Corace

Description: Corace Tablets 10mg contain Lisinopril, an angiotensin-converting enzyme (ACE) inhibitor used to manage hypertension and related cardiovascular conditions. It works by inhibiting ACE, which prevents the conversion of angiotensin I to angiotensin II, a vasoconstrictor that raises blood pressure. This leads to vasodilation, reduced aldosterone secretion, and lower blood pressure, even in low-renin hypertension. As a once-daily oral tablet, it’s suitable for adults requiring blood pressure control, often alongside lifestyle modifications like diet and exercise.

Ingredients: Lisinopril (as Lisinopril Dihydrate) 10mg.

Drug Class: Angiotensin-Converting Enzyme (ACE) Inhibitor / Antihypertensive.

Dosage Form: Tablet (1 strip = 10 tablets).

Uses: Corace Tablets are prescribed for:

• Treatment of hypertension (high blood pressure).
• Management of symptomatic heart failure.
• Short-term (6 weeks) therapy for hemodynamically stable patients post-acute myocardial infarction (within 24 hours).
• Renal complications in hypertensive patients with type 2 diabetes and incipient nephropathy.
• Reducing cardiovascular risks like stroke or kidney damage.

Doctor’s Review Cardiologists and general physicians frequently prescribe Corace for its reliable BP-lowering effects and heart protection. As one expert notes: “Corace 10mg is an effective starting dose for hypertension, blocking the renin-angiotensin system to ease heart workload. It shines in diabetic kidney protection, but watch for cough or potassium shifts in long-term users.”

Dosage (Follow physician’s instructions — typical guideline)

• Adults (Hypertension): Start with 10mg once daily; may increase to 20-40mg daily based on response (max 80mg).
• Heart failure: Initial 2.5-5mg daily; titrate to 20-40mg.
• Post-myocardial infarction: 5mg within 24 hours, then 10mg daily (max 40mg).
• Renal complications in diabetes: 5-10mg daily; adjust for kidney function.
• Take once daily, with or without food; use lowest effective dose.

In Case of Overdose Overdose may cause severe hypotension, tachycardia, or renal failure. Seek emergency care immediately. Symptoms include dizziness, fainting, or confusion. Treatment involves supportive measures (e.g., IV fluids, vasopressors); hemodialysis can remove Lisinopril if needed.

Missed Dose Take as soon as remembered unless close to the next dose. Do not double up to avoid excessive BP drop. Resume your schedule and consult your doctor if misses are common.

How to Use

• Swallow tablet whole with water, at the same time daily for steady effects.
• Can take with or without food; morning dosing helps monitor for dizziness.
• Monitor BP regularly; rise slowly to prevent orthostatic hypotension.
• Combine with a low-sodium diet and exercise as advised.
• Do not stop abruptly—taper under guidance to avoid rebound hypertension.

When Not to Use Avoid Corace if:

• Hypersensitive to Lisinopril, other ACE inhibitors, or excipients.
• History of angioedema from prior ACE therapy.
• Hereditary or idiopathic angioedema.
• Pregnant (especially second/third trimesters—fetal harm).
• Severe renal artery stenosis or bilateral renal artery issues.

Side Effects Common:

• Dizziness, headache, dry cough.
• Diarrhea, nausea, vomiting.
• Orthostatic hypotension, fatigue.

Uncommon / Severe (Stop and seek medical help):

• Angioedema (swelling of face, lips, tongue, throat).
• Myocardial infarction or stroke (from excessive hypotension).
• Hyperkalemia, renal failure, liver enzyme elevation.
• Rash, pruritus, mood changes, impotence.

Precautions & Warnings

• Discontinue immediately if angioedema occurs; provide antihistamines/corticosteroids and monitor until resolved.
• Risk of symptomatic hypotension in diuretic users, salt-restricted diets, or dehydrated patients—monitor closely at start.
• Use cautiously in left ventricular outflow obstruction or during surgery/anesthesia (may block compensatory renin release).
• Elderly or renal-impaired: Start low and titrate slowly; check kidney function regularly.
• May mask hypoglycemia in diabetics—monitor blood sugar.

Drug Interactions

• Diuretics, potassium supplements, or potassium-sparing diuretics (e.g., spironolactone): Risk of hyperkalemia.
• Lithium: Increased levels and toxicity.
• NSAIDs or ACE inhibitors: Worsen renal function.
• Nitrates (e.g., glyceryl trinitrate): Enhanced hypotension.
• Tricyclic antidepressants/antipsychotics: Increased hypotensive effects.
• Sympathomimetics: Reduced efficacy.
• Antidiabetics (insulins, oral agents): May enhance hypoglycemia.

Food Interactions

• Avoid excessive salt to maximize BP control.
• Limit potassium-rich foods (e.g., bananas, oranges) if on supplements.
• Grapefruit juice may raise Lisinopril levels—avoid.
• Maintain consistent diet; sudden changes can affect BP.
• Limit alcohol to prevent amplified dizziness.

Storage/Disposal

• Store at room temperature (15-30°C), away from direct light and heat.
• Keep in original strip, out of reach of children.
• Dispose via pharmacy returns; do not flush or trash expired tablets.

Quick Tips

• Check BP daily when starting; report dizziness or swelling promptly.
• Stay hydrated but avoid high-potassium intake without advice.
• Use a pill organizer for once-daily dosing.
• Inform surgeons of use before procedures.
• Carry a medical ID for allergies or angioedema risk.

Disclaimer This information is provided for educational purposes only and does not replace medical advice. Use only under the supervision of a licensed physician. Do not self-medicate.