Amis 100 MG: Uses, Dosage, Side Effects & More

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March 6, 2026

On March 6, 2026

Manufacturer: D.D Pharmaceuticals Salt/Composition: Amisulpride 100 MG Medicine Type: Antipsychotic (Atypical) Prescription Required: Yes

What is Amis 100 MG Tablet?

Amis 100 MG Tablet contains Amisulpride as its active ingredient. It belongs to the atypical antipsychotic class of medicines and is mainly prescribed to treat schizophrenia in adults. It works by blocking dopamine receptors in the brain, helping to reduce hallucinations, delusions, and disordered thinking.

This is a prescription-only medicine. Always take it under the supervision of a qualified psychiatrist.

Uses of Amis 100 MG Tablet

Amis 100 MG is prescribed for:

Schizophrenia – A chronic mental disorder causing hallucinations, delusions, and disturbed thinking
Acute Psychosis – A sudden and severe episode of mental disturbance with loss of reality
Negative Symptoms of Schizophrenia – Such as emotional flatness, reduced motivation, and social withdrawal

How Does Amis 100 MG Work?

Amis 100 MG blocks dopamine D2 and D3 receptors in the brain. In schizophrenia, dopamine becomes overactive, leading to hallucinations and delusions. By controlling this excess activity, the medicine helps:

Reduce positive symptoms like hallucinations and delusions
Improve negative symptoms like emotional flatness at lower doses
Stabilize mood and behavior gradually over time

Dosage of Amis 100 MG Tablet

Your doctor will decide the right dose based on your age, condition, and treatment response. Below is a general dosage guide:

Condition	Recommended Dose
Acute Schizophrenia	400–800 mg/day
Severe Acute Episodes	Up to 1200 mg/day (maximum)
Negative Symptoms	50–300 mg/day
Maintenance Dose	Minimum effective dose (individually set)

Key dosage rules:

Doses up to 300 mg — take once daily at the same time
Doses above 300 mg — split into two (morning and evening)
Can be taken with or without food

How to Take Amis 100 MG Tablet

Taking this medicine correctly is important for the best results:

Swallow the tablet whole — do not crush, chew, or break it
Take it at the same time every day without fail
Do not stop suddenly — always taper off under your doctor’s guidance
Complete the full prescribed course, even if you feel better early

Missed Dose

If you miss a dose, take it as soon as you remember. If it is nearly time for your next dose, simply skip the missed one. Never double up on doses to compensate for a missed one.

Overdose — What to Do?

An overdose requires immediate emergency medical attention. Watch for these warning signs:

Excessive drowsiness or sedation
Sudden drop in blood pressure
Severe muscle stiffness or twitching
Irregular or rapid heartbeat
Severe agitation or confusion
Loss of consciousness or coma

If any of these occur, call emergency services or go to the nearest hospital immediately. Do not attempt to manage an overdose at home.

Side Effects of Amis 100 MG Tablet

Not everyone experiences side effects, and many reduce as the body adjusts. Here is a clear breakdown:

Common Side Effects:

Nausea or vomiting
Dry mouth
Constipation
Dizziness or drowsiness
Restlessness or agitation
Insomnia (trouble sleeping)
Weight gain
Blurred vision

Less Common Side Effects:

Erectile dysfunction or decreased libido
Trembling or muscle stiffness
Restless legs or face twitching
Amenorrhea (missed periods in women)
Gynecomastia (breast tissue growth in men)
Elevated blood sugar or cholesterol levels
Increased infections due to low white blood cell count

Serious Side Effects — Seek Immediate Help:

Severe chest pain or palpitations
Seizures or convulsions
High fever with extreme muscle stiffness (possible NMS — see below)
Swelling or redness in the legs (possible blood clot)
Severe skin rash, swelling of face or throat (allergic reaction)
Suicidal thoughts or sudden mood changes

Neuroleptic Malignant Syndrome (NMS)

Neuroleptic Malignant Syndrome (NMS) is a rare but life-threatening reaction linked to antipsychotic medicines like Amis 100 MG. It must be treated as a medical emergency.

