Elixime

Cefixime 400mg capsules exhibit their antibacterial activity through a precise mechanism of action. Cefixime works by inhibiting bacterial cell wall synthesis. It binds to and blocks the activity of penicillin-binding proteins (PBPs), which are key enzymes responsible for cross-linking peptidoglycan strands in the bacterial cell wall. Without this cross-linking, the bacterial cell wall weakens, resulting in cell lysis and death of the bacteria. This mechanism is particularly effective against susceptible organisms, making Cefixime an established choice for a wide range of bacterial infections.

Ingredients

• Cefixime 400mg

Drug Class

• Cephalosporin antibiotic

Uses

Cefixime 400mg Capsules are used for:

• Respiratory tract infections such as pneumonia and bronchitis.

• Urinary tract infections (UTIs).

• Skin and soft tissue infections.

• Bone and joint infections.

• Preventing and managing infections around surgical procedures.

• Treating severe infections where high-dose antibiotics are required.

Dosage

• Adults (e.g., chronic bronchitis, otitis media, gonorrhea, urinary tract infection): 400mg daily in divided doses every 12–24 hours.

• Children 6 months to 12 years (weight ≤45kg): 8mg/kg/day, in single or divided doses.

• Children above 12 years or weight >45kg: 400mg once daily.

Dosage must always be as directed by the prescribing doctor.

In Case of Overdose

Symptoms may include nausea, vomiting, diarrhea, and abdominal discomfort. Seek medical attention immediately. Supportive care and monitoring of vital signs are usually required.

Missed Dose

Take the missed dose as soon as you remember. If it is nearly time for your next dose, skip the missed one. Do not double the dose. For repeated missed doses, consult your doctor.

How To Use

Swallow the capsule whole with a glass of water, at the same time each day. Can be taken with or without food, as advised by your healthcare provider.

When Not to Use

Avoid Cefixime 400mg Capsules if:

• You are allergic to Cefixime or other cephalosporin antibiotics.

• You have a history of severe gastrointestinal disorders (especially colitis).

• You suffer from severe kidney impairment.

• You had a severe allergic reaction to medications in the past.

• The patient is below 6 months of age.

Side Effects

Possible side effects include:

• Diarrhea, nausea, vomiting.

• Abdominal pain or bloating.

• Headache or dizziness.

• Rash, itching, or allergic skin reactions.

• Vaginal yeast infection.

• Fatigue.

Precautions & Warnings

• Inform your doctor if you have kidney problems, gastrointestinal issues, or history of allergies.

• May reduce effectiveness of hormonal contraceptives — additional precautions may be required.

• Use cautiously in pregnancy or breastfeeding, only when prescribed.

• Elderly patients may require closer monitoring.

• Do not consume alcohol during treatment.

Drug Interactions

• Probenecid may increase blood levels of Cefixime.

• Concurrent use with nephrotoxic drugs increases kidney risk.

• May reduce effectiveness of oral contraceptives.

• Antacids and iron supplements reduce absorption (take 2 hours apart).

• May increase bleeding risk with anticoagulants (e.g., warfarin).

• Caution when combined with aminoglycoside antibiotics.

Food Interactions

• Avoid alcohol (can worsen side effects).

• Dairy products may reduce absorption (take at least 2 hours apart).

• Grapefruit may alter drug metabolism.

• High-fat meals can delay absorption.

• Iron-rich foods and Vitamin C supplements may interfere with absorption.

Storage/Disposal

• Store in a cool, dry place at room temperature.

• Keep away from heat, moisture, and sunlight.

• Do not use beyond expiry date.

• Dispose safely through a pharmacist; do not flush in drains.

• Keep out of reach of children.

Quick Tips

• Complete the full prescribed course even if symptoms improve.

• Take at the same time daily for best effect.

• Do not crush or chew the capsule.

• Maintain hydration during treatment.

• Report any severe diarrhea, rash, or allergic symptoms immediately.

Laboratory Screening

• Blood culture for infection confirmation.

• TyphiDot IgM test for suspected typhoid fever.

• Renal function tests to monitor kidney health.

• CBC (complete blood count) to track risk of anemia.

Doctor’s Review

Dr. Hammad Ali, MBBS, FCPS 
Cefixime 400mg in selected cases of respiratory, urinary, and ENT infections where the bacteria are known to be sensitive. Its once-daily option is helpful for patient compliance. I monitor closely for diarrhea, rashes, or allergic reactions and adjust the dose for patients with kidney impairment. Patients need that they must complete the full course, even if symptoms improve early.Cefixime is effective and well tolerated when prescribed appropriately.

Disclaimer

This information is provided for educational and product reference purposes only. It is not a substitute for medical advice or a prescription. Always consult a licensed physician or pharmacist before starting or adjusting any medication.