Lucrin

Description

Lucrin (Leuprorelin Acetate) is a GnRH analog that works by lowering certain hormone levels in the body. It acts on the pituitary gland to reduce the production of estrogen and testosterone. By suppressing these hormones, it helps manage hormone-dependent conditions, including specific types of cancers and reproductive health disorders.

Medical Uses

Doctors prescribe Lucrin 3.75mg injection for:

• Prostate cancer (advanced or hormone-dependent)

• Breast cancer (hormone-dependent, in premenopausal women)

• Endometriosis (relief of pelvic pain and control of disease progression)

• Uterine fibroids (to reduce symptoms such as heavy bleeding)

• Central precocious puberty (onset of puberty earlier than normal in children)

How It Works

Leuprorelin is a synthetic analog of gonadotropin-releasing hormone (GnRH). It initially causes a temporary rise in hormone levels (flare effect), followed by suppression of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This reduces estrogen in women and testosterone in men, slowing the growth of hormone-sensitive tissues and tumors.

Possible Side Effects

Some patients may experience:

• Hot flashes or sweating

• Headache, dizziness, or fatigue

• Joint or bone pain

• Mood changes (irritability, depression)

• Vaginal dryness (women) or erectile issues (men)

• Injection site pain or swelling

Serious but less common side effects:

• Bone density loss with long-term use

• Severe allergic reactions (rash, difficulty breathing, swelling)

• Worsening of symptoms in the first 1–2 weeks due to hormone flare

• Rare cardiovascular or liver complications

Seek immediate medical attention if you develop chest pain, difficulty breathing, severe bone pain, or neurological symptoms.

Warnings & Precautions

• Pregnancy: Contraindicated; may harm the fetus.

• Lactation: Not recommended during breastfeeding.

• Driving: May cause dizziness or fatigue; avoid driving until you know how it affects you.

• Alcohol: Should be avoided, as it may worsen side effects.

• Bone health: Long-term therapy may reduce bone density — calcium/vitamin D supplementation may be advised.

• Initial flare: Symptoms may temporarily worsen at the start of treatment; doctors may prescribe an anti-androgen to reduce this risk.

Contraindications

Do not use Lucrin if you:

• Are allergic to leuprorelin or any other GnRH analogs

• Are pregnant or breastfeeding

• Have undiagnosed abnormal vaginal bleeding

• Have severe osteoporosis (in certain cases, risk outweighs benefit)

Patient FAQs

How often is Lucrin 3.75mg given?
Usually every 4 weeks, but longer-acting formulations (3-month, 6-month) also exist.

Does Lucrin cure cancer?
No. It controls hormone levels and slows cancer progression but is not a cure.

Can it cause infertility?
Yes. Because it suppresses reproductive hormones, fertility may be affected. This is usually reversible after treatment ends.

Why do symptoms get worse at first?
This is called the flare effect, where hormone levels rise briefly before suppression begins. It usually improves within 1–2 weeks.

Do I need to stop if I feel better?
No. Always continue as directed by your doctor. Stopping early may cause the disease to progress.

Doctor’s Review

Dr. Imran Shah (MBBS, FCPS – Oncology, Lahore)

“Leuprorelin is an important therapy for hormone-sensitive cancers such as prostate and breast cancer. It can also be very effective in controlling gynecological conditions like endometriosis and fibroids. Patients should be informed about the initial flare reaction and the importance of completing the prescribed regimen. Long-term monitoring of bone health and regular follow-ups are essential for safe use.”

Storage

• Store in a refrigerator (2–8°C).

• Do not freeze.

• Protect from light.

• Keep out of reach of children.

Disclaimer

This description is for educational purposes only and not a substitute for medical advice. Lucrin should only be used under the supervision of a qualified doctor. Dosage, duration, and monitoring depend on individual medical conditions.