Clamentin BD

Description

Co-Amoxiclav 1000mg Tablet is a combination antibiotic containing Amoxicillin and Clavulanic Acid, designed to fight a wide range of bacterial infections. Amoxicillin works by inhibiting bacterial cell wall synthesis, which causes bacteria to die. However, some bacteria produce beta-lactamase enzymes, which make them resistant to antibiotics like Amoxicillin. Clavulanic Acid, a beta-lactamase inhibitor, protects Amoxicillin from being broken down, ensuring the medicine remains effective even against resistant bacterial strains. This dual-action formula provides a strong and reliable defense against both Gram-positive and Gram-negative bacteria, making it useful for infections of the lungs, sinuses, urinary tract, skin, and soft tissues.

Key Benefits

• Broad-spectrum antibiotic effective against resistant bacterial infections.

• Combines two powerful agents for enhanced antibacterial action.

• Treats pneumonia, sinusitis, bronchitis, urinary tract infections, and skin infections.

• Helps prevent treatment failure in beta-lactamase-producing bacteria.

• Provides faster recovery from infection-related symptoms.

How It Works

• Amoxicillin blocks bacterial cell wall synthesis, leading to bacterial destruction.

• Clavulanic Acid inhibits the beta-lactamase enzyme, preventing bacterial resistance.
  Together, they form a synergistic combination that kills bacteria more effectively than either drug alone.

Uses

Co-Amoxiclav 1000mg Tablet is used for:

• Respiratory tract infections (pneumonia, bronchitis, sinusitis).

• Skin and soft tissue infections.

• Urinary tract infections (UTIs).

• Ear, nose, and throat infections.

• Infections caused by beta-lactamase-producing bacteria.

Dosage & Administration

• Usually taken every 8–12 hours, as prescribed by your doctor.

• Swallow the tablet whole with a full glass of water.

• Can be taken with or without food, but taking it with food reduces stomach upset.

• Complete the full course even if symptoms improve early.

In Case of Overdose

Symptoms may include nausea, vomiting, diarrhea, or abdominal pain.
Seek immediate medical attention if an overdose occurs. Do not self-medicate or take double doses.

Missed Dose

If you miss a dose, take it as soon as you remember.
If it’s almost time for your next dose, skip the missed one—do not double up.
To prevent missing doses, maintain a consistent schedule and set reminders.

When Not to Use

Avoid using Co-Amoxiclav if you have:

• Allergy to amoxicillin, clavulanic acid, or other penicillins.

• Liver dysfunction or jaundice related to previous antibiotic use.

• Severe kidney disease (without dose adjustment by your doctor).

• Mononucleosis (glandular fever) — may increase rash risk.

• History of severe allergic or skin reactions (Stevens-Johnson syndrome, TEN).

Side Effects

Common:

• Diarrhea

• Nausea, vomiting

• Mild rash or itching

• Headache or dizziness

Rare (serious):

• Allergic reaction (swelling of face/tongue, difficulty breathing)

• Persistent diarrhea (possible colitis)

• Liver enzyme elevation or jaundice

Seek medical help immediately for severe or persistent side effects.

Warnings & Precautions

• Complete the full course to avoid antibiotic resistance.

• Avoid alcohol during treatment to prevent stomach irritation.

• Inform your doctor if you have kidney or liver issues—dose adjustment may be needed.

• May reduce contraceptive pill effectiveness; use backup contraception.

• Elderly patients may be more prone to side effects—monitor closely.

Drug Interactions

Co-Amoxiclav may interact with:

• Probenecid – increases antibiotic levels in blood.

• Allopurinol – raises risk of skin rash.

• Warfarin and other anticoagulants – may increase bleeding risk.

• Methotrexate – increased toxicity risk.

• Oral contraceptives – may lower effectiveness.

• Mycophenolate mofetil – reduced absorption and efficacy.

Food Interactions

• Avoid alcohol – may worsen nausea or stomach upset.

• Avoid grapefruit juice – may alter drug metabolism.

• Dairy and calcium-rich foods – can reduce absorption (take 2 hours apart).

• High-fat meals – may delay absorption slightly.

• Limit caffeine – may increase jitteriness or restlessness.

Storage

• Store at room temperature (below 25°C) in a dry place.

• Keep away from moisture, heat, and direct sunlight.

• Do not store in bathrooms or kitchens.

• Keep out of reach of children.

• Dispose of expired or unused medicine safely; do not flush.

Quick Tips

• Take with a full glass of water; avoid crushing or chewing.

• Use the same dosing time daily for best results.

• Do not stop early—even if you feel better.

• Avoid taking antacids or iron supplements immediately before or after.

• Consult your doctor if diarrhea persists longer than 2 days.

Disclaimer:
This information is for educational purposes only and not a substitute for medical advice. Always use Co-Amoxiclav 1000mg Tablet under the supervision of a qualified healthcare professional.