Gluconorm

Description Glimepiride 1mg is a second-generation sulfonylurea used as a second-line treatment for type 2 diabetes before insulin therapy. It stimulates insulin release from pancreatic beta cells by binding to and blocking ATP-sensitive potassium channels, causing membrane depolarization and calcium influx, which triggers insulin secretion into the bloodstream. This helps lower blood sugar levels and manage diabetes effectively. Formulated as a tablet, it’s suitable for adults seeking glycemic control alongside diet and exercise.

Ingredients Glimepiride 1mg.

Drug Class Sulfonylurea / Antidiabetic.

Dosage Form Tablet (available in blister packs, typically 10 or 30 tablets per pack).

Uses Glimepiride is prescribed for:

• Managing blood sugar levels in type 2 diabetes.
• Enhancing insulin secretion from the pancreas.
• Reducing the risk of diabetes-related complications (e.g., neuropathy, retinopathy).
• Use in combination with other antidiabetic medications (e.g., metformin).
• Improving overall glycemic control.

Doctor’s Review Endocrinologists and primary care physicians often recommend Glimepiride for its efficacy in type 2 diabetes management. As one specialist notes: “Glimepiride is a trusted option for patients needing better blood sugar control. Its once-daily dosing and low risk of severe side effects make it a practical choice for many, especially when combined with lifestyle changes.”

Dosage (Follow physician’s instructions — typical guideline)

• Adults: Start with 1mg once daily, taken with breakfast or the first main meal.
• Based on blood sugar response, the dose may be adjusted to 0.5mg (lower) or 2mg (higher) once daily.
• Maximum dose: 8mg daily (rarely used).
• Do not adjust dosage without consulting your doctor.

In Case of Overdose Overdose is a medical emergency and may cause severe hypoglycemia, confusion, rapid heartbeat, or loss of consciousness. Seek immediate medical attention or contact a Poison Control Center. While awaiting help, monitor vital signs (e.g., heart rate, blood pressure). If hypoglycemia is suspected, consume fast-acting carbohydrates (e.g., glucose tablets, juice). In clinical settings, treatments may include activated charcoal (if recent ingestion), IV glucose, or insulin under supervision. Monitor liver function and electrolytes, as prolonged overdose can affect these systems.

Missed Dose Take the missed dose as soon as remembered unless it’s close to the next scheduled dose. Do not double dose, as this risks hypoglycemia. If unsure, consult your doctor or pharmacist to avoid side effects like dizziness, sweating, or blurred vision.

How to Use

• Take once daily with breakfast or the first main meal to maintain consistent blood levels.
• Swallow the tablet whole with water; do not crush or chew.
• Follow your doctor’s diet and exercise plan to optimize blood sugar control.
• Monitor for hypoglycemia symptoms (e.g., sweating, shakiness, hunger) and keep fast-acting sugars handy.
• Check blood sugar regularly using a glucometer as advised.
• Consult your doctor if weight gain or other concerns arise.

When Not to Use Avoid Glimepiride if:

• Allergic to Glimepiride, sulfonylureas, or any excipient (e.g., lactose).
• Experiencing severe hypoglycemia or low blood glucose.
• Diagnosed with severe liver or kidney disease.
• Pregnant, planning pregnancy, or breastfeeding.
• Diagnosed with type 1 diabetes or diabetic ketoacidosis.
• Undergoing surgery or have a history of alcohol/drug abuse.
• Allergic to peanuts/almonds (trace amounts in some formulations).
• Have metabolic acidosis or severe heart/vascular conditions.

Side Effects Common:

• Hypoglycemia (low blood sugar: sweating, shakiness, hunger).
• Weight gain.
• Nausea, headache, dizziness.
• Gastrointestinal upset (e.g., stomach pain, diarrhea).

Uncommon / Severe (Stop and seek medical help):

• Severe hypoglycemia (confusion, seizures, loss of consciousness).
• Allergic reactions (rash, itching, swelling).
• Abnormal liver function tests.
• Blood disorders (e.g., low platelet count, anemia).

Precautions & Warnings

• Monitor blood sugar regularly to avoid hypoglycemia, especially during dose adjustments.
• Use cautiously in liver, kidney, or heart conditions.
• Avoid alcohol, as it can increase hypoglycemia risk.
• Contains lactose — check with doctor if intolerant.
• May cause weight gain — discuss lifestyle adjustments with your doctor.
• Not suitable for type 1 diabetes or ketoacidosis.

Drug Interactions

• Enhance hypoglycemia: Beta-blockers, ACE inhibitors, NSAIDs, or other antidiabetics (e.g., insulin, metformin).
• Reduce efficacy: Diuretics, corticosteroids, thyroid medications.
• Alcohol: Increases risk of low blood sugar.
• CYP2C9 inhibitors/inducers (e.g., fluconazole, rifampicin): May alter Glimepiride levels.

Food Interactions

• Take with food (preferably breakfast) to reduce stomach upset.
• Avoid alcohol to prevent hypoglycemia risk.
• Maintain a consistent diet as prescribed to stabilize blood sugar.

Storage/Disposal

• Store at room temperature (15-25°C), away from heat, moisture, and direct sunlight.
• Keep in original blister pack to protect from light and air.
• Store out of reach of children and pets.
• Dispose of expired or unused tablets as per local medical waste guidelines (e.g., via pharmacy take-back programs).

Quick Tips

• Take with breakfast to align with your body’s insulin needs.
• Carry glucose tablets or juice for quick hypoglycemia relief.
• Follow a balanced diet and exercise plan to boost efficacy.
• Report weight gain or persistent low blood sugar to your doctor.
• Regular blood tests (e.g., HbA1c) help track progress.

Disclaimer This information is provided for educational purposes only and does not replace medical advice. Use only under the supervision of a licensed physician. Do not self-medicate.