Zurig

Febuxostat lowers uric acid in the blood by blocking an enzyme called xanthine oxidase. This helps prevent gout attacks, kidney stones, and complications linked to uric acid buildup. It is often prescribed to patients who cannot use allopurinol or did not respond well to it.

Uses

• Treatment of gout

• Management of high uric acid (hyperuricemia)

• Prevention of urate crystals, tophi, and kidney stones

Dosage & Administration

• Usual adult dose: 80mg once daily

• In some cases, dose may be increased to 120mg once daily (doctor’s advice only)

• Can be taken with or without food, preferably at the same time each day

Missed Dose / Overdose

• Missed dose: Take it when you remember, or skip if it’s nearly time for your next dose. Do not double up.

• Overdose: May cause abdominal pain, nausea, or serious side effects. Seek emergency medical help immediately.

When Not to Use

Avoid if you have:

• Severe liver disease

• Allergy to Febuxostat

• Heart problems (recent heart attack, unstable angina) without clearance from your doctor

• An active gout flare, unless your doctor instructs otherwise

Side Effects

• Headache, nausea, diarrhea

• Rash, joint pain, tiredness

• Temporary increase in liver enzymes

• Gout flares at the start of treatment

• Rare: Heart-related complications

Warnings & Precautions

• Regular monitoring of liver function and uric acid is important

• Use with caution in kidney or heart disease

• Avoid alcohol and high-purine foods (red meat, shellfish, beer)

• Not recommended during pregnancy or breastfeeding unless prescribed

Drug & Food Interactions

• Do not use with azathioprine or mercaptopurine (severe toxicity risk)

• Can interact with warfarin – INR should be monitored

• Grapefruit juice and excess alcohol may worsen side effects

• Stay well-hydrated to protect kidney function

Storage

Store at room temperature, away from moisture, sunlight, and heat. Keep out of children’s reach.

Quick Advice

• Take daily at the same time for best results

• Drink plenty of water

• Avoid alcohol and foods rich in purines

• Report unusual symptoms such as rash or chest pain to your doctor immediately

Doctor’s Opinion

“Febuxostat is an effective option for managing gout, particularly in patients who cannot take allopurinol. It works well to lower uric acid but should be prescribed carefully in people with heart or liver issues.”
— Dr. Sara Khan, Consultant Rheumatologist

Disclaimer

This information is provided for educational purposes only. Febuxostat should only be used under the guidance of a licensed healthcare professional. Do not adjust your dose or stop treatment without medical advice.