Sulforin

Description

Sulforin 160mg/800mg Tablet is a broad-spectrum antibacterial medicine that combines two active ingredients — Trimethoprim and Sulfamethoxazole. Together, they act synergistically to block two consecutive steps in the bacterial synthesis of folic acid, a nutrient essential for bacterial growth and replication. This dual mechanism makes Sulforin highly effective against a wide range of bacterial infections, including those resistant to single-drug therapy.

It is primarily prescribed for urinary tract infections (UTIs), respiratory tract infections, skin infections, and certain gastrointestinal infections caused by susceptible bacteria.

Primary Uses

• Treatment of bacterial infections.

• Urinary tract infections (UTIs).

• Respiratory tract infections (e.g., bronchitis, pneumonia).

• Gastrointestinal infections (e.g., traveler’s diarrhea, typhoid).

• Skin and soft tissue infections.

• Ear, nose, and throat infections.

How It Works

Sulforin works by combining the antibacterial actions of its two components:

• Sulfamethoxazole inhibits the first step in the bacterial folic acid synthesis pathway.

• Trimethoprim blocks the next step in this pathway.
  By inhibiting two different enzymes required for folic acid production, the combination effectively halts bacterial DNA synthesis, resulting in the death of the bacterial cells.

This synergistic mechanism makes Sulforin more potent and effective than either drug alone.

Dosage and Administration

• The dosage depends on the type and severity of infection, age, and kidney function.

• Usually taken orally twice a day with a full glass of water.

• Always complete the full course as prescribed, even if symptoms improve earlier.

• Do not skip or double doses.

• Drink plenty of fluids to prevent kidney stones or crystalluria.

Side Effects

Common Side Effects:

• Nausea or vomiting

• Loss of appetite

• Mild rash or itching

• Glossitis (swelling of the tongue)

Serious Side Effects (Seek medical help immediately):

• Severe skin reactions (redness, blistering)

• Yellowing of eyes or skin (liver dysfunction)

• Difficulty breathing or swelling of the face

• Persistent sore throat or fever (possible blood disorders)

• Severe diarrhea or abdominal pain

Warnings and Precautions

• Hydration: Drink plenty of water during treatment to prevent kidney-related side effects.

• Kidney or Liver Disease: Use with caution in patients with renal or hepatic impairment.

• Elderly Patients: Increased risk of side effects; close monitoring advised.

• Allergies/Asthma: Use carefully if you have a history of severe allergies or asthma.

• Sun Sensitivity: May increase sensitivity to sunlight; avoid prolonged sun exposure.

Pregnancy and Lactation

• Pregnancy: Not recommended during pregnancy as it may harm the unborn baby.

• Lactation: Should not be used during breastfeeding; small amounts can pass into breast milk and affect the infant.

Contraindications

Sulforin should not be used in:

• Newborns (below 2 months of age)

• Patients with severe kidney or liver disease

• Allergy to sulfonamides, trimethoprim, or any tablet components

• Patients with folate deficiency anemia or porphyria

• Pregnant or breastfeeding women (unless prescribed by a doctor)

Drug Interactions

Avoid combining with:

• Warfarin (may increase bleeding risk)

• Methotrexate (increased toxicity)

• Phenytoin (increased levels leading to toxicity)

• Cyclosporine (increased kidney damage risk)

• Oral hypoglycemics (may increase hypoglycemia risk)

• Diuretics (increased risk of thrombocytopenia)

Always inform your doctor about all the medicines and supplements you are taking.

Storage Instructions

• Store at room temperature (below 25°C).

• Keep away from moisture, direct sunlight, and heat.

• Do not store in the bathroom.

• Keep out of reach of children and pets.

Quick Tips

• Take the medicine after meals with plenty of water.

• Avoid alcohol and excessive sunlight exposure.

• Do not stop early — complete the full course even if you feel better.

• Report any rash, fever, or yellowing of skin immediately.

• Maintain good hydration throughout the treatment.

FAQs

1. How long does it take to work?
It begins to act shortly after ingestion, but noticeable improvement may take 2–3 days.

2. Can I stop taking Sulforin once I feel better?
No. Complete the prescribed course to prevent bacterial resistance and recurrence of infection.

3. Is it safe for children?
Not for children under 2 months. For older children, dosage should be adjusted by a doctor.

4. What should I do if I develop itching or rash?
Stop the medicine immediately and consult your doctor for an alternative antibiotic.

5. What precautions should I follow?
Stay hydrated, avoid prolonged sunlight, and do not skip doses.

Disclaimer:
This information is for educational purposes only and should not replace medical advice. Always consult a qualified healthcare professional before using Sulforin or any other medication.