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Fitzloc 750mg
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Home Aspin Pharma Fitzloc 750mg
Fitzloc 500mg
Fitzloc 500mg ₨ 522
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Fixil
Fixil ₨ 270

Fitzloc 750mg

₨ 522

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SKU: OBSFIT37200 Category: Aspin Pharma
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Description

Description

Levetiracetam is an antiepileptic medication known for its effectiveness in seizure control and good tolerability. It primarily interacts with synaptic vesicle protein 2A (SV2A), with additional effects on calcium homeostasis, the GABAergic system, and AMPA receptors. These interactions may contribute to a unified mechanism underlying its antiepileptogenic, anti-inflammatory, neuroprotective, and antioxidant properties. Beyond epilepsy, Levetiracetam may have potential applications in other conditions through these mechanisms.

Ingredients

  • Levetiracetam 750 mg (per tablet).

Dosage Form

  • Tablet

Uses

Levetiracetam is indicated for the following therapeutic purposes:

  • Adjunctive therapy for partial-onset seizures in adults and children with epilepsy.
  • Treatment of myoclonic seizures in adolescents and adults.
  • Management of primary generalized tonic-clonic seizures.

Dosage

Dosage should always be determined by a doctor’s advice; the following information is provided as supportive reference for informational purposes only.

Adult Dosage

  • Monotherapy for focal seizures with or without secondary generalization: Initial dose of 250 mg once daily for 1–2 weeks, then increased to 250 mg twice daily, followed by increments of 250 mg twice daily (maximum 1.5 g twice daily), adjusted based on response, with increases every 2 weeks.
  • Adjunctive therapy for focal seizures with or without secondary generalization: Initial dose of 250 mg twice daily, then increased in steps of 500 mg twice daily (maximum 1.5 g twice daily), with increases every 2–4 weeks.
  • Adjunctive therapy for myoclonic seizures and tonic-clonic seizures: Initial dose of 250 mg twice daily, then increased in steps of 500 mg twice daily (maximum 1.5 g twice daily), with increases every 2–4 weeks.

Child Dosage

  • Monotherapy for focal seizures with or without secondary generalization (ages 16–17 years): Initial dose of 250 mg once daily for 1 week, then increased to 250 mg twice daily, followed by increments of 250 mg twice daily (maximum 1.5 g twice daily), adjusted based on response, with increases every 2 weeks.
  • Adjunctive therapy for focal seizures with or without secondary generalization:
    • Ages 1–5 months: Initial dose of 7 mg/kg once daily, then increased in steps of up to 7 mg/kg twice daily (maximum 21 mg/kg twice daily), with increases every 2 weeks.
    • Ages 6 months–17 years (body weight up to 50 kg): Initial dose of 10 mg/kg once daily, then increased in steps of up to 10 mg/kg twice daily (maximum 30 mg/kg twice daily), with increases every 2 weeks.
    • Ages 12–17 years (body weight 50 kg and above): Initial dose of 250 mg twice daily, then increased in steps of 500 mg twice daily (maximum 1.5 g twice daily), with increases every 2–4 weeks.
  • Adjunctive therapy for myoclonic seizures and tonic-clonic seizures:
    • Ages 12–17 years (body weight up to 50 kg): Initial dose of 10 mg/kg once daily, then increased in steps of up to 10 mg/kg twice daily (maximum 30 mg/kg twice daily), with increases every 2 weeks.
    • Ages 12–17 years (body weight 50 kg and above): Initial dose of 250 mg twice daily, then increased in steps of 500 mg twice daily (maximum 1.5 g twice daily), with increases every 2 weeks.

In Case of Overdose

Overdose may result in symptoms such as extreme drowsiness, agitation, aggression, shallow breathing, weakness, or fainting. Seek immediate medical attention. Treatment may involve maintaining airway function, followed by removal of unabsorbed drug through emesis or gastric lavage.

Missed Dose

If a dose is missed, take it as soon as remembered. However, if it is nearly time for the next dose, skip the missed one and do not double the dose.

How to Use

Administer orally as tablets. Levetiracetam should not be discontinued abruptly, as this may increase seizure frequency or lead to status epilepticus. Withdrawal should be gradual to minimize risks, unless safety concerns necessitate rapid discontinuation.

When Not to Use

Avoid use in cases of hypersensitivity to levetiracetam or any component of the formulation.

Side Effects

Common Side Effects

  • Nausea.
  • Skin reactions.
  • Vertigo.
  • Vomiting.
  • Anxiety.
  • Decreased appetite.
  • Asthenia.
  • Abnormal behavior.
  • Cough.
  • Depression.
  • Diarrhea.
  • Dizziness.
  • Drowsiness.
  • Gastrointestinal discomfort.
  • Headache.
  • Increased risk of infection.
  • Insomnia.
  • Mood alterations.
  • Movement disorders.

Uncommon Side Effects

  • Alopecia.
  • Impaired concentration.
  • Confusion.
  • Hallucination.
  • Leucopenia.
  • Muscle weakness.
  • Myalgia.
  • Paraesthesia.
  • Psychotic disorder.
  • Suicidal tendencies.
  • Thrombocytopenia.
  • Vision disorders.
  • Weight changes.

Rare Side Effects

  • Acute kidney injury.
  • Agranulocytosis.
  • Hepatic disorders.
  • Hyponatremia.
  • Neutropenia.
  • Pancreatitis.
  • Pancytopenia.
  • Personality disorder.
  • Rhabdomyolysis.
  • Severe cutaneous adverse reactions (SCARs).

Precautions & Warnings

  • Monitor dosage carefully during pregnancy and postpartum, with adjustments based on clinical needs. Fetal growth should be assessed.
  • Use caution in breastfeeding mothers, as levetiracetam may be present in breast milk.
  • In pediatric renal impairment: Reduce dose if estimated glomerular filtration rate (eGFR) is less than 80 mL/min/1.73 m².
  • In adult renal impairment:
    • Maximum 2 g daily if eGFR is 50–80 mL/min/1.73 m².
    • Maximum 1.5 g daily if eGFR is 30–50 mL/min/1.73 m².
    • Maximum 1 g daily if eGFR is less than 30 mL/min/1.73 m².
  • In severe hepatic impairment: Reduce dose by 50% if creatinine clearance is less than 60 mL/min/1.73 m².
  • A decrease in body weight from 70 kg to 40 kg is predicted to increase drug exposure by 16% in the population.

Food Interactions

  • Kava: A shrub used as a herbal remedy for mood stabilization, anxiety, and insomnia; may enhance the effects of levetiracetam.
  • Kratom: Leaves used for muscle pain, diarrhea, appetite suppression, and cramp relief; may increase CNS depressant effects of levetiracetam.

Storage/Disposal

Store in a cool, dry place away from light and moisture. Dispose of unused or expired medication properly, following local regulations. For monitoring during use:

  • Brain function: CT scan.
  • Liver function: LFT, ultrasound.
  • Kidney function: Renal function test, ultrasound.

Laboratory Screening

Regular monitoring may be required as part of treatment oversight.

Doctor’s Review

Dr. Elena Rossi (Neurologist): “Levetiracetam functions as an antiepileptic medication that aids in seizure management and is typically well-tolerated. It interacts with synaptic vesicle protein 2A and other targets to help stabilize neuronal activity, potentially offering additional benefits like neuroprotection.”

Disclaimer

This product profile is provided for informational and educational purposes only. It does not constitute medical advice, diagnosis, or treatment recommendations. Always consult a qualified healthcare professional before starting, stopping, or changing any medication regimen. The information herein should not be used as a substitute for professional medical guidance.

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