Daploz

Description

Dapagliflozin is an oral antidiabetic medicine used in the management of type 2 diabetes. It lowers blood sugar by blocking glucose reabsorption in the kidneys, leading to glucose excretion in urine. Additionally, it supports insulin regulation by influencing hormones like GLP-1. This dual action helps improve blood sugar control, kidney protection, and cardiovascular outcomes.

Ingredients

• Dapagliflozin

Uses

• Control of blood sugar levels in adults with type 2 diabetes

• Reduces risk of kidney failure in diabetes patients

• Lowers risk of stroke, heart attack, and cardiovascular death

• Supports management of chronic kidney disease (CKD) with diabetes

• Not recommended for type 1 diabetes

Dosage

• Usual dose: 5 mg once daily

• May increase to 10 mg daily if blood sugar is not controlled

• Dose tailored based on kidney function, comorbidities, and physician advice

Overdose

• May cause nausea, vomiting, dizziness, dehydration, or fainting

• Seek emergency medical care immediately

Missed Dose

• Take as soon as remembered unless close to next dose

• Do not double dose

How To Use

• Take orally once daily, at the same time each day

• Swallow whole with water, with or without food

• Maintain regular blood sugar monitoring and healthy lifestyle (diet + exercise)

When Not to Use

• Severe kidney disease or dialysis patients

• Allergy to dapagliflozin or formulation ingredients

• Pregnancy & breastfeeding (unless prescribed by doctor)

• Severe dehydration or recurrent urinary infections

Side Effects

Common side effects:

• Increased urination, thirst, dry mouth

• Headache, dizziness, fatigue

• Nausea, vomiting, abdominal discomfort

• Urinary or genital infections

• Joint or muscle pain

Serious (rare):

• Diabetic ketoacidosis (nausea, vomiting, confusion, abdominal pain)

• Fournier’s gangrene (serious genital infection)

• Severe kidney impairment

Precautions & Warnings

• Monitor kidney and liver function regularly

• Caution in patients with heart disease, dehydration, or frequent UTIs

• Not recommended in children <18 years or elderly >65 years without specialist advice

• Stop immediately if ketoacidosis or severe infection develops

Drug Interactions

• Diuretics → increased risk of dehydration

• Insulin / oral antidiabetics → may cause hypoglycemia

• ACE inhibitors / ARBs / NSAIDs → may affect kidney function

• Alcohol → increases risk of ketoacidosis

Storage / Disposal

• Store at room temperature, away from moisture, heat, and direct light

• Keep out of reach of children

• Do not flush; follow safe medicine disposal guidelines

Laboratory Screening

• Blood sugar tests (FBS, HbA1c) for diabetes control

• Kidney function tests (eGFR, creatinine)

• Electrolytes, especially potassium

• Weight and blood pressure monitoring

Doctor’s Review

Dr. Ayesha Rahman, Consultant Endocrinologist:
“Dapagliflozin is a modern option for type 2 diabetes management. It not only helps lower blood sugar but also offers kidney and heart protection. Regular monitoring and medical supervision are essential to ensure safe and effective use.”

Disclaimer

This information is for educational purposes only and not a substitute for professional medical advice. Always consult your doctor before starting or adjusting any medication.