Xepex

Description

Ziprasidone acts by blocking dopamine (D2) and serotonin (5-HT2A, 5-HT1A) receptors in the brain. This dual action controls hallucinations, delusions, mood instability, and agitation, making it effective for schizophrenia and bipolar disorder. Its receptor selectivity may result in lower risk of movement-related side effects compared to older antipsychotics.

Uses

• Management of Schizophrenia.

• Treatment of Bipolar Mania or Mixed Episodes.

• Reduction of hallucinations & delusions.

• Control of anxiety, restlessness, and aggression.

• Improvement of clarity of thought and behavior regulation.

How to Use

Swallow one capsule with a full glass of water, usually twice daily (morning & evening) as directed. Do not crush or chew.

When Not to Use

Avoid use in:

• Allergy to Ziprasidone or similar antipsychotics.

• Heart rhythm disorders / Prolonged QT interval.

• Severe heart disease or stroke history.

• Elderly patients with dementia.

• Severe liver disease or uncontrolled seizures.

• Breastfeeding mothers.

Side Effects

• Dizziness, headache.

• Nausea, diarrhea or constipation.

• Drowsiness or fatigue.

• Muscle stiffness or tremors.

• Restlessness (akathisia).

Precautions & Warnings

• May prolong QT interval — ECG monitoring recommended in cardiac patients.

• Do not stop abruptly — risk of withdrawal agitation.

• Avoid alcohol — increases sedation.

• Monitor blood sugar in diabetic patients.

Drug Interactions

Use cautiously with:

• Other antipsychotics or CNS depressants (↑ sedation).

• Antiarrhythmics / Antidepressants that prolong QT.

• Anticonvulsants (may reduce effectiveness).

• Blood pressure medications (risk of hypotension).

• Warfarin, antifungals, antibiotics (require monitoring).

Food Interactions

• Avoid grapefruit juice.

• Do not consume with alcohol.

• High-fat meals may reduce absorption.

Storage

Store at room temperature, in original packaging, tightly sealed. Keep away from children and moisture.

Doctor’s Review

Dr. Sarah Malik, Consultant Psychiatrist:
“Ziprasidone is a valuable option for patients needing mood stabilization without excessive weight gain or sedation. I often prefer it for individuals struggling with both psychotic symptoms and agitation. Consistent dosing and ECG monitoring are essential for safety.”

Disclaimer

This profile is for information only and not a substitute for professional medical advice. Always consult your psychiatrist or healthcare provider before starting or adjusting any medication.