Description
Clarithromycin is a macrolide antibiotic used to treat a wide variety of bacterial infections. It works by stopping the growth of bacteria through inhibition of protein synthesis. It is also prescribed in combination with certain anti-ulcer medicines (such as proton pump inhibitors and amoxicillin) to treat Helicobacter pylori infections, which can cause stomach ulcers. This medicine is effective against respiratory tract infections, skin infections, and certain ear infections. It is important to note that clarithromycin treats bacterial infections only and has no effect on viral infections such as the common cold or flu.
Ingredients
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Clarithromycin (varies by strength: commonly 250mg, 500mg tablets, or oral suspension).
Drug Class
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Macrolide antibiotic.
Dosage Form
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Tablet
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Oral Suspension.
Uses
Clarithromycin is used for the treatment of:
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Respiratory tract infections (e.g., pneumonia, bronchitis, sinusitis, pharyngitis).
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Skin and soft tissue infections.
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Otitis media (middle ear infections).
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Helicobacter pylori-associated stomach ulcers (in combination therapy).
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Mycobacterial infections (in immunocompromised patients).
How To Use
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Take by mouth with or without food, as prescribed by your doctor.
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If stomach upset occurs, it may be taken with food or milk.
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For best results, take this antibiotic at evenly spaced intervals.
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Do not skip doses or stop early even if you feel better; stopping may allow bacteria to continue growing.
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Dosage and treatment duration depend on the infection being treated—consult your doctor for proper instructions.
Side Effects
Common side effects may include:
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Nausea, vomiting, stomach upset.
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Diarrhea.
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Altered taste sensation (metallic taste).
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Headache.
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Abdominal pain.
Serious but less common side effects:
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Severe allergic reactions (rash, itching, swelling, difficulty breathing).
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Liver problems (yellowing of skin/eyes, dark urine).
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Irregular heartbeat or chest pain.
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Severe diarrhea (may indicate Clostridium difficile infection).
Seek medical attention immediately if severe side effects occur.
Warnings & Precautions
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Do not use in patients allergic to clarithromycin, other macrolides (e.g., erythromycin, azithromycin), or any of its components.
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Use with caution in patients with liver or kidney disease.
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Clarithromycin may prolong the QT interval; avoid in patients with a history of cardiac arrhythmias.
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Avoid alcohol while using this medicine, as it may worsen side effects.
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Do not use for viral infections such as colds or flu.
Pregnancy & Lactation
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Use only if clearly needed and prescribed by a doctor.
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Clarithromycin may pass into breast milk; consult your doctor before use during breastfeeding.
Drug Interactions
Clarithromycin may interact with:
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Statins (e.g., simvastatin, lovastatin) → increased risk of muscle toxicity.
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Warfarin → increased risk of bleeding (monitor INR).
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Digoxin → increased digoxin levels.
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Other drugs that prolong QT interval (e.g., amiodarone, sotalol).
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Certain antifungal or antiviral drugs (e.g., ketoconazole, ritonavir).
Always inform your doctor about all medications you are taking.
Storage
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Store clarithromycin at room temperature, away from direct heat and sunlight.
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Keep out of reach of children and pets.
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Do not freeze oral suspension.
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Do not flush or throw away unused medication; consult your pharmacist for safe disposal.
Doctor’s Review
Clarithromycin remains an important option for treating bacterial respiratory and gastrointestinal infections, particularly in patients with H. pylori–related ulcers when combined with other therapies. It is generally well tolerated, but monitoring is necessary in patients with liver disease, kidney impairment, or those taking interacting medications. Completing the full course is crucial to avoid antibiotic resistance.
Disclaimer
The information provided here is for educational purposes only and is not a substitute for professional medical advice. Always consult your physician before starting, changing, or stopping any medication.

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