Description
Naproxen 500mg is a pain-relieving and anti-inflammatory medicine that belongs to the NSAID group. It works by blocking prostaglandins — natural substances that cause pain, swelling, and fever. By reducing these, Naproxen helps manage pain and inflammation in several conditions.
Uses
Doctors in Pakistan commonly prescribe Naproxen 500mg for:
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Acute pain (toothache, headache, post-surgery pain)
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Long-term management of arthritis, gout, and ankylosing spondylitis
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Menstrual cramps (dysmenorrhea)
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Muscle aches, strains, sprains, and back pain
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Fever and symptoms of cold or flu
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Pain after injury or minor surgery
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Migraine-related pain
Dosage
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Take as directed by your doctor.
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Usually once or twice daily, with food or milk.
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Swallow whole with a glass of water.
In Case of Overdose
Symptoms may include nausea, stomach pain, dizziness, ringing in the ears, or drowsiness. Severe cases can lead to rapid breathing or coma. Seek medical help immediately.
Missed Dose
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Take as soon as you remember.
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Skip if it’s almost time for your next dose.
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Do not double the dose.
When Not to Use
Avoid Naproxen if you have:
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Allergy to Naproxen, aspirin, or other NSAIDs
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Asthma attacks triggered by NSAIDs
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Stomach ulcers, bleeding, or gastrointestinal perforation
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Severe kidney, liver, or heart conditions
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Just had heart bypass surgery (CABG)
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Third trimester of pregnancy
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Rare blood disorders or porphyria
Side Effects
Possible side effects include:
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Stomach upset, nausea, or diarrhea
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Heartburn or indigestion
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Headache, dizziness, or lightheadedness
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Rash or itching
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Rise in blood pressure
Seek urgent medical care if you experience black stools, chest pain, severe stomach pain, or sudden vision changes.
Warnings & Precautions
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Use with caution in stomach ulcers, high blood pressure, kidney, liver, or heart problems.
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Long-term use may raise risk of heart attack or stroke.
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Elderly patients are more prone to stomach bleeding and kidney issues.
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Avoid alcohol while taking this medicine.
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Pregnant or breastfeeding women should use only on a doctor’s advice.
Drug Interactions
Naproxen may interact with:
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Other NSAIDs or aspirin
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Blood thinners (e.g., warfarin)
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Blood pressure medicines (ACE inhibitors, diuretics)
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Methotrexate or lithium
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Antidepressants (SSRIs)
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Antidiabetic drugs
Food Interactions
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Avoid alcohol (raises risk of stomach bleeding).
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Limit high-fat and high-salt foods.
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Take with food or milk to protect your stomach.
Storage & Disposal
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Store at room temperature in a cool, dry place.
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Keep tablets in original pack, tightly closed.
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Do not flush or pour into drains; follow proper disposal methods.
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Keep out of reach of children.
Quick Tips
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Always take Naproxen with food or milk.
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Do not exceed the prescribed dose.
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Inform your doctor of all medications you are using.
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Stop and seek medical advice if you notice unusual bleeding or allergic reactions.
Doctor’s Overview — Dr. Imran Siddiqui, MBBS, FCPS (Rheumatology, Karachi)
Naproxen is often used for arthritis, gout, and acute pain when longer-lasting relief is needed. It works well but should be taken with meals to reduce stomach irritation. Extra care is needed in older patients and in those with heart, kidney, or stomach problems. When monitored properly, it can significantly improve comfort and daily activity.
Disclaimer
This overview is for educational purposes only. Naproxen is a prescription medicine and should be used only under the guidance of a qualified healthcare professional.

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