Valcard 5/80mg

Description Amlodipine/Valsartan Tablets combine Amlodipine (5mg), a calcium channel blocker, and Valsartan (80mg), an angiotensin II receptor blocker (ARB), to manage hypertension and related cardiovascular conditions. Amlodipine relaxes blood vessels by inhibiting calcium influx into vascular smooth muscle, increasing blood and oxygen flow to the heart while reducing its workload. Valsartan blocks angiotensin II receptors, preventing vasoconstriction and aldosterone release, further lowering blood pressure. This synergistic combination is ideal for adults needing effective blood pressure control or cardiovascular risk reduction, often used when monotherapy is insufficient.

Ingredients Amlodipine 5mg, Valsartan 80mg.

Drug Class Calcium Channel Blocker and Angiotensin II Receptor Blocker / Antihypertensive Combination.

Dosage Form Tablet (Pack size not specified; typically 10 or 30 tablets per strip).

Uses Amlodipine/Valsartan Tablets are prescribed for:

• Managing hypertension (high blood pressure).
• Reducing risk of cardiovascular events (e.g., heart attack, stroke).
• Improving overall cardiovascular health.
• Supporting blood pressure control in resistant cases.
• Enhancing kidney function in hypertensive patients.
• Alleviating heart failure symptoms.
• Reducing left ventricular hypertrophy.

Doctor’s Review Dr. Nida Aslam, a prominent cardiologist in Lahore, recommends this combination for its comprehensive approach: “Amlodipine and Valsartan together offer robust blood pressure control by targeting different pathways, making it ideal for patients with hypertension or heart failure. It’s well-tolerated, but I always monitor for swelling or electrolyte imbalances to ensure safe, effective therapy.”

Dosage (Follow physician’s instructions — typical guideline)

• Adults: 1 tablet (5mg Amlodipine/80mg Valsartan) once daily; may increase to 5mg/160mg or 10mg/160mg after 1-2 weeks if needed.
• Maximum: 10mg Amlodipine/320mg Valsartan daily.
• Elderly or mild renal/hepatic impairment: Start with 5mg/80mg; adjust cautiously.
• Not for children; avoid in severe renal (GFR <30ml/min) or hepatic impairment.
• Take consistently, with or without food.

In Case of Overdose Overdose may cause chest discomfort, clammy skin, weak pulse, flushing, fainting, or slow heartbeat. Seek immediate medical attention. Treatment includes supportive care (e.g., IV fluids, vasopressors for hypotension); monitor heart rate and electrolytes. Dialysis is ineffective for Valsartan removal but may help with Amlodipine.

Missed Dose Take as soon as remembered unless close to the next dose. Skip the missed dose if near the next scheduled time—do not double up to avoid hypotension or dizziness. Resume your regular schedule and consult your doctor if misses are frequent.

How to Use

• Swallow tablet whole with a full glass of water, with or after meals to reduce stomach upset, or on an empty stomach if tolerated.
• Take at the same time daily (e.g., morning) for steady effects.
• Do not crush, chew, or split the tablet to maintain proper release.
• Monitor blood pressure regularly with a home device.
• Pair with a low-sodium diet and exercise as advised.

When Not to Use Avoid Amlodipine/Valsartan if:

• Pregnant (especially second/third trimesters—fetal harm).
• Allergic to Amlodipine, Valsartan, or excipients.
• Using aliskiren in diabetic patients (risk of hyperkalemia).
• Severe hepatic impairment or biliary obstruction.
• Severe renal impairment (GFR <30ml/min).
• History of angioedema with ARBs or ACE inhibitors.

Side Effects Common:

• Swelling in feet/hands (edema).
• Spinning sensation (vertigo), dizziness.
• Cold/flu-like symptoms (nasal congestion, sore throat).

Uncommon / Severe (Stop and seek medical help):

• High blood potassium (arrhythmia, muscle weakness).
• Liver dysfunction (yellowing skin, dark urine).
• Heart problems (chest pain, irregular heartbeat).
• Severe allergic reactions (rash, swelling, breathing difficulty).

Precautions & Warnings

• Inform your doctor of liver/kidney disease, recent heart attack, or angioedema history.
• Monitor for swelling or breathing issues, especially in ARB-related angioedema cases.
• Use cautiously in patients with vomiting/diarrhea—risk of dehydration and hypotension.
• Check potassium and kidney function regularly, especially with diuretics or diabetes.
• Avoid in breastfeeding unless benefits outweigh risks—consult your doctor.
• May cause dizziness—avoid driving or machinery until adjusted.

Drug Interactions

• Cyclosporine: Increases Amlodipine levels; monitor for toxicity.
• Sildenafil: Enhances hypotensive effects—watch for low BP.
• Rifampin: Reduces Amlodipine/Valsartan efficacy.
• Ritonavir: Increases Amlodipine levels; adjust dose if needed.
• Diuretics: Heightens hypotension or hyperkalemia risk.
• Herbal formulations (e.g., St. John’s Wort): May reduce efficacy.
• Aliskiren in diabetics: Avoid due to renal/hyperkalemia risks.

Food Interactions

• Can take with or without meals; food may reduce dizziness.
• Limit salt intake to enhance BP control.
• Avoid grapefruit juice—may increase Amlodipine levels.
• Moderate potassium-rich foods (e.g., bananas) to prevent hyperkalemia.
• Limit alcohol to avoid worsening hypotension or dizziness.
• Stay hydrated to support kidney function and BP stability.

Storage/Disposal

• Store at room temperature (15-30°C), in a cool, dry place away from direct sunlight and moisture.
• Keep in original packaging, out of reach of children and pets.
• Do not use past expiration date; check package for details.
• Dispose via pharmacy take-back programs; do not flush or trash to prevent misuse.

Quick Tips

• Take with food to minimize dizziness or stomach upset.
• Monitor BP weekly and share readings with your doctor.
• Report swelling, irregular heartbeat, or fainting immediately.
• Follow a low-salt, heart-healthy diet for better results.
• Avoid sudden standing to prevent lightheadedness.
• Do not crush, chew, or split the tablet.

Disclaimer This information is provided for educational purposes only and does not replace medical advice. Use only under the supervision of a licensed physician. Do not self-medicate.