allergy to nitrates

• Use with erectile dysfunction medicines (sildenafil, vardenafil, tadalafil)

• Severe hypotension or shock

• Recent intracranial bleeding or head injury

FAQs

Q: What is Duride mainly used for?
A: It is used to prevent angina (chest pain) in patients with coronary artery disease.

Q: Can Duride be used during an acute chest pain attack?
A: No, it is for prevention. Acute attacks are managed with fast-acting nitrates like nitroglycerin.

Q: Does it lower blood pressure?
A: Yes, it relaxes blood vessels and can lower blood pressure, so dizziness may occur.

Q: Can I stop Duride suddenly?
A: No, stopping abruptly may worsen angina. Discontinuation should be gradual under medical supervision.

Storage & Handling

• Store at room temperature (below 30°C).

• Protect from heat, moisture, and light.

• Keep out of reach of children.

• Do not use after expiry date.

Doctor’s Review
Dr. Asad Malik, MBBS, FCPS – Cardiology

“Duride (Isosorbide-5-Mononitrate) is used in the long-term management of stable angina and coronary artery disease. By helping to relax blood vessels, it reduces the frequency of angina attacks and improves exercise tolerance. Headaches are a common initial side effect, though they often lessen with continued use. Careful attention is needed to avoid drug interactions, particularly with medicines for erectile dysfunction, as these can lead to severe drops in blood pressure. With appropriate monitoring, Duride serves as a reliable option for the ongoing prevention of angina symptoms.”

Disclaimer
This information is provided for educational and product awareness purposes only. It is not a medical prescription. Always consult a qualified physician or cardiologist before starting or adjusting any cardiac medication.