Mesotec

Mesotec tablets combine diclofenac sodium, a non-steroidal anti-inflammatory drug (NSAID) that reduces pain and inflammation by blocking prostaglandin production, with misoprostol, a prostaglandin analog that protects the stomach lining from diclofenac’s potential to cause ulcers. This dual action makes it effective for relieving pain and inflammation in conditions like rheumatoid arthritis, osteoarthritis, or ankylosing spondylitis, while minimizing gastrointestinal risks. Taken orally, it offers balanced relief for joint and muscle pain with a focus on stomach safety.

Expert Review

Dr. Muhammad Asif, a respected Pakistani rheumatologist at Jinnah Hospital, Lahore, explains that the diclofenac in Mesotec targets inflammation and pain in arthritic conditions, while misoprostol helps shield the stomach from NSAID-related damage. He notes its effectiveness for chronic joint issues but advises monitoring for side effects like stomach upset or dizziness, especially in older patients or those with a history of ulcers.

Primary Uses

• Relieves pain and inflammation in rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis.
• Protects the stomach lining to reduce ulcer risk during NSAID use.

Indications

Used for managing pain and inflammation in chronic arthritic conditions while preventing NSAID-induced gastric or duodenal ulcers, particularly in high-risk patients.

Side Effects

Some may experience stomach upset, nausea, diarrhea, menorrhagia, intermenstrual bleeding, skin rash, itching, headache, dizziness, swelling, or elevated liver enzymes. Rarely, fetal malformation risks may apply. Contact your doctor if severe or persistent.

Warnings

• Pregnancy: Avoid, especially in the third trimester, due to fetal malformation risks. Consult your doctor.
• Lactation: Not recommended; diclofenac and misoprostol may pass into breast milk.
• Driving: Avoid if you feel dizzy or disoriented after taking.
• Alcohol: Limit or avoid alcohol to reduce stomach irritation and bleeding risks.

Precautions

• Use cautiously if you have a history of ulcers, gastrointestinal bleeding, or liver/kidney issues.
• Monitor for signs of stomach pain, bleeding, or liver function changes.
• Inform your doctor if you have heart conditions, asthma, or are planning pregnancy.
• Not recommended for children due to limited safety data.

Contraindications

Avoid if:

• Allergic to diclofenac, misoprostol, or other NSAIDs/prostaglandins.
• You have active peptic ulcers, severe heart failure, or severe liver/kidney impairment.
• Pregnant, especially in the third trimester, or planning pregnancy.

How to Use

Take 1 tablet (50 mg/0.2 mg) two to three times daily or as prescribed, with food to reduce stomach upset. Swallow whole with water; don’t crush or chew. Follow your doctor’s dosing instructions, typically not exceeding 150 mg diclofenac daily. Take at consistent times daily.

Storage

Store at room temperature (18-25°C), away from light, moisture, and children. Keep in the original packaging with a tight seal.

Quick Tips

• Take with meals to minimize stomach discomfort.
• Don’t exceed the prescribed dose to avoid stomach or liver issues.
• Report unusual bleeding, severe pain, or swelling to your doctor.
• Avoid if planning pregnancy due to fetal risks.

Disclaimer

This information is for general guidance only. Consult a doctor for personalized advice on side effects, precautions, or interactions, as individual needs vary.