Panaram

General Description

Paracetamol 120mg Syrup/Suspension is a widely used analgesic and antipyretic formulation designed for fever reduction and pain relief in children and adults. It works by acting on the central nervous system, where it inhibits prostaglandin synthesis through selective cyclooxygenase (COX-2) inhibition. This mechanism reduces pain perception and helps regulate body temperature. The syrup form ensures accurate dosing, better taste, and easier administration, particularly in pediatric patients.

Pharmacological Classification

• Generic Name: Paracetamol (Acetaminophen).

• Drug Class: Analgesic / Antipyretic.

• Therapeutic Category: Pain & Fever Management.

• Dosage Form: Syrup / Suspension.

• Strength: 120 mg per 5 mL.

• Prescription Required: No (OTC use under medical guidance recommended).

Composition

Each 5 mL contains:

• Paracetamol 120 mg.

Inactive ingredients include sorbitol, sucrose, flavoring agents, colorants, and purified water (may vary by manufacturer).

Mechanism of Action

Paracetamol primarily acts centrally by blocking cyclooxygenase (COX) enzymes in the brain and spinal cord.
This inhibition reduces the formation of prostaglandin E2 (PGE2), a compound responsible for pain transmission and fever regulation.
It also modulates serotonergic and noradrenergic pathways, contributing to its pain-relieving and temperature-lowering effects.
Unlike NSAIDs, Paracetamol has minimal anti-inflammatory activity, making it gentler on the stomach and suitable for children.

Pharmacokinetics

• Absorption: Rapid and complete from the gastrointestinal tract.

• Peak Concentration: Within 30 minutes to 2 hours.

• Metabolism: Extensively metabolized in the liver.

• Half-life: 2–4 hours.

• Excretion: Primarily through urine as conjugates.

Clinical Function / Uses

Paracetamol 120mg Syrup/Suspension is commonly used for:

• Reducing fever (pyrexia) in children and adults.

• Relieving mild to moderate pain such as headache, toothache, earache, and sore throat.

• Managing pain and fever after vaccinations.

• Providing comfort during teething or minor injuries in infants.

• Reducing muscle aches and cold-related discomfort.

• Used under medical advice for symptomatic relief in viral or bacterial infections.

Dosage

Use only as directed by a healthcare professional.
The dosage depends on the patient’s age, weight, and clinical condition.

• Children: Dose to be calculated per body weight (usually 10–15 mg/kg every 4–6 hours).

• Adults: As advised by a physician.

• Maximum Daily Dose: Do not exceed the total daily limit to prevent liver toxicity.

Always measure using the provided dosing cup or syringe to ensure accuracy.

In Case of Overdose

Overdose can lead to severe liver damage.
Early signs include nausea, vomiting, and abdominal pain, followed by elevated liver enzymes and jaundice. Immediate medical attention is essential. Treatment may require administration of acetylcysteine as an antidote under hospital supervision.

Missed Dose

If a dose is missed:

• Administer as soon as remembered.

• If it’s near the next scheduled dose, skip the missed one.

• Never double the dose to make up for a missed dose.
  Consistent dosing helps maintain therapeutic levels and ensures effective relief.

How to Use

1. Shake the bottle well before each use.

2. Use the provided measuring cup or dropper to ensure the correct dose.

3. Administer orally, with or without food.

4. Follow the dosing schedule prescribed by your healthcare provider.

When Not to Use

Do not use Paracetamol 120mg Syrup/Suspension in the following situations:

• Known allergy or hypersensitivity to paracetamol or any formulation component.

• Severe liver disease or acute liver failure.

• Kidney impairment or metabolic disorders affecting hepatic function.

• Chronic alcohol consumption or liver enzyme abnormalities.

• G6PD deficiency (rare hereditary condition).

Side Effects

Common Side Effects:

• Mild nausea or vomiting.

• Stomach discomfort.

• Increased sweating.

• Loss of appetite.

Rare but Serious Effects:

• Allergic skin reactions (rash, hives, swelling, difficulty breathing).

• Abnormal liver function or jaundice.

• Unusual bleeding or bruising.

• Persistent fatigue or dark-colored urine.

Seek prompt medical care if any severe reaction occurs.

Precautions & Warnings

• Do not exceed the recommended daily dose to prevent liver toxicity.

• Use with caution in patients with liver or kidney impairment.

• Avoid alcohol consumption during therapy.

• Do not use in infants under 3 months without medical consultation.

• Inform the physician about all concurrent medications.

• Stop use and seek medical advice if symptoms persist beyond 3 days (fever) or 5 days (pain).

Drug Interactions

Paracetamol may interact with:

• Warfarin and anticoagulants: May increase bleeding risk.

• Alcohol: Enhances hepatotoxicity.

• Anticonvulsants (e.g., carbamazepine, phenytoin): May affect liver metabolism.

• Other hepatotoxic drugs: Increases risk of liver injury.

• Opioids or sedatives: Additive CNS depressant effects.

• Anti-diabetic medications: Possible alteration of blood glucose control.

Food Interactions

• Alcohol: Strongly contraindicated due to liver toxicity risk.

• Grapefruit juice: May alter metabolism of Paracetamol.

• High-fat meals: Can delay absorption and onset.

• Caffeine: Large intake may reduce analgesic efficacy.
  Maintain a balanced diet and stay hydrated while on therapy.

Storage / Disposal

• Store at room temperature (below 30°C).

• Protect from light, heat, and moisture.

• Keep tightly sealed and out of children’s reach.

• Do not use if color changes or sediment forms.

• Dispose of unused or expired medicine safely through a pharmacist.

Control Drug

No

Quick Tips

• Always measure the dose precisely with the provided device.

• Administer after meals if mild stomach upset occurs.

• Ensure adequate fluid intake during fever.

• Do not mix with other medications containing Paracetamol.

• Consult a doctor if fever persists beyond 3 days.

Medical Disclaimer

The information above is intended solely for educational and informational purposes on Cure Cart Direct. It is not a substitute for professional medical advice or prescription.