Ziclopel

Ziclopel (50mg) – 20 Capsules

Manufacturer: Z-Jans Pharmaceutical (Pvt.) Ltd.
Generic Name: Diclofenac Potassium 50mg

Ziclopel contains diclofenac, a non-steroidal anti-inflammatory drug (NSAID) used to treat pain and inflammation. Diclofenac works by inhibiting cyclooxygenase-1 and -2 (COX-1 and COX-2), enzymes responsible for producing prostaglandins that cause pain and inflammation. By blocking these enzymes, diclofenac reduces pain, swelling, and inflammation effectively.

Ingredients

• Diclofenac Potassium 50mg

Uses

Diclofenac potassium is used for:

• Management of pain and inflammation

• Osteoarthritis treatment

• Relief of symptoms in rheumatoid arthritis

• Acute gout attacks

Dosage

Dosage should always follow your doctor’s instructions. General guidance:

• Immediate-release tablets: 50mg every 8–12 hours

• Recommended adult dose: 75–150mg daily in 2–3 divided doses

• Maximum daily dose: 150mg

• Specific conditions:

  • Osteoarthritis/Rheumatoid arthritis: 50mg every 8 hours

  • Menstrual cramps: 50mg 3 times a day

  • Migraine: 50mg as a single dose in 30–60 mL water

  • Ankylosing spondylitis: 50mg every 12 hours

• Children (≥3 years, Juvenile Idiopathic Arthritis): 2–3 mg/kg/day, up to 4 weeks

In case of Overdose

Seek immediate medical attention. Overdose may cause: headache, nausea, vomiting, GI bleeding, dizziness, disorientation, convulsions, renal failure, liver damage, and more. Management involves supportive and symptomatic treatment, gastric decontamination, and activated charcoal if necessary.

Missed Dose

Take the next dose as soon as you remember. Do not double the dose to compensate.

How to Use

Take with food to reduce the risk of gastrointestinal bleeding.

When Not to Use

Avoid diclofenac if you have:

• Hypersensitivity to the drug or excipients

• Gastric or intestinal ulcer, bleeding, or perforation

• History of NSAID-related GI complications

• Severe liver, kidney, or heart failure

• Aspirin triad (asthma, nasal polyps, and aspirin sensitivity)

Side Effects

Common side effects may include:

• Headache, dizziness, vertigo

• Nausea, vomiting, diarrhea, dyspepsia, abdominal pain, flatulence, anorexia

• Rash, urticaria, edema

• Elevated liver enzymes, liver disorder, hepatitis, jaundice

• Hypersensitivity reactions (including anaphylaxis)

• Gastrointestinal bleeding or ulceration (may be fatal in elderly)

• Somnolence, tiredness, asthma, gastritis

Precautions & Warnings

• Ulceration and bleeding may occur even without prior GI symptoms

• Use the lowest effective dose for the shortest duration

• Discontinue if liver disease signs appear (e.g., jaundice, rash)

• Can cross the placenta; may cause birth defects or miscarriage

• Monitor use carefully in elderly and high-risk patients

Food Interactions

• Avoid tobacco, coffee, and spicy food while using diclofenac

• Take with milk and food to reduce GI bleeding risk

Storage/Disposal

Store at 25°C. Protect from sunlight and moisture.

Laboratory Screening

For severe bone pain or to check for rheumatoid arthritis: RA Factor Test may be recommended.

Doctor’s Review

Reviewed by: Dr. [Full Name], MD/Pharmacist

“Ziclopel (diclofenac potassium) is an effective NSAID for managing pain and inflammation. It is useful in arthritis, gout attacks, and other inflammatory conditions. Patients should take the lowest effective dose for the shortest duration and monitor for gastrointestinal and liver-related side effects. Regular medical follow-up is advised.”

Disclaimer

The information provided is for educational purposes only and does not replace professional medical advice. Consult your healthcare provider before using Ziclopel, especially if you have liver, kidney, heart conditions, are pregnant, or breastfeeding. Side effects may vary individually.