Domel

Description Domel Tablets 10mg contain Domperidone Maleate, a peripheral dopamine antagonist used to relieve nausea and vomiting. It works through a mix of enhancing stomach motility (gastrokinetic effects) and blocking dopamine receptors in the chemoreceptor trigger zone outside the blood-brain barrier, which helps control the urge to vomit without much central sedation. This oral tablet is prescribed for gastrointestinal disorders in adults and adolescents over 12 years, providing quick relief from upset stomach symptoms.

Ingredients Domperidone Maleate 10mg.

Drug Class Dopamine D2-Receptor Antagonist / Prokinetic / Antiemetic.

Dosage Form Tablet (1 box = 5 strips; 1 strip = 10 tablets).

Uses Domel Tablets are prescribed for:

• Treatment of nausea and vomiting from various causes (e.g., medications, infections).
• Relief from gastroparesis or delayed gastric emptying.
• Symptoms of reflux esophagitis or dyspepsia.
• Adjunct in functional dyspepsia or indigestion.
• Prevention of nausea post-chemotherapy or in migraine.

Doctor’s Review Gastroenterologists and general practitioners often choose Domel for its targeted antiemetic action. As one gastroenterologist remarks: “Domel is a reliable option for everyday nausea without the drowsiness of stronger alternatives. It speeds up stomach emptying effectively, but cardiac screening is crucial, especially in older patients or those with heart risks.”

Dosage (Follow physician’s instructions — typical guideline)

• Adults & Adolescents over 12 years: 10mg three to four times daily, 15-30 minutes before meals.
• Maximum: 40mg daily; reduce in hepatic impairment.
• Children: Only if prescribed, based on weight (0.25-0.5mg/kg).
• Use for short-term (up to 7 days); do not exceed without review.

In Case of Overdose Overdose may lead to drowsiness, confusion, extrapyramidal symptoms (e.g., tremors), or cardiac arrhythmias. Seek immediate medical attention. Treatment is supportive, including activated charcoal if recent, monitoring ECG for QT prolongation, and antiarrhythmic meds if needed. No specific antidote exists.

Missed Dose Take as soon as remembered unless near the next dose. Do not double up to avoid side effects like headache or irregular heartbeat. Resume your schedule and mention patterns to your doctor.

How to Use

• Swallow tablet whole with water, preferably before meals.
• Can take with or without food, but timing before eating maximizes gastrokinetic benefits.
• Stay upright after taking to aid digestion.
• Avoid chewing or crushing.
• Drink plenty of fluids to stay hydrated.

When Not to Use Avoid Domel if:

• Moderate to severe liver impairment.
• Known QTc prolongation or significant electrolyte imbalances.
• Underlying heart conditions like congestive heart failure.
• Hypersensitivity to domperidone or related drugs.
• Gastrointestinal hemorrhage or obstruction.

Side Effects Common:

• Headache (5.6%), diarrhea (5.2%).
• Somnolence (2.5%), rash (2.8%), pruritus (1.7%).
• Breast tenderness (4.4%), galactorrhea (3.3%).

Uncommon / Severe (Stop and seek medical help):

• Depression (2.5%), anxiety (1.6%), akathisia (1%).
• Amenorrhea (2.9%), irregular menstruation (2.0%), breast enlargement (5.3%).
• Signs of cardiac arrhythmia (palpitations, syncope).

Precautions & Warnings

• Studies link domperidone to higher risk of serious ventricular arrhythmias or sudden cardiac death—monitor ECG if at risk.
• Elderly over 60: Consult doctor due to increased cardiac sensitivity.
• Stop if arrhythmia symptoms appear (e.g., dizziness, chest pain) and seek prompt care.
• Use cautiously with electrolyte disturbances or on QT-prolonging meds.
• Not for long-term use without oversight.

Drug Interactions

• CYP3A4 inhibitors (e.g., indinavir, ketoconazole): Increase domperidone levels, raising cardiac risks.
• Antiarrhythmics (e.g., quinidine, amiodarone, sotalol): Prolong QT interval.
• Antipsychotics (e.g., haloperidol), antidepressants (e.g., citalopram), antibiotics (e.g., moxifloxacin): Heighten arrhythmia potential.
• Antifungals, antimalarials, or cancer drugs (e.g., toremifene): Avoid combinations.

Food Interactions

• Take before meals for best effect; high-fat meals may delay absorption slightly.
• Avoid grapefruit juice—it inhibits CYP3A4, boosting drug levels and risks.
• No major alcohol interactions, but limit to prevent worsening nausea.

Storage/Disposal

• Store at room temperature (15-30°C), away from direct light and heat.
• Keep in original packaging, out of reach of children.
• Dispose via pharmacy returns; do not flush.

Quick Tips

• Track symptoms in a journal to assess effectiveness.
• Eat small, frequent meals to ease nausea alongside the tablet.
• Avoid lying down right after taking.
• Get baseline ECG if you have heart history.
• Stay hydrated, especially if diarrhea occurs.

Disclaimer This information is provided for educational purposes only and does not replace medical advice. Use only under the supervision of a licensed physician. Do not self-medicate.