Sanid

Description

Flurbiprofen is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve pain, swelling, and stiffness caused by various conditions. It works by blocking cyclooxygenase (COX) enzymes, which produce prostaglandins — chemicals responsible for inflammation and pain. This makes it effective in treating arthritis, musculoskeletal disorders, dental pain, and headaches. As with other NSAIDs, it should be taken at the lowest effective dose for the shortest possible time to reduce risks such as stomach irritation and cardiovascular problems.

Ingredients

• Flurbiprofen 100mg.

Drug Class

• Nonsteroidal Anti-Inflammatory Drug (NSAID).

Uses

• Pain and inflammation in osteoarthritis and rheumatoid arthritis.

• Acute pain (dental, post-surgical, or musculoskeletal).

• Pain from sprains, strains, and soft tissue injuries.

• Relief of tendinitis and bursitis symptoms.

• Headaches, tension headaches, and migraines.

• Gout flare-ups (short-term use).

• Dysmenorrhea (painful menstruation).

• Fever reduction in inflammatory conditions.

Dosage

• Adults (general pain/inflammation): 100–200mg per day, divided into 2–3 doses.

• Arthritis (RA or OA): 200–300mg per day, divided into doses.

• Acute pain (dental, surgical, musculoskeletal): 100mg single dose, with repeat if needed.

• Headache/migraine: 100–200mg daily in divided doses.

• Gout or dysmenorrhea: usually 100–200mg daily, adjusted for severity.

• Missed dose: take when remembered; skip if close to next scheduled dose. Do not double.

• Overdose: may cause nausea, vomiting, dizziness, stomach pain, or bleeding. Seek emergency help immediately.

Side Effects

• Nausea, vomiting, diarrhea, constipation.

• Headache, dizziness, tinnitus (ringing in ears).

• Fatigue, rash, swelling (edema).

• Stomach pain or discomfort.

• Ulcers, bleeding, or perforation (with prolonged use).

Precautions & Warnings

• Use with caution in patients with stomach ulcers, Crohn’s disease, or colitis.

• May increase risk of heart attack, stroke, or high blood pressure with long-term use.

• Can worsen kidney or liver function — dose adjustments may be needed.

• Prolonged use raises risk of gastrointestinal bleeding and ulceration.

• May cause fluid retention and worsen heart failure in susceptible patients.

• Patients with asthma may have NSAID-triggered respiratory issues.

• Avoid alcohol — increases stomach bleeding risk.

• Not recommended in the last trimester of pregnancy.

• May cause dizziness or drowsiness — avoid driving if affected.

Contraindications

Do not use if:

• Allergy to flurbiprofen, aspirin, or other NSAIDs.

• History of severe peptic ulcers or gastrointestinal bleeding.

• Severe heart failure.

• Severe liver or kidney impairment.

• Blood clotting disorders.

• Third trimester of pregnancy.

• Children under 12 years unless advised by a doctor.

• Concurrent use of other NSAIDs or anticoagulants.

Drug Interactions

• Anticoagulants (warfarin, clopidogrel, dabigatran): ↑ bleeding risk.

• Other NSAIDs (aspirin, ibuprofen): ↑ GI side effects.

• ACE inhibitors, ARBs, diuretics: ↓ effectiveness, ↑ kidney risk.

• Lithium: ↑ lithium levels, risk of toxicity.

• Corticosteroids: ↑ ulcer and GI bleeding risk.

• Methotrexate: ↑ risk of toxicity.

• SSRIs (fluoxetine, sertraline): ↑ GI bleeding risk.

• Cyclosporine: ↑ kidney damage risk.

• Beta-blockers/antihypertensives: reduced effectiveness.

Food Interactions

• Take with food or milk to reduce stomach irritation.

• Avoid alcohol — raises bleeding and liver risks.

• Limit potassium-rich foods if using long-term (may affect kidney balance).

• High-fat meals may delay absorption slightly.

• Avoid grapefruit juice if possible (interaction risk uncertain).

Storage

• Store at 15–30°C, away from sunlight and moisture.

• Keep in original packaging.

• Out of reach of children and pets.

• Do not store in bathroom or humid areas.

• Dispose of expired or unused tablets safely — not in toilets or drains.

Quick Tips

• Take with food to minimize stomach upset.

• Use the lowest effective dose for the shortest time.

• Monitor blood pressure if using long-term.

• Stay hydrated to protect kidneys.

• Avoid alcohol and limit caffeine.

• Contact your doctor if stomach pain, bleeding, or unusual bruising occurs.

Laboratory Screening

• Kidney tests: serum creatinine, BUN (especially with long-term use).

• Liver function tests: ALT, AST, bilirubin (if liver issues suspected).

• Blood pressure monitoring: for patients with hypertension.

• CBC: to detect GI bleeding or blood changes.

• Electrolytes: especially potassium, if used long-term.

• Heart function: periodic check for patients with cardiovascular history.

Doctor’s Review

Dr. Sameer Malik – Consultant Rheumatologist
“Flurbiprofen is a traditional NSAID commonly used to manage arthritis-related pain and inflammation, as well as acute musculoskeletal pain. It is effective, but like all NSAIDs, it carries risks such as stomach irritation, bleeding, and cardiovascular effects. Careful use at the lowest effective dose and for the shortest necessary duration is key to balancing benefit with safety.”

Disclaimer

This profile is intended for educational purposes only. It is not medical advice. Always consult a qualified healthcare professional before starting or stopping any medication.