Merocin

Description

This is a potent broad-spectrum carbapenem antibiotic that fights bacterial infections by interfering with bacterial cell wall synthesis. It works by binding to and inhibiting specific penicillin-binding proteins (PBPs), which are essential for building bacterial cell walls. This causes the cell wall to weaken and rupture, killing the bacteria. Meropenem is particularly effective against a wide range of Gram-positive and Gram-negative bacteria, including those producing extended-spectrum beta-lactamases.

Formula

Each injection contains Meropenem 1000mg.

What It’s Used For

Pakistani doctors use this for:

• Severe bacterial infections caused by resistant organisms
• Abdominal, skin, and blood infections
• Hospital-acquired pneumonia
• Ventilator-associated pneumonia
• Broad range of gram-negative and gram-positive bacterial infections
• Last-resort treatment for severe, life-threatening infections
• Patients with impaired kidney function or on dialysis (with dose adjustment)

How to Use

• Must be administered by trained medical professionals under supervision.
• Reconstitute the powder with provided sterile water.
• Gently swirl to dissolve completely.
• Administer intramuscularly or intravenously as directed.
• Give slowly over the recommended time frame.
• Follow prescribed dosage and duration exactly.

Who Shouldn’t Use It

• Severe allergy to Meropenem or other carbapenem antibiotics
• History of severe allergic reactions to beta-lactam antibiotics (penicillins or cephalosporins)
• Severe kidney disease without proper dose adjustment
• History of seizures or conditions increasing seizure risk
• Known MRSA infection or organisms resistant to Meropenem
• Viral infections or non-bacterial infections
• History of Clostridioides difficile-associated diarrhea or colitis

Precautions

• Use with caution in patients with penicillin or cephalosporin allergy (potential cross-reactivity).
• Requires dose adjustments for kidney impairment.
• Prolonged use may cause superinfection, including C. difficile diarrhea.
• May cause seizures, especially in patients with neurological disorders or kidney problems.
• Monitor intravenous administration closely to avoid infusion reactions.
• Regular kidney and liver function tests needed during prolonged therapy.
• Elderly patients more susceptible to side effects.
• Don’t mix with other IV medications unless compatibility confirmed.
• Complete full course to prevent bacterial resistance.
• Inform doctor about any allergies or kidney/liver issues before starting.

Pregnancy and Breastfeeding

Consult your doctor before use during pregnancy or breastfeeding.

Possible Side Effects

Common:

• Nausea and vomiting
• Diarrhea
• Skin rashes or itching
• Headache
• Dizziness
• Injection site reactions (pain, swelling, redness)

Serious (rare):

• Seizures
• Allergic reactions (hives, difficulty breathing, swelling of face or throat)

Overdose Signs

Severe gastrointestinal symptoms (intense nausea, persistent vomiting, abdominal discomfort), neurological issues (dizziness, confusion, or seizures). Seek immediate medical help.

Missed Dose

Administer as soon as possible. If next dose is near, skip the missed one. Don’t double up. Contact healthcare provider if multiple doses missed.

Drug Interactions

• Probenecid: May increase Meropenem blood levels
• Valproic acid: Increases seizure risk
• Oral contraceptives: May reduce effectiveness—use alternative contraception
• Anticoagulants: Increases bleeding risk—requires close monitoring
• Mycophenolate mofetil: May decrease immunosuppressant concentration
• Live vaccines: Effectiveness may be reduced
• Vancomycin and other antibiotics: May increase antibiotic-associated colitis risk

Food Interactions

• Administer on empty stomach (1 hour before or 2 hours after meals)
• Avoid alcohol—increases side effects and reduces effectiveness
• Avoid grapefruit and grapefruit juice—interferes with metabolism
• Limit caffeine—may decrease effectiveness
• Maintain gap with dairy products, especially milk
• Avoid high-fat meals—delays absorption
• Avoid herbal supplements, particularly St. John’s Wort
• Consult healthcare provider for specific dietary recommendations

Storage

• Store at 68-77°F (20-25°C)
• Protect from light—keep in original packaging
• Keep container tightly sealed
• Don’t freeze
• Keep out of reach of children
• Dispose responsibly—consult pharmacist, don’t flush or pour down drain

Disclaimer: This information is for educational purposes only and is not a medical prescription. Always consult your doctor and discuss any queries related to this medicine, including possible precautions, side effects, contraindications, or drug interactions.