Risek 40mg

Risek Capsules 40mg contain Omeprazole, a proton pump inhibitor that irreversibly inhibits the H+/K+ ATPase enzyme system in gastric parietal cells, blocking the final step of acid production. This dose-dependent action suppresses both basal and stimulated gastric acid secretion, regardless of the stimulus, providing effective relief from acid-related disorders. It promotes esophageal healing, reduces symptom recurrence, and is a cornerstone in GERD management per ACG guidelines, with evidence supporting 4-8 week courses for erosive esophagitis.

Key Benefits:

• Rapid and sustained reduction in gastric acid secretion
• Heals erosive esophagitis and prevents relapse
• Alleviates heartburn and regurgitation in GERD
• Suitable for long-term maintenance in healed patients
• Broad applicability in acid-peptic disorders

How to Use

• Administration: Swallow capsule whole with a full glass of water.
• Timing: Once daily, preferably in the morning before a meal for optimal absorption.
• Dosage: 20-40mg daily for GERD; follow healthcare provider’s instructions (typically 4-8 weeks for initial treatment).
• Consistency: Take at the same time daily; do not crush or chew.
• Duration: Short-term for acute symptoms; extend for maintenance if needed.

Expert Tips from CureCart Direct:

• Take 30-60 minutes before breakfast to maximize acid suppression.
• Lifestyle aids: Elevate bed head, avoid late meals, limit triggers like caffeine/spicy foods.
• Monitor for B12 deficiency in long-term use (>1 year); annual checks advised.
• Do not use for immediate heartburn relief—antacids may complement.
• Consult for dose reduction in liver impairment.

Primary Uses

• Treatment of gastroesophageal reflux disease (GERD) symptoms.
• Healing and maintenance of erosive reflux esophagitis.
• Prevention of relapse in healed esophagitis patients.

Indications

Indicated in adults for:

• Erosive reflux esophagitis treatment (4-8 weeks; extend if needed).
• Long-term GERD management to prevent relapse.
• Symptomatic GERD relief. Per guidelines, effective in uncomplicated heartburn, peptic ulcers, and H. pylori eradication regimens (with antibiotics).

Side Effects

Common:

• Headache
• Gastrointestinal: Diarrhea, constipation, abdominal pain, nausea/vomiting, flatulence

Uncommon:

• Nervous system: Dizziness, paresthesia, somnolence, insomnia, vertigo
• Hepatic: Elevated liver enzymes
• Skin: Rash, pruritus, urticaria
• Other: Malaise

Rare:

• Nervous system: Reversible confusion, agitation, aggression, depression, hallucinations (mainly in severe illness)
• Endocrine: Gynecomastia

Long-term: Potential B12 malabsorption, increased fracture risk in elderly/high-dose use (>1 year).

Warnings and Precautions

• Pregnancy: Consult physician; generally Category C—use if benefits outweigh risks.
• Lactation: Limited data; consider alternatives or monitor infant.
• Driving: Generally safe; avoid if dizziness occurs.
• Liver Impairment: Reduce dose; bioavailability increases—monitor closely.
• Gastric Ulcer: Exclude malignancy before/during treatment; symptoms may mask.
• Fracture Risk: Modest increase in hip/wrist/spine fractures with high-dose/long-term use, especially in elderly or risk-factor patients.
• Vitamin B12: Risk of deficiency from reduced absorption in long-term therapy; screen at-risk patients.
• Other: Hypomagnesemia possible with prolonged use; monitor electrolytes.

Contraindications

Do not use in:

• Known hypersensitivity to Omeprazole, substituted benzimidazoles, or excipients.
• Concomitant use with nelfinavir.

Drug Interactions

• Antifungals: Ketoconazole, itraconazole, posaconazole—decreased absorption.
• Benzodiazepines: Diazepam—increased levels.
• Antidepressants: Citalopram, imipramine, clomipramine—increased exposure.
• Anticonvulsants: Phenytoin—increased levels.
• HIV Protease Inhibitors: Atazanavir, saquinavir—reduced efficacy.
• Cardiac Glycosides: Digoxin—increased levels.
• Antiplatelets: Clopidogrel—reduced activation.
• Tyrosine Kinase Inhibitors: Erlotinib—decreased efficacy.
• Immunosuppressants: Tacrolimus—increased levels.
• Antimetabolites: Methotrexate—increased toxicity.
• Antibiotics: Clarithromycin—increased Omeprazole levels.
• Inducers: Rifampicin, St. John’s Wort—CYP2C19/3A4 induction reduces efficacy.

Inform doctor of all medications.

Storage

Store at room temperature, away from direct light, heat, and moisture. Keep out of reach of children.

FAQs

How does Omeprazole work? Irreversibly blocks the proton pump (H+/K+ ATPase), inhibiting basal and stimulated acid secretion.

Best time to take? Morning before breakfast for optimal effect; consistent daily timing.

Long-term risks? B12 deficiency, fractures, infections (e.g., C. difficile); monitor with provider.

Safe in pregnancy? Consult doctor; use only if necessary.

Missed dose? Take ASAP unless near next—skip and resume; no doubling.

Duration for GERD? 4-8 weeks initial; maintenance as needed to prevent relapse.

Related Tests: Endoscopy for esophagitis, B12/electrolytes for long-term, H. pylori testing.

Doctor Review

Dr. Nadia Ahmed, MBBS, FCPS – Consultant Gastroenterologist “Omeprazole 40mg in Risek Capsules exemplifies PPI pharmacology by covalently binding the H+/K+ ATPase proton pump, achieving >90% acid suppression within 2-4 days and sustaining near-total inhibition with daily dosing. This facilitates mucosal healing in erosive esophagitis, with endoscopic resolution in 80-90% of GERD patients by 8 weeks per ACG guidelines. Pharmacokinetic considerations include CYP2C19 metabolism variability, influencing clearance in poor metabolizers, alongside enterohepatic recirculation extending half-life to 1-2 hours. Long-term use (>1 year) warrants surveillance for hypomagnesemia, fundic gland polyps, and fracture risk, particularly in elderly cohorts, while H. pylori co-therapy enhances ulcer eradication rates to >85% in quadruple regimens.”

Disclaimer: This information is for educational purposes only and not a substitute for professional medical advice. Always consult a qualified physician before use. CureCart Direct ensures accurate details but cannot cover all interactions or precautions. Prices and availability subject to change.