Zotrium

Zotrim Product Profile

Description

Zotrim is a combination antibiotic medication that includes Sulfamethoxazole and Trimethoprim, commonly known as co-trimoxazole. This combination works synergistically to inhibit bacterial folic acid synthesis, thereby preventing bacterial growth and replication. Zotrim is primarily used to treat various bacterial infections.

Ingredients

• Sulfamethoxazole: An antibiotic that inhibits bacterial folic acid synthesis.

• Trimethoprim: An antibiotic that inhibits a subsequent step in the bacterial folic acid pathway.

Drug Class

Antibiotic (Sulfonamide and Folate Synthesis Inhibitor Combination)

Dosage Form

• Tablets: Commonly available in 400mg/80mg strengths.

• Suspension: Available for pediatric use.

Uses

Zotrim is indicated for the treatment of various bacterial infections, including:

• Urinary Tract Infections (UTIs)

• Respiratory Tract Infections (e.g., bronchitis, pneumonia)

• Ear Infections (Otitis Media)

• Gastrointestinal Infections (e.g., enteritis)

• Traveler’s Diarrhea

• Skin and Soft Tissue Infections

• Pneumocystis Pneumonia (PCP)

• Toxoplasmosis

Dosage

• Adults: One double-strength tablet (160mg Trimethoprim / 800mg Sulfamethoxazole) every 12 hours for 10 days.

• Pediatric Dosage: 1ml/kg body weight in two divided doses daily for 10 days (for children ≥2 months).

In Case of Overdose

Overdose may lead to symptoms such as nausea, vomiting, and dizziness. Seek immediate medical attention if overdose is suspected.

Missed Dose

If a dose is missed, take it as soon as remembered. If it’s almost time for the next dose, skip the missed dose. Do not double the dose to make up for a missed one.

How to Use

Swallow the tablet whole with a full glass of water. It can be taken with or without food.

When Not to Use

Contraindications include:

• Known allergy to sulfonamides or trimethoprim.

• Severe liver or kidney impairment.

• Infants under 2 months of age.

• History of drug-induced immune thrombocytopenia or megaloblastic anemia due to folate deficiency.

Side Effects

Common side effects may include:

• Nausea and vomiting

• Skin rash

• Loss of appetite

• Headache

• Dizziness

• Elevated potassium levels

Precautions & Warnings

• Use with caution in patients with liver or kidney disease.

• Monitor blood counts during prolonged therapy.

• Avoid excessive sun exposure due to increased sensitivity.

• Discontinue use if a severe allergic reaction occurs.

Drug Interactions

Zotrim may interact with:

• Anticoagulants (e.g., warfarin)

• Certain diuretics

• Phenytoin

• Methotrexate

• Other folate antagonists

Food Interactions

• Avoid alcohol consumption as it may increase the risk of side effects.

• No significant food interactions noted; however, it’s advisable to take the medication with food to reduce gastrointestinal discomfort.

Storage/Disposal

• Store at room temperature, away from moisture and heat.

• Keep out of reach of children.

• Dispose of unused medication properly, following local guidelines.

Quick Tips

• Complete the full course of therapy, even if symptoms improve, to prevent resistance.

• Stay hydrated during treatment.

• Regular follow-up appointments may be necessary to monitor for side effects.

Laboratory Screening

Regular blood tests may be required to monitor for potential side effects, especially during prolonged use.