Calfina Plus

Description

Calfina Plus Tablets combine tramadol, a non-selective opioid receptor agonist with affinity for mu receptors that also inhibits noradrenaline reuptake and enhances serotonin release, contributing to its analgesic and antitussive effects, with paracetamol, which provides central pain relief possibly through serotonergic pathway activation, prostaglandin synthesis inhibition, or cannabinoid receptor influence via metabolites. This combination addresses pain through multiple mechanisms.

Ingredients

• Tramadol HCl 37.5 mg.
• Paracetamol 325 mg.

Dosage Form

• Tablet.

Pack Details

• Pack Size: 1 box containing 1 strip (1 strip = 10 tablets).
• Prescription: Required.

Uses

Calfina Plus Tablets are indicated for:

• Management of moderate to severe pain.
• Pain and inflammation-related conditions.

Dosage

Dosage should always be determined by a doctor’s advice; the following information is provided as supportive reference for informational purposes only. Specific dosing for the tramadol HCl and paracetamol combination is based on pain severity and patient response.

In Case of Overdose

Overdose may lead to serious effects such as respiratory depression, seizures, or liver damage from paracetamol. Seek immediate medical attention.

Missed Dose

If a dose is missed, take it as soon as remembered. However, if it is nearly time for the next dose, skip the missed one and do not double the dose.

How to Use

Administer orally as tablets. Follow the healthcare provider’s instructions precisely, and do not exceed recommended usage to minimize risks like addiction.

When Not to Use

Avoid use in cases of:

• Allergy to tramadol, paracetamol, or any components.
• Acute alcohol intoxication.
• Concurrent use of sleeping aids, other pain relievers, or mood-altering medications.
• Treatment with monoamine oxidase inhibitors (MAOIs) or within 14 days of stopping them (used for depression or Parkinson’s).

Side Effects

Very Common Side Effects (may affect more than 1 in 10 people)

• Nausea.
• Dizziness.
• Drowsiness.

Common Side Effects (may affect up to 1 in 10 people)

• Vomiting.
• Digestive issues (constipation, flatulence, diarrhea).
• Stomach pain.
• Dry mouth.
• Itching.
• Sweating.
• Headache.
• Shaking.
• Confusion.
• Sleep disorders.
• Mood changes (anxiety, nervousness, euphoria).

Uncommon Side Effects (may affect up to 1 in 100 people)

• Elevated pulse or blood pressure.
• Heart rate or rhythm disturbances.
• Tingling, numbness, or pins and needles in limbs.
• Ringing in the ears.
• Involuntary muscle twitching.
• Depression.
• Nightmares.
• Hallucinations.
• Memory lapses.
• Difficulty breathing.
• Difficulty swallowing.
• Blood in stools.

Precautions & Warnings

• Opioids like tramadol should only be used by the prescribed individual; sharing increases addiction, overdose, or death risks.
• Discuss with a healthcare provider before use if you have epilepsy, history of seizures, recent head injury, shock, or severe headaches with vomiting.
• Regular or prolonged use may lead to addiction; follow prescriber’s guidance on duration and safe discontinuation.
• Consult a professional if you have liver issues or jaundice symptoms.
• Pregnancy Category: Always seek medical advice before use.

Drug Interactions

• Carbamazepine.
• Buprenorphine, nalbuphine, or pentazocine (opioid analgesics).
• Triptans.
• SSRIs.
• Morphine.
• Codeine (including as cough suppressant).
• Baclofen.
• Benzodiazepines or similar drugs.
• Certain antidepressants.
• Warfarin or phenprocoumon (anticoagulants).
• Metoclopramide, domperidone, ondansetron.
• Cholestyramine.

Food Interactions

No specific food interactions noted, but avoid alcohol to prevent enhanced side effects.

Storage/Disposal

Store at room temperature, protected from direct light and heat. Dispose of unused or expired medication properly, following local regulations.

Doctor’s Review

Dr. Imran Khan (Pain Management Specialist): “Calfina Plus Tablets serve as a pain relief option combining tramadol for opioid-mediated analgesia and serotonin/noradrenaline effects with paracetamol for central pain modulation, aiding in the management of moderate to severe pain through complementary mechanisms.”

Disclaimer

This product profile is provided for informational and educational purposes only. It does not constitute medical advice, diagnosis, or treatment recommendations. Always consult a qualified healthcare professional before starting, stopping, or changing any medication regimen. The information herein should not be used as a substitute for professional medical guidance.