Description Protium 40mg tablets, with pantoprazole sodium as the active ingredient, are proton pump inhibitors (PPIs) that reduce stomach acid production. By blocking acid-making enzymes in the stomach lining, they ease acid reflux, heal ulcers, and soothe esophageal inflammation. In Pakistan, doctors prescribe them for acid-related conditions, following Pakistan Medical Association guidelines, to relieve discomfort and prevent complications.
Ingredients Pantoprazole Sodium
Drug Class Proton Pump Inhibitor (PPI)
Dosage Form Tablet
Requires Prescription Yes
Uses In Pakistan, Protium 40mg is prescribed for:
- Acid reflux (heartburn, regurgitation) from gastroesophageal reflux disease (GERD).
- Healing and preventing duodenal and gastric ulcers.
- Moderate to severe reflux esophagitis (esophageal inflammation).
- Eradicating Helicobacter pylori (with two antibiotics) to reduce ulcer recurrence.
- Managing acid-related stomach discomfort, like burning or bloating.
- Preventing damage in chronic acid conditions.
Doctor’s Review Dr. Rabeya Tufail, MBBS from Ziauddin University and Managing Editor at CureCartDirect, states: “Protium 40mg tablets effectively cut stomach acid, helping with acid reflux, ulcers, and esophagitis. They’re key in H. pylori treatment plans and provide quick relief when used as directed.”
Dosage Take as prescribed by your doctor, typically one 40mg tablet daily, swallowed whole with water, preferably before a meal. For H. pylori eradication, it’s often combined with antibiotics for 7–14 days. Don’t exceed recommended doses without medical advice.
In Case of Overdose Overdose may cause nausea, dizziness, or confusion. If suspected, seek immediate medical help in Pakistan. Contact a doctor or poison control for guidance on managing symptoms, which may include monitoring or supportive care.
Missed Dose Take a missed dose as soon as remembered unless it’s nearly time for the next one—then skip it. Don’t double up to avoid side effects. Set reminders to stay on track.
How to Use Swallow the tablet whole with water, ideally before breakfast or as directed by your doctor. Don’t crush or chew.
When Not to Use Avoid Protium 40mg if you have:
- Allergy to pantoprazole or other PPIs.
- Hypersensitivity to any tablet ingredients.
Side Effects Possible side effects include:
- Uncommon: headache, dizziness, diarrhea, nausea, vomiting, bloating, constipation, dry mouth, abdominal pain, rash, itching, weakness, sleep issues, hip/wrist/spine fracture.
- Rare: taste changes, blurred vision, hives, joint/muscle pain, weight changes, fever, swelling in limbs, allergic reactions, depression, male breast enlargement.
- Very rare: disorientation. Report ongoing or severe effects to your doctor.
Precautions & Warnings Pakistan’s medical guidelines advise:
- Inform your doctor of liver problems—frequent enzyme checks may be needed, and treatment may stop if enzymes rise.
- Long-term use (over a year) may slightly raise fracture risk in hips, wrists, or spine.
- Report skin rashes, especially sun-exposed areas, or joint pain, as you may need to stop treatment.
- Use cautiously with a history of PPI-related skin reactions.
- Consult your doctor if pregnant, planning pregnancy, or breastfeeding—safety isn’t fully confirmed.
- Monitor for signs of low magnesium or vitamin B12 with prolonged use.
Drug Interactions Tell your doctor about all medications. Key interactions include:
- Antifungals (ketoconazole, itraconazole, posaconazole) or erlotinib (reduced absorption).
- Warfarin, phenprocoumon (increased bleeding risk).
- Atazanavir (reduced effectiveness).
- Methotrexate (increased levels, monitor closely).
- Fluvoxamine (may increase pantoprazole levels).
- Rifampicin (may reduce pantoprazole effects).
Food Interactions
- Take with or without food, but before meals is best for acid control.
- Avoid excessive alcohol, which may worsen acid reflux or stomach irritation.
- Limit spicy or acidic foods (e.g., citrus, tomatoes) if they trigger symptoms.
- Maintain a consistent diet to support steady absorption.
- Consult your doctor if on a low-sodium diet, as pantoprazole contains sodium.
Storage/Disposal Store at room temperature, away from direct light, heat, and moisture, in the original packaging, tightly sealed. Avoid bathrooms or kitchens. Dispose of expired or unused tablets per pharmacist or local waste guidelines to prevent environmental harm. Keep out of reach of children and pets.
Control Drug No
Quick Tips
- Take as prescribed, ideally before breakfast.
- Swallow whole, don’t crush or chew.
- Avoid alcohol and spicy foods if they worsen symptoms.
- Report rashes, joint pain, or persistent side effects.
- Inform your doctor of all meds to avoid interactions.
- Store in a cool, dry place, away from sunlight.
- Use for the shortest duration needed, especially long-term.
Disclaimer This is product information on Protium (pantoprazole sodium), not a medical prescription. Consult a qualified Pakistani doctor for diagnosis, treatment, or dosing. Do not self-medicate based on this content.

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