Estezene

Description Estezene 1mg tablets contain trifluoperazine hydrochloride, a piperazine phenothiazine with strong antipsychotic, anxiolytic, and antiemetic effects. It works by blocking dopamine receptors in the brain, reducing symptoms of schizophrenia, anxiety, and nausea. Its moderate sedative and hypotensive properties, along with a tendency for extrapyramidal reactions, make it effective but require careful use. In Pakistan, it’s prescribed under strict medical supervision per Pakistan Medical Association guidelines for mental health and related conditions.

Ingredients Trifluoperazine Hydrochloride.

Drug Class Phenothiazine Antipsychotic.

Dosage Form Tablet.

Requires Prescription Yes.

Uses In Pakistan, Estezene 1mg is used for:

• Managing schizophrenia and related disorders at higher doses to prevent relapses.
• Short-term treatment of anxiety and depression at low doses.
• Controlling nausea and vomiting.
• Stabilizing mood in severe psychiatric conditions.

Doctor’s Review Dr. Rabeya Tufail, MBBS from Ziauddin University and Managing Editor at CureCartDirect, states: “Estezene 1mg tablets are effective for schizophrenia, helping control symptoms like hallucinations. At lower doses, they also manage anxiety and nausea, but close monitoring is needed due to possible side effects like movement disorders.”

Dosage Take as prescribed by your doctor. Low doses (1–2 mg daily) are used for anxiety or nausea; higher doses (up to 6 mg daily, split) for schizophrenia. Swallow tablets whole with water, ideally at the same time daily. Follow medical guidance closely.

In Case of Overdose Overdose may cause dizziness, low blood pressure, drowsiness, or severe movement issues. Seek immediate medical help in Pakistan. Contact a doctor or poison control for urgent care, which may include monitoring or supportive treatment.

Missed Dose Take a missed dose as soon as remembered unless it’s near the next dose—then skip it. Don’t double up to avoid serious side effects. Use reminders to stay consistent.

How to Use Swallow the tablet whole with water, as directed by your doctor, preferably at consistent times daily.

When Not to Use Avoid Estezene 1mg if you have:

• Allergy to trifluoperazine or other phenothiazines.
• Liver problems or blood disorders.
• Heart failure causing breathlessness or ankle swelling.
• A coma, especially if caused by central nervous system depressants.

Side Effects Possible side effects include:

• Drowsiness, insomnia, or dizziness.
• Movement issues (parkinsonism, dystonias, dyskinesias).
• Low white blood cells or platelets, high prolactin levels.
• Fast heart rate, low blood pressure, rash, itching.
• Dry mouth, constipation, appetite loss, depression.
• Rarely: seizures, blood disorders, jaundice, neuroleptic malignant syndrome. Report severe or persistent effects to your doctor.

Precautions & Warnings Pakistan’s medical guidelines advise:

• Watch for venous thromboembolism (VTE) risks; identify and manage factors before and during use.
• Stop treatment if signs of tardive dyskinesia or neuroleptic malignant syndrome appear.
• Use cautiously in Parkinson’s disease, as symptoms may worsen, and levodopa effects may reverse.
• Be careful with epilepsy, as it may lower seizure threshold—avoid metrizamide.
• Avoid in narrow-angle glaucoma, myasthenia gravis, or prostate enlargement due to mild anticholinergic effects.
• Stopping abruptly may cause nausea, vomiting, or insomnia—taper off gradually.
• Consult your doctor if pregnant, planning pregnancy, or breastfeeding.

Drug Interactions Inform your doctor about all medications. Key interactions include:

• Strong painkillers (e.g., codeine) or blood pressure meds (e.g., guanethidine)—increase low blood pressure risk.
• Anticholinergics (e.g., atropine, procyclidine)—worsen side effects like dry mouth.
• Antidepressants (e.g., phenothiazines, lithium) or anticonvulsants—heighten side effects.
• Parkinson’s meds (e.g., levodopa)—reduced effectiveness.
• Anticoagulants (e.g., warfarin) or desferrioxamine—altered effects.
• Heart meds (e.g., quinidine, amiodarone) or diuretics—risk of heart rhythm or electrolyte issues.

Food Interactions

• No major food interactions, but avoid alcohol to prevent increased sedation or low blood pressure.
• Maintain a balanced diet to support overall health, especially with long-term use.
• Consult your doctor if on a specific diet for medical conditions.

Storage/Disposal Store at room temperature, away from direct light, heat, and moisture, in the original container, tightly sealed. Avoid bathrooms. Dispose of expired or unused tablets per pharmacist or local waste guidelines to prevent environmental harm. Keep out of reach of children and pets.

Control Drug Yes

Quick Tips

• Take exactly as prescribed, at the same time daily.
• Report movement issues, fever, or confusion immediately.
• Avoid alcohol to reduce side effects.
• Don’t stop suddenly—taper with doctor guidance.
• Inform your doctor of all meds to avoid interactions.
• Store in a cool, dry place, away from sunlight.

Disclaimer This is product information on Estezene (trifluoperazine hydrochloride), not a medical prescription. Consult a qualified Pakistani doctor for diagnosis, treatment, or dosing. Do not self-medicate based on this content.