Maxflow-D

Description
Maxflow-D is a prescription medicine that combines Tamsulosin HCl (0.4mg) and Dutasteride (0.5mg). It is specially designed for men with benign prostatic hyperplasia (BPH) — a non-cancerous enlargement of the prostate gland. By relaxing prostate and bladder neck muscles and reducing the size of the prostate, Maxflow-D helps improve urine flow, relieves symptoms such as frequent or difficult urination, and lowers the risk of urinary retention or surgery.

How It Works

• Tamsulosin HCl blocks α1a and α1d adrenergic receptors in the prostate and bladder neck, relaxing muscles and improving urinary flow.

• Dutasteride inhibits 5-alpha-reductase (type 1 & 2), lowering dihydrotestosterone (DHT) levels — the hormone responsible for prostate growth. This reduces prostate size over time and prevents disease progression.

Usage and Safety

Dosage

• Take exactly as prescribed by the doctor.

• Usually once daily, swallowed whole with water after a meal.

• Do not chew or crush the capsule.

Side Effects

Common:

• Dizziness or lightheadedness

• Reduced sexual drive (libido)

• Ejaculation problems

• Impotence

• Breast tenderness or enlargement.

Uncommon:

• Cardiac failure (rare but possible in combination therapy)

Drug Interactions

• Strong CYP3A4 inhibitors: ketoconazole

• Moderate CYP3A4 inhibitors: erythromycin, terbinafine

• Strong CYP2D6 inhibitors: paroxetine

• Cimetidine: raises plasma tamsulosin levels

• PDE-5 inhibitors (e.g., sildenafil): may enhance low blood pressure risk

• Warfarin: requires INR monitoring

Indication

Maxflow-D is prescribed to:

• Treat and control benign prostatic hyperplasia (BPH)

• Reduce prostate volume

• Improve urinary flow rate

• Lower the risk of acute urinary retention (AUR)

• Decrease the need for BPH-related surgery

When Not to Use

Do not use if you are:

• Allergic to tamsulosin, dutasteride, soya, peanuts, or excipients

• A woman, child, or adolescent

• Diagnosed with severe liver impairment

• Having a history of orthostatic hypotension

Precautions

• Use only after proper risk–benefit assessment, especially in patients at risk of heart failure.

• Consider monotherapy in mild cases.

Warnings

1. Regular prostate cancer evaluation is required during therapy.

2. Use with caution in severe kidney impairment (CrCl <10 ml/min).

3. Patients should be warned about orthostatic hypotension symptoms (dizziness, fainting).

Pregnancy Category

• Not for use in women.

• Always consult a physician before starting treatment.

Storage

• Store at room temperature.

• Protect from heat, sunlight, and moisture.

• Keep out of reach of children.

Doctor’s Review

Dr. Ahsan Raza (MBBS, FCPS – Urologist)

Maxflow-D is highly effective in managing moderate to severe prostate enlargement. The combination provides both immediate relief of urinary symptoms and long-term reduction in prostate size. Patients must be regularly monitored for blood pressure changes and prostate health. Consistent follow-up with their urologist is essential for safe use.

Disclaimer

This content is for educational purposes only and should not replace medical consultation. Maxflow-D must be taken strictly under the prescription and supervision of a qualified doctor.