Adapalene cream works by modulating cellular keratinization and controlling the inflammatory process. Its anti-inflammatory activity is linked to inhibition of lipooxygenase activity and interference with oxidative metabolism of arachidonic acid. This helps in reducing acne lesions, preventing new breakouts, and improving skin texture over time.
Ingredients
Adapalene
Drug Class
Retinoids
Dosage Form
Cream
Uses
Adapalene cream is commonly used for:
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Treating acne and reducing associated inflammation.
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Preventing the formation of new acne lesions.
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Promoting skin cell turnover for healthier skin.
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Improving skin texture and tone.
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Reducing comedones (blackheads and whiteheads).
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Supporting treatment of mild to moderate acne.
Dosage
To be used strictly as directed by your doctor or dermatologist.
In Case of Overdose
Applying too much can lead to skin redness, irritation, or scaling. Wash the area and consult your doctor for further advice.
Missed Dose
If you forget to apply, do not double the quantity. Apply the next scheduled dose normally.
How To Use
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Wash your hands and cleanse the affected area before application.
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Apply a thin layer of cream once daily, preferably in the evening.
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Do not rub harshly; spread gently on the skin.
When Not to Use
Avoid use if you have:
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Open wounds, broken skin, or eczema.
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Severe sunburn.
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Known allergy to Adapalene or other Vitamin A derivatives.
Side Effects
Possible side effects include:
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Mild skin irritation, redness, or dryness.
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Temporary stinging or burning sensation.
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Scaling or peeling of skin.
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Increased sensitivity to sunlight.
Precautions & Warnings
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Avoid excessive sun exposure and always use sunscreen.
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Do not apply on broken or eczematous skin.
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Inform your doctor if you are using other topical acne medications.
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Pregnant or breastfeeding women should consult a physician before use.
Drug Interactions
Adapalene may interact with:
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Salicylic acid.
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Benzoyl peroxide.
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Other drying agents.
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Chemical exfoliants or scrubs.
Storage/Disposal
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Store at room temperature, away from heat, moisture, and light.
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Keep tightly closed and out of reach of children.
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Dispose of safely; do not flush in drains.
Quick Tips
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Wash face with a mild cleanser before applying.
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Do not rub vigorously.
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Use clean hands for application.
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Apply moisturizer if dryness occurs.
Doctor’s Review
Dr. Hammad Ali, MBBS, FCPS
“Adapalene cream for patients with mild to moderate acne. It effectively reduces blackheads and pimples by promoting skin turnover. Patients use it at night and always apply sunscreen during the day, as the skin may become sensitive. Initial dryness or irritation is common but usually settles after consistent use. Compliance is key to seeing long-term benefits.”
Disclaimer
This information is provided for educational and product reference purposes only. It is not a substitute for professional medical advice or a prescription. Always consult a licensed physician or pharmacist before starting or adjusting any medication.

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