Floxer

General Description

Floxer Tablet 500 mg contains Levofloxacin, a broad-spectrum antibacterial agent belonging to the fluoroquinolone class. It acts by inhibiting bacterial DNA replication, effectively halting bacterial cell division and growth. This medication is typically used for the treatment of a wide range of bacterial infections affecting the urinary tract, respiratory system, skin, and soft tissues.
Due to its strong bactericidal activity and good tissue penetration, it is often used under medical supervision for infections that are resistant to other antibiotics.

Pharmacological Classification

• Generic Name: Levofloxacin

• Brand Name: Floxer

• Drug Class: Fluoroquinolone Antibiotic

• Therapeutic Category: Antibacterial Agent

• Dosage Form: Film-coated Tablet

• Strength: 500 mg

• Prescription Requirement: Yes

Mechanism of Action

Levofloxacin works by inhibiting two essential bacterial enzymes — DNA gyrase and topoisomerase IV. These enzymes are crucial for DNA replication, repair, and transcription.
By blocking these enzymes, Levofloxacin prevents bacterial DNA from unwinding and duplicating, leading to bacterial cell death.
This mechanism is effective against a wide range of Gram-positive and Gram-negative organisms.

Pharmacokinetics

• Absorption: Rapidly and almost completely absorbed after oral administration.

• Bioavailability: Approximately 99%.

• Peak Plasma Concentration: Within 1 to 2 hours after dosing.

• Metabolism: Minimally metabolized; primarily excreted unchanged in urine.

• Half-life: 6–8 hours (prolonged in renal impairment).

• Elimination: Mainly renal (87% unchanged).

Clinical Function / Uses

Floxer 500 mg is prescribed for the treatment of infections caused by susceptible bacteria, including:

• Cystitis (Urinary Tract Infection): Effective against E. coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Enterococci.

• Pyelonephritis (Kidney Infection): Controls infection spread from the bladder to the kidneys.

• Nongonococcal Urethritis: Reduces inflammation and infection in the urethra.

• Skin and Soft Tissue Infections: Used for conditions such as cellulitis, abscesses, and wound infections caused by Staphylococcus aureus and Streptococcus pyogenes.

• Community-acquired Pneumonia: Active against Streptococcus pneumoniae and Haemophilus influenzae.

• Bronchitis: Useful in bacterial bronchitis due to Mycoplasma pneumoniae and Haemophilus influenzae.

• Inhalation Anthrax: Indicated as part of therapy for anthrax exposure.

• Plague: Active against Yersinia pestis in rare but severe infections.

Dosage

Each tablet contains Levofloxacin 500 mg.
Dosage varies based on infection type, severity, and renal function.
Administration should follow a doctor’s prescription only.

• Can be taken with or without food.

• Do not double doses if a dose is missed.

• Complete the full course even if symptoms improve to prevent resistance.

Onset & Duration

• Onset of Action: Within 1 to 2 hours post-ingestion.

• Duration: Approximately 24 to 32 hours per dose.

Adverse Effects

Commonly Reported:

• Gastrointestinal upset (nausea, abdominal pain, diarrhea)

• Headache, dizziness, insomnia

• Mild rise in liver enzymes

• Joint or muscle pain

Serious Adverse Reactions (Require Immediate Medical Attention):

• Tendon disorders (pain, swelling, rupture) – discontinue immediately

• Peripheral neuropathy (numbness, tingling, or weakness)

• CNS symptoms (confusion, hallucinations, tremors, seizures)

• Severe skin reactions (Stevens–Johnson syndrome, toxic epidermal necrolysis)

• Liver injury or jaundice

• QT prolongation (irregular heart rhythm)

• Severe diarrhea caused by Clostridium difficile overgrowth

Drug Interactions

Levofloxacin interacts with a wide range of drugs, including:

• Corticosteroids: Increased risk of tendon rupture.

• NSAIDs: May increase risk of seizures.

• Warfarin: May enhance anticoagulant effect.

• Antacids / Iron / Zinc supplements: Reduce absorption — take 2 hours apart.

• Antidiabetic agents: Risk of hypo- or hyperglycemia.

• Antiarrhythmics / QT-prolonging drugs: Risk of cardiac arrhythmia.

• Multivalent cation IV solutions (Ca, Mg, Al): Incompatible with IV administration.

Warnings & Precautions

General Precautions

• Avoid unnecessary or repeated use to prevent antibiotic resistance.

• Use sunscreen and avoid prolonged sun exposure (photosensitivity risk).

• Maintain hydration during treatment to protect kidney function.

• Discontinue immediately if tendon pain or neuropathy occurs.

Population-Specific Warnings

• Pregnancy: Use only when absolutely necessary under medical supervision.

• Lactation: Not recommended; may affect infant joint development.

• Elderly: Higher risk of tendon rupture, arrhythmias, and renal complications.

• Renal Impairment: Dose adjustment required to prevent accumulation.Driving and Machinery Use

May cause blurred vision, dizziness, or confusion. Avoid driving or operating heavy machinery if affected.

Storage Conditions

• Store below 30°C in a dry, cool place.

• Protect from direct sunlight and moisture.

• Keep out of reach of children.

Pharmacological Notes

• Compatibility (IV Use): Stable in D5LR, D5NS, D5W, NS; incompatible with mannitol 20% and sodium bicarbonate 5%.

• IV Stability: Stable for 72 hours when diluted to 5 mg/mL at room temperature.

• Do not refreeze once thawed.

Quick Reference Table

Medical Disclaimer

This content is provided solely for educational and informational purposes on Cure Cart Direct.
It is not a medical prescription or professional treatment advice.