Etoposide

Etoposide

Etoposide is a topoisomerase II inhibitor that stops DNA repair and replication in rapidly dividing cells, helping to control cancer growth. It is commonly used for small-cell lung cancer, testicular cancer, and lymphomas, given either orally or through IV infusion as part of chemotherapy.

Key Benefits

• Effective in lung, testicular, and blood cancers

• Available in oral or IV form

• Often combined with cisplatin or carboplatin

• Safe and monitorable treatment option

Doctor Review

Dr. Sara Rehman, MBBS, FCPS (Oncology): “Etoposide remains a core drug in lung and germ cell cancer treatment. Dosing depends on kidney function and blood counts. When paired with platinum-based agents, outcomes improve significantly. Regular monitoring helps manage side effects effectively.”

Side Effects

Common: Nausea, fatigue, temporary hair loss, mouth soreness.
Serious: Low blood counts, infections, allergic reactions.
Call your doctor immediately if you have: Fever, bleeding, rash, or breathing problems.

Warnings

• Pregnancy: Contraindicated (Category D).

• Bone marrow suppression: Nadir at 7–14 days.

• Kidney/Liver issues: Dose adjustment may be needed.

• Handling: Avoid contact if pregnant.

Administration

IV infusion (30–60 min) or oral capsules every 21 days, usually combined with platinum drugs. Administered only under oncology supervision.

Monitoring

Weekly CBC, kidney and liver tests. Next cycle delayed if ANC <1500 or platelets <100K.

CureCart Oncology Support

Comprehensive support for chemotherapy coordination, patient guidance, and safety monitoring.

Disclaimer: For general awareness only — not a medical prescription. Use Etoposide only under the supervision of a qualified oncologist.