Recognize the warning signs:

Very high body temperature (hyperthermia)
Severe muscle rigidity throughout the body
Confusion or loss of consciousness
Rapid or irregular heartbeat
Profuse sweating
Unstable blood pressure

If these symptoms appear, stop the medicine immediately and go to the emergency room. Early treatment is critical. Amis 100 MG should not be restarted after an NMS episode without thorough medical evaluation.

QT Prolongation & Heart Rhythm Warning

Amis 100 MG may cause QT prolongation a change in the heart’s electrical activity that can, in rare cases, trigger a dangerous irregular heartbeat called Torsades de Pointes.

You are at higher risk if you:

Already have a heart rhythm disorder
Have low potassium or magnesium levels (electrolyte imbalance)
Take other medicines that also prolong the QT interval
Have a personal or family history of heart problems

Important precautions:

Tell your doctor about any existing heart conditions before starting treatment
Your doctor may order an ECG before and during treatment
Never combine Amis 100 MG with other QT-prolonging medicines without medical advice
Report symptoms like palpitations, fainting, or sudden dizziness immediately

Contraindications Who Should NOT Take Amis 100 MG?

Do not take this medicine if you have:

Allergy to Amisulpride or any ingredient in the tablet
Pheochromocytoma (adrenal gland tumor)
Prolactin-dependent tumors, including prolactinoma
Prolactin-sensitive breast cancer
Parkinson’s disease
If you are currently taking Levodopa
Children under 15 years of age

Drug Interactions

Always inform your doctor about all medicines you are currently taking. Amis 100 MG should be used with caution or avoided with:

Levodopa – Directly opposes the effects of Amis; both medicines lose effectiveness
Antiarrhythmics – Severe risk of QT prolongation and dangerous heart rhythm changes
Lithium – Increased risk of NMS and nerve toxicity
Other antipsychotics – Additive side effects, including sedation and movement disorders
Antihypertensives – Risk of a severe drop in blood pressure
Antimalarials (e.g., mefloquine, chloroquine) – Increased risk of QT prolongation
Alcohol – Amplifies sedation and central nervous system depression

Pregnancy & Breastfeeding

Pregnancy: Amis 100 MG is not recommended during pregnancy. Babies born to mothers who took it during the third trimester may experience muscle stiffness, drowsiness, or feeding difficulties. Only use if your doctor determines the benefit clearly outweighs the risk.

Breastfeeding: This medicine passes into breast milk and may harm the baby. Breastfeeding should generally be discontinued if treatment with Amis 100 MG is necessary. Consult your doctor before making any decision.

Alcohol & Driving

Alcohol: Avoid alcohol completely during treatment. Combining alcohol with Amis 100 MG significantly increases drowsiness and risk of accidents.

Driving: This medicine causes dizziness, drowsiness, and blurred vision. Do not drive or operate heavy machinery until you know how this medicine affects you personally.

Storage Instructions

Store below 30°C in a cool, dry place
Keep away from direct sunlight and moisture
Store out of reach of children
Do not use after the expiry date printed on the pack
Do not store in the bathroom or near the kitchen sink

Substitutes for Amis 100 MG Tablet

The following medicines contain the same active ingredient (Amisulpride 100 MG) and may be used as substitutes under medical advice:

Substitute	Manufacturer
Amazeo 100 MG Tablet	Torrent Pharmaceuticals
Amigold 100 MG Tablet	Lupin Ltd
Zonapride 100 MG Tablet	Mankind Pharmaceuticals
Joykem O 100 MG Tablet	Alkem Laboratories

Always consult your doctor before switching to any substitute.

Final Thoughts

Amis 100 MG Tablet is a clinically proven antipsychotic that can make a meaningful difference in the lives of people living with schizophrenia and acute psychosis but it works best when used responsibly. Always take it exactly as prescribed, never stop it abruptly, and stay in regular contact with your psychiatrist throughout treatment. Being informed about serious risks like NMS and QT prolongation, monitoring your health through regular checkups, and making small lifestyle changes alongside medication can all contribute to a safer and more effective treatment journey.

Disclaimer: This article is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional before starting, changing, or stopping any medication